Navigation Links
False negative tests in breast cancer may lead to wrong drug choice
Date:6/27/2011

A team of Yale Cancer Center researchers has confirmed that between 10-20% of breast cancers classified as Estrogen Receptor (ER) negative are really positive. Understanding when and why breast cancers may be misclassified has important implications for treatment and outcomes for women diagnosed with breast cancer. Its findings are published online in the June 28 Journal of Clinical Oncology.

A woman diagnosed with breast cancer can be tested by immunohistochemistry (IHC), a process that detects the presence of specific proteins in cancer tissue. Those who test positive for ER are prescribed an endocrine therapy, like Tamoxifen, Letrazol or a similar drug. The 10-20% of cancer patients who are incorrectly classified as ER negative may be treated with less effective therapies.

Led by David Rimm, M.D., professor of pathology at Yale School of Medicine, the research team highlighted the limitations of IHC in the assessment of Estrogen Receptor in breast cancer and defined a new method for standardizing ER measurement. It used a novel method to detect the estrogen receptor that uses fluorescent detection in conjunction with a series of standard controls. The team reported that this more sensitive and reproducible method finds cases initially called "negative" that behave as "positive."

"Our research shows that the conventional methods of measurement of Estrogen Receptor may result in a 10-20% false negative rate," said Rimm. "This may be leading to under-treatment of breast cancer patients and we may be missing the opportunity to use one of our best drugs (Tamoxifen) due to inadequate testing."

The assay has been licensed to HistoRx Inc. of Branford, Conn. The test will soon be available to patients in Clinical Laboratory Improvement Amendments-certified labs. The first lab to release the test will be Genoptix Inc. based in Carlsbad, California.


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Page: 1

Related medicine news :

1. Higher volume reduces false positives in screening mammography
2. Repeat MRI screening for breast cancer results in fewer false positives
3. Damage of False-Positive Mammograms Overlooked: Study
4. Women with false-positive mammograms report high anxiety and reduced quality of life
5. Many Heart Patients Place False Hope in Angioplasty
6. The cancer biomarker conundrum: Too many false discoveries
7. Many False-Positive HIV Test Results for Those in AIDS Vaccine Trials
8. Many Supplements Said to Contain Toxins, Make False Health Claims
9. False positives in TB diagnosis lead to real negatives for HIV patients
10. False Claims Act Attorney Tim Terry to Address Arizona Chapter of the Association of Certified Fraud Examiners
11. Chicago Hospital to Pay More Than $1.5 Million to Resolve Medicare False Claims Act Allegations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Viejo, CA (PRWEB) October 22, 2014 ... Jay Cormier, Sr. Vice President of Sales, will be ... the upcoming Meetings Technology Expo on October 28, at ... also be hosting a booth as well as a ... how Lintelus Meeting can create a more engaging event ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. ... and length may be showing a genetic propensity for obesity ... genes have been linked to increased body fat, but the ... lean muscle, the researchers said. At 1 year, kids ... 2 and 3, however, these genes were linked to excessive ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... may lead to increased blood pressure, according to a new ... in blood pressure for young adult women or for teenagers, ... drank lightly or moderately, their risk of high blood pressure ... parallels studies in older adult men and women," said lead ...
(Date:10/22/2014)... HealthDay Reporter , MONDAY, Oct. 20, 2014 ... guidelines for health workers treating Ebola patients, now requiring full ... respirator at all times. The U.S. Centers for Disease ... two Dallas nurses contracted Ebola while caring for the first ... Eric Duncan. Nina Pham is currently being treated for her ...
(Date:10/20/2014)... October 20, 2014 With a mere ... Charlie Crist made a brief fundraising stop at the ... Thursday. , Fresh from a debate last night with ... the stage for the first seven minutes because Crist ... governor described the incident in one word: "weird." , ...
Breaking Medicine News(10 mins):Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3
... (Amex: CPD ) announced today that the ... approval for the Company,s,Abbreviated New Drug Application (ANDA) ... and 20 mg., Escitalopram is indicated for ... is for the generic bioequivalent product,to Lexapro(R), which ...
... The National AIDS Fund (NAF) in,Washington, ... an expanding,network of Community Partnerships that support ... Boston marketing agency, HGX Creative,to spearhead its ... areas: National, Community Partnerships and Individual Consumer,Marketing., ...
... Davi Skin,Inc. (OTC Bulletin Board: DAVN) today announced ... September, October and November., Media placements for ... Vogue, Arena, Esquire, Bazaar and Wallpaper Magazine in ... Confidential and,Napa Sonoma Magazine in the United States. ...
... LOS ANGELES, Nov. 30 AIDS Healthcare,Foundation (AHF) will ... partnership-the City of Los Angeles HIV,Testing Initiative announced this ... include:, -- Staffing and covering the salary ... for the overall HIV testing initiative, -- Spearheading ...
... pregnancy makes little difference , , FRIDAY, Nov. 30 (HealthDay ... C doesn,t reduce the chances of the blood pressure ... the dangerous pregnancy complication, a new report finds. ... of this regimen in preventing preeclampsia, said study author ...
... Clinic Will Offer Assessments for Diabetic Retinopathy, a ... Leading Cause of ... Wake,Forest, NC company specializing in retinal risk assessment for diabetics,announced today ... solution to provide retinal imaging risk assessment., MacGregor Medical Center ...
Cached Medicine News:Health News:Caraco Pharmaceutical Laboratories, Ltd. Announces Tentative FDA Approval for Generic Lexapro(R) 2Health News:HGX Selected as Creative Agency for National AIDS Fund New Brand 2Health News:HGX Selected as Creative Agency for National AIDS Fund New Brand 3Health News:AIDS Healthcare Foundation's Role in the City of Los Angeles' HIV Testing Initiative 2Health News:Extra Doses of Vitamins C, E Don't Guard Against Preeclampsia 2Health News:Extra Doses of Vitamins C, E Don't Guard Against Preeclampsia 3Health News:Digital Healthcare Announces MacGregor Medical Center San Antonio to Utilize Retasure for Retinal Imaging Assessment 2
(Date:10/22/2014)... RPh, of Vernak Farms Pharmacy in Skaneateles, ... Roentsch Scholarship by the Professional Compounding Centers of America ... during PCCA,s International Seminar, held October 8-10, ... pharmacist and PCCA member who embodies the innovative and ... pharmacist in the compounding community. George ...
(Date:10/22/2014)... Calif. , Oct. 22, 2014  Paper ... products, has developed APLS ® Body Guard ... minimizes the spread of bacteria and virus while ... APLS Body Guard Bio features a rugged, external ... edges that create a leak-proof inner chamber that ...
(Date:10/22/2014)... 22, 2014  CryoLife, Inc. (NYSE: CRY ... focused on cardiac and vascular surgery, announced today that ... Executive Officer, has been elected to the Company,s Board ... Steven G. Anderson , Executive Chairman of CryoLife, stated, "Since ... be an excellent leader who is well positioned to ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3
... WARSAW, Ind., Jan. 11 Zimmer Holdings, Inc. (NYSE: ... 2009 sales and earnings conference call will be broadcast live over ... Time. A news release detailing the quarterly results will be ... , The live audio webcast can be accessed via Zimmer,s Investor ...
... , SAN DIEGO, Jan. 11 CareFusion (NYSE: ... today that the Food and Drug Administration (FDA) has given ... ® SE line of infusion pumps (also known as ... Clinical and Medical Products division of Cardinal Health, has been ...
Cached Medicine Technology:Zimmer Holdings Announces Live Audio Webcast and Conference Call of Fourth Quarter and Full-Year 2009 Results 2FDA Lifts Injunction on Manufacture and Sale of CareFusion Alaris(R) SE Pump 2
... Featuring an expanded database containing over ... identification cards, VITEK 2 Compact offers ... amount of time (2 to 14 ... of microorganisms that contaminate production areas ...
... transmitting data from multiple sources is ... Dawnings ResultNet/Plus software allows you to ... your communications network., ,ResultNet/Plus eliminates the ... from largescale or multi-site laboratories to ...
... Software is a powerful Java-based interface ... to control laboratory instrument connections and ... used in two applications: embedded in ... on a network PC station. Within ...
Powerful LED Illumination , The ultrabright and compact 3S LED HeadLight from HEINE for Powerful, coaxial illumination...
Medicine Products: