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False negative results found in prognostic testing for breast cancer
Date:6/18/2014

A recent study evaluating HER2 testing in a large cohort of women with breast cancer found important limitations in the conventional way HER2 testing is performed in the US and internationally.

Dartmouth-Hitchcock Norris Cotton Cancer Center physicians and researchers retested tumor samples from a large group of women and found that 22 out of 530 women had their tumor type incorrectly classified. They reported their findings in a publication titled "Assessing the Discordance Rate between Local and Central HER2 Testing in Women with Locally Determined HER2-Negative Breast Cancer," which was published in Cancer on June 13, 2014.

Breast cancer is categorized into several subtypes based on conventional laboratory, and newer molecular tests. This study looked at the accuracy in classifying breast cancers in one particular subtype, specifically those that are "human epidermal growth factor receptor 2" or HER2 positive. What is particularly important in accurately determining HER2 in breast cancer is that when a woman's cancer tests positive for HER2, there are specific treatments proven extremely effective in improving outcome and preventing recurrence of cancer. These HER2 directed, or targeted, therapies are critically important in treating women with HER2 positive breast cancer.

"We, and other groups, have previously shown that a certain percentage of cases found to be HER2 positive in local laboratories are in fact HER2 negative when tested in more experienced central labs. There has, however, been almost no research evaluating the accuracy of a negative HER2 result," said Peter A. Kaufman, MD. "This is the first large study to look at this. What is comforting is that we found that re-testing in experienced larger labs confirmed the original local lab results in the majority of cases."

Kaufman noted that they did find about four percent of cases that were originally determined to be HER2 negative were in fact HER2 pos
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Contact: Donna Dubuc
donna.M.Dubuc@Dartmouth.edu
603-653-3615
The Geisel School of Medicine at Dartmouth
Source:Eurekalert

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