Navigation Links
False-Positive Mammogram Results May Turn Out Not to Be: Study
Date:4/6/2012

By Kathleen Doheny
HealthDay Reporter

THURSDAY, April 5 (HealthDay News) -- Women who have a false-positive result on their mammogram may be at higher long-term risk of developing breast cancer than those whose initial test is negative, according to a new Danish study.

However, the link between false-positive results and an increased risk of breast cancer was weaker among women who had been screened from the early 2000s on, the researchers found.

Experts have long known that screening mammograms, done in healthy women to detect breast cancer early, are bound to lead to some false-positive test results. These are results that seem to detect cancer but turn out to be false upon further testing.

However, few studies have followed these women with false-positive results long-term to evaluate what happens, said My von Euler-Chelpin, an associate professor of epidemiology at the University of Copenhagen, who led the study. The new findings were published online April 5 in the Journal of the National Cancer Institute.

"Some earlier research has found similar results, but to my knowledge there has been no study with such a long follow-up as this one," Euler-Chelpin said.

For the study, the investigators evaluated 58,000 Danish women, aged 50 to 69. They looked at those with negative mammogram results and those that turned out to be -- with further testing such as ultrasound and biopsies -- false positives. They looked at both invasive breast cancer and the early cancer known as ductal carcinoma in situ.

The average follow-up time was nearly 11 years. Women who had received false-positive results in the mid-1990s had about a 1.5 to 1.6 times higher risk of eventually developing breast cancer compared to those who had negative initial mammograms. This increased risk persisted even at six or more years, the researchers found.

For the false-positive group that underwent their mammograms in the year 2000 or later, the link with the increased risk was not significant from a statistical point of view, the study authors noted. "The excess risk might still be there," von Euler-Chelpin said. It could be, she said, that there were not enough cases to detect accurately any increase in risk.

Why would the women with false-positive results be at higher risk? "The reason for this is not known, but misclassification is a possibility," von Euler-Chelpin said. That is, the women actually had breast cancer but the tests did not detect it.

Whether the findings would apply to U.S. women is not clear, said Dr. Stephanie Bernik, chair of surgical oncology at Lenox Hill Hospital in New York. She reviewed the findings but was not involved in the study.

The research seems to suggest that ''screening has gotten so much better [that] we are more accurate," Bernik said. "We are better at figuring out who needs a biopsy and who doesn't," she added.

"In the past, false positives [in the study] were clearly an indication of an increased risk of getting breast cancer," Bernik said of the study findings. "Now, it is less clear," she said of the more recent findings, since 2000.

The Danish researchers encourage women with false-positive tests to continue to get regular follow-up screenings as recommended by their doctors.

In the United States, Bernik said, a woman who has had a false-positive mammogram result is often, but not always, advised to get another mammogram in six months. It depends on what the doctors see on the mammogram and other information. Women should follow their doctors' advice on the follow-up schedule, she said, as every case is different.

Bernik finds that among her patients, women who have had a previous false-positive result -- and had further testing that ruled out cancer -- often say they are tempted to ignore recommendations to get further testing when they get a repeat mammogram result that calls for further testing. That is a mistake, she tells them.

"Women can't rely on the fact they had a false-positive test in the past to forgo additional studies going forward," Bernik said. "You have to treat each new finding as its own entity."

More information

To learn more about mammograms and false-positive results, visit the U.S. National Cancer Institute.

SOURCES: My von Euler-Chelpin, Ph.D., associate professor, epidemiology, University of Copenhagen, Denmark; Stephanie Bernik, M.D., chair, surgical oncology, Lenox Hill Hospital, New York City; April 5, 2012, Journal of the National Cancer Institute, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Many False-Positive HIV Test Results for Those in AIDS Vaccine Trials
2. Women with false-positive mammograms report high anxiety and reduced quality of life
3. Damage of False-Positive Mammograms Overlooked: Study
4. High rate of false-positives with annual mammogram
5. Less Frequent Mammograms May Lower False-Positive Results
6. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
7. Survey Finds Access to Mammograms Declining for Women Under Age 50
8. The American Association on Health and Disability (AAHD) and the Susan G. Komen for the Cure Partner to Increase Accessibility for Women with Disabilities at Mammogram Facilities in the DC Metro Area
9. Access to Mammograms Drops After Guidelines Change
10. Mammogram Plus MRI Seems Cost-Effective in High-Risk Women
11. Mammogram Plus MRI Cost-Effective in High-Risk Women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
False-Positive Mammogram Results May Turn Out Not to Be: Study
(Date:7/24/2017)... ... , ... “Journey to the Light: The Quest for Happiness and Love. . ... to finding herself. “Journey to the Light: The Quest for Happiness and Love. ... writer of newsletters, manuals, and articles, who has recently decided to expand her literary ...
(Date:7/23/2017)... (PRWEB) , ... July 23, 2017 , ... A ... in St. Louis, and led by the Minneapolis Veterans Administration Health Care System overwhelmingly ... of the disease offers very few benefits. , In the cases involved with ...
(Date:7/23/2017)... ... 23, 2017 , ... Technology is making it easier for ... tools are helping patients become more actively involved in their care and maintaining ... survey, released today by the American Hospital Association’s (AHA) Health Forum. , According ...
(Date:7/23/2017)... ... July 23, 2017 , ... Viora Ltd., a ... US Patent No. 9,038,640 by the United States Patent and Trademark Office. The ... combination of Switching, Vacuum, and Cooling mechanisms to further increase the efficacy and ...
(Date:7/21/2017)... ... July 21, 2017 , ... "As a doctor of lung medicine ... catheters available on the market," said an inventor from Center Valley, Pa. "My idea ... the patient." , He developed the patent-pending PLEURAL SAFE-t-STAT CATHETER KIT to offer an ...
Breaking Medicine News(10 mins):
(Date:7/11/2017)... 11, 2017  The global market for liquid biopsy ... $394.1 million in 2016.  Although in early stages, the ... in particular as a result of the gradual shift ... recent introduction of a significant number of new liquid ... of tumor biomarkers to guide treatment decisions. ...
(Date:7/10/2017)... , July 10, 2017 The Institute for ... methods, is the recipient of a VITROCELL® inhalation exposure ... International Science Consortium. The device, which is designed to ... expose human lung cells to airborne test materials in ... use the VITROCELL® system for testing combustible tobacco products, ...
(Date:7/5/2017)... 5, 2017 Wolfmet 3D  printed tungsten collimator manufactured by ... and manufacturing combine to progress molecular radiotherapy imaging. ... are unable to accurately quantify the radiation absorbed by those ... the success of this radiotherapy treatment has been available — ... ...
Breaking Medicine Technology: