Navigation Links
Fall babies: Born to wheeze?
Date:11/20/2008

It is said that timing is everything, and that certainly appears to be true for autumn infants. Children who are born four months before the height of cold and flu season have a greater risk of developing childhood asthma than children born at any other time of year, according to new research.

The study analyzed the birth and medical records of more than 95,000 children and their mothers in Tennessee to determine whether date of birth in relationship to the peak in winter respiratory viruses posed a higher risk for developing early childhood asthma. They found that while having clinically significant bronchiolitis at any age during infancy was associated with an increased risk of childhood asthma, for autumn babies, that risk was the greatest.

"Infant age at the winter virus peak following birth independently predicts asthma development, with the highest risk being for infants born approximately four months prior to the peak, which is represented by birth in the fall months in the Northern hemisphere. Birth during this time conferred a nearly 30 percent increase in odds of developing asthma," said Tina V. Hartert, M.D., M.P.H., associate professor of medicine and director of the center for Asthma Research at Vanderbilt University, and principal investigator of the study.

The research was published in the first issue for December of the American Journal of Respiratory and Critical Care Medicine, a publication of the American Thoracic Society.

The study demonstrated for the first time that timing of birth in relationship to the peak in winter virus activity independently predicts asthma development.

The researchers propose two non-mutually exclusive possible reasons for the link: One, that there is a genetic susceptibility common to both bronchiolitis and the development of asthma; and two, that an environmental exposure such as winter viral infection causes asthma.

"The risk of progressing from bronchiolitis to asthma is almost certainly influenced by genetic factors," wrote Dr. Hartert. "However, if this association were due only to genetic factors, there would be a seasonal effect on infection but not on asthmaInstead we have shown that there is variation in the risk of developing asthma by the timing of birth in relationship to the winter virus peak for each year studied. This supports a causal relationship of childhood asthma with the winter virus peak after birth."

Unfortunately, predicting the peak of winter virus season is difficultit can vary by up to ten weeks a year, and Dr. Hartert notes that avoiding winter virus infection would be nearly impossible70 percent of infants are infected in their first year of lifebut that for families whose infants are at high risk for developing asthma, there are a number of ways to reduce the risks associated with birth timing, including avoiding infection through administration of a vaccine or immunoprophylaxis or timing of birth in the spring months. These strategies hold the hope for asthma prevention, however, these interventions first need to be studied.

"Prospective trials with antiviral strategies, including potential new vaccines targeting [respiratory viruses] in selected populations at risk should give us better understanding of the role of viral infections in early life in the causation of childhood asthma," wrote Renato T. Stein, M.D., Ph.D., of the Pontifcia Universidade Catlica in Porto Alegre, Brazil in the accompanying editorial.

Currently no effective primary and secondary asthma prevention measures exits, noted Dr. Hastert. "The next critical step is support for studies designed to determine whether prevention of the ubiquitous infections during infancy prevents childhood asthma."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... Netc , a leading provider of barcode and ... Inc. The Dataware acquisition enables Netc to continue to grow its label business, customer base ... provides customers with the ability to print and label tape media on site and on ...
(Date:5/3/2016)... ... May 04, 2016 , ... ... That message is reaching the global health community through expanding activities that embrace ... of cancer in the resource-limited countries. , In support of this ...
(Date:5/3/2016)... ... May 03, 2016 , ... ProIntro Glitch is a set of ... Film Studios’ titles allow users to add a terrifying opener to any video or ... lines and accents. To add greater contrast, all the user has to do is ...
(Date:5/3/2016)... ... ... In April, Amerec launched a new website designed with optimal user experience in ... sauna solutions. , First, the Amerec website has been redesigned to be easier to ... features, especially the Steam Builder Tool , to both mobile and desktop devices. ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... Sue Desmond-Hellmann, ... Class of 2016 to stretch the limits of human possibility in her keynote address ... p.m. in the Georgia Dome. , Drawing on her rich experience as a scientist, ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK ... technology, today announced Food and Drug Administration (FDA) ... defibrillator that provides heart failure patients with access ... devices also have remote monitoring with daily automatic ... the heart rate in response to physiological demands. ...
(Date:5/3/2016)... May 3, 2016 Pharmaceutical giant ... million to a woman who says its talc-based powder ... Gloria Ristesund $5 million in compensatory damages ... (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , This ... the company. In February, the same court awarded $72 ...
(Date:5/3/2016)... 2016  Forté Elements, LLC (Forté) is excited to announce the launch of its ... nutritional needs of recovery for a variety of clinical conditions. Founded in 2013, Forté ... http://photos.prnewswire.com/prnh/20160502/362548 Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
Breaking Medicine Technology: