Navigation Links
Failing to bridge the gap between test tubes, animals, and human biology
Date:10/20/2011

Reasoning used in many highly cited cancer publications to support the relevance of animal and test tube experiments to human cancer is questionable, according to a study by researchers from Universit Libre de Bruxelles published in the open-access journal PLoS Computational Biology on October 20th 2011.

Most experimental biomedical research is performed on animals or on cells living in test tubes due to the limits ethics guidelines place on experimental investigation on humans. Bridging the gap between these experiments and human biology is a major hurdle. A connection is often made using the prognostic value of molecular markerssets of genes whose activation is related to particular biological processes. Researchers first determine a cancer marker and then assess the ability of the marker to predict survival. The fact that the marker is prognostic is considered to be evidence that the particular biological process is an important driver of cancer.

The authors question this reasoning by highlighting that most whimsical molecular markers, for example genes associated with mice social behavior, are prognostic in human breast cancer. Moreover, they studied 47 markers published in leading scientific journals, representing various biological processes supposedly relevant to breast cancer. They confirmed their prognostic value, but found that 60% of them are not better than random markers devoid of any biological rationale. Thus, the prognostic ability of molecular markers in human breast cancer seems to convey little meaningful information relevant to the biological processes of breast cancer progression.

The study recognizes that some molecular markers are truly prognostic and act as a useful guide to breast cancer treatment, even though they may fail to support the causal role of specific biological mechanisms in human breast cancer progression.


'/>"/>
Contact: Vincent Detours
vdetours@ulb.ac.be
32-255-54220
Public Library of Science
Source:Eurekalert

Page: 1

Related medicine news :

1. Psychiatrists failing to adequately monitor patients for metabolic side-effects of prescribed drugs
2. Schools failing pupils with sickle cell disease
3. U.S. Failing to Meet Goals for Womens Health: Report
4. FDA Failing to Monitor Safety of Medical Devices: Report
5. Jill Greenfield Comments on the Numerous Failings Highlighted by the Griffin Inquiry into Godstone Farm E.Coli 0157 Outbreak
6. Pew Report: Louisiana Failing to Address Childrens Dental Health Crisis
7. Pew Report: Pennsylvania Failing to Address Childrens Dental Health Crisis
8. Pew Report: New Jersey Failing to Address Childrens Dental Health Crisis
9. Pew Report: Florida Failing To Address Childrens Dental Health Crisis
10. NEJM Publishes Trial Results Demonstrating Bard FLAIR Endovascular Stent Graft Is Superior To Balloon Angioplasty For Failing Dialysis Grafts
11. Averting bridge disasters: New technology could save hundreds of lives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... University] As Congress adjourns this month for the ... step over on their way out the chamber door ... Medicare Provider Payment Modernization Act of 2014. In a ... Dr. Eli Adashi recounts what he and other advocates ... The perennial trouble with how Medicare pays doctors will ...
(Date:9/17/2014)... 17, 2014 Wright hip lawsuit ... of metal-on-metal hip replacements continue to grow in ... Court, Northern District of Georgia, Bernstein Liebhard LLP ... by the U.S. Judicial Panel on Multidistrict Litigation ... liability claims have been filed in the proceeding ...
(Date:9/17/2014)... 2014 Boston Children’s Museum and ... monthly concert series, introducing young Museum visitors to ... America’s premier national platform celebrating the stories, talents, ... the young musicians featured will also be showcased ... Museum is fortunate to partner with the wonderful ...
(Date:9/17/2014)... Austin, TX (PRWEB) September 17, 2014 ... the Editor’s Picks by Progressive Grocer, a leading trade ... Pizza was awarded for originality and flavor, among other ... featured as an Editor’s Pick in the September print ... Progressive Grocer website. , The pizza won based on ...
(Date:9/17/2014)... 17, 2014 StartX , a ... companies raising rounds of funding at its Summer Demo ... investors and media, was the first such gathering held ... to the university. The presentations were delivered on an ... StartX-QB3 Labs, a 2,000 square foot life science facility ...
Breaking Medicine News(10 mins):Health News:Failed Medicare payments law remains relevant 2Health News:Failed Medicare payments law remains relevant 3Health News:Wright Hip Lawsuit News: Nearly 400 Filings Reported in Federal Wright Conserve Hip Replacement Litigation, Bernstein Liebhard LLP Reports 2Health News:Wright Hip Lawsuit News: Nearly 400 Filings Reported in Federal Wright Conserve Hip Replacement Litigation, Bernstein Liebhard LLP Reports 3Health News:Boston Children's Museum Partners with From the Top to Offer Monthly Concert Series 2Health News:Boston Children's Museum Partners with From the Top to Offer Monthly Concert Series 3Health News:Smart Flour Foods Wins 2014 Progressive Grocer Editor’s Pick Award 2Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 2Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 3Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 4Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 5Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 6
... Veto Will Deprive Six Million American Children of Healthcare ... of,Child and Adolescent Psychiatry strongly urges Congress to override,President ... 976) act., The House passed the S-CHIP bill ... enough to override the President,s veto. The Senate passed ...
... Pam Brady,President of the California State PTA, ... federal legislation to expand the State,Children,s Health Insurance ... morning of legislation to expand the SCHIP,program is ... families,including approximately 800,000 in California, who need medical ...
... Oct. 3 Prominent cosmetic dentist Dr. William,Hoskyns has ... partner.,Dr. Hoskyns joins Dr. Debra Gray King and her ... Arizona where he had an international,reputation as the dentist ... reconstruction. Well known for his celebrity and high ...
... Medical,Technologies, Inc. (Nasdaq: VNUS ), a leading provider ... reflux disease, today,announced that it presented at the William ... ET on October 3, 2007, at the New York,Palace ... of the VNUS presentation webcast is available on the,corporate ...
... Effective in High Risk Angioplasty Patients, TORONTO, ... over the,past year about the safety and potential ... possible fatal blood clots, even years,after an angioplasty ... from Ontario,s Institute for Clinical Evaluative Sciences,(ICES) and ...
... 3 The American Health Information,Management Association ... assessment and training consultation services for the,Centers ... AHIMA,s signing of,a contract with the nation,s ... requires AHIMA to determine ICD-10,s,impact(s) on CMS; ...
Cached Medicine News:Health News:American Academy of Child and Adolescent Psychiatry Reacts to S-CHIP Veto 2Health News:Prominent Cosmetic Dentist Dr. William Hoskyns Joins Leading Atlanta Practice 2Health News:New Canadian study finds drug coated heart stents to be safe: 2Health News:New Canadian study finds drug coated heart stents to be safe: 3Health News:New Canadian study finds drug coated heart stents to be safe: 4Health News:AHIMA Signs Contract With CMS for ICD-10 Implementation Assessment and Training 2
(Date:9/17/2014)... NEW YORK , Sept. 17, 2014  Levi ... ALXA) in connection with possible claims of breaches of ... Company. To get more information, click here: ... to you. If you own common stock ... information, please contact Eduard Korsinsky, Esq. either ...
(Date:9/17/2014)... Sept. 17, 2014 /PRNewswire-iReach/ -- ChemImage announced ... discussing improvements in the development of imaging ... both normal and diseased tissue that minimizes ... surgical procedures, lowers surgical costs and potentially ... The clinical and scientific ...
(Date:9/17/2014)... 2014 Bronstein, Gewirtz & Grossman, LLC is ... securities of PDL BioPharma, Inc. ("PDL BioPharma" or the ... are advised to contact Peretz Bronstein or ... info@bgandg.com or 212-697-6484. The investigation ... executives violated federal securities laws. On September ...
Breaking Medicine Technology:Patient Outcomes Improve When Molecular Chemical Imaging Technology Is Used to Aid Robotic Surgical Procedures, According to New White Paper 2Shareholder Alert: Bronstein, Gewirtz & Grossman, LLC Investigates claims on behalf of Investors of PDL BioPharma, Inc. --PDLI 2
... Feb. 21, 2012 A collaboration between NineSigma and ... advance HIV vaccine research by identifying new approaches to ... provider of innovation services , NineSigma has connected ... and helped it identify two scientists who will receive ...
... #8116 -- Precyse, a leader in health information ... HIMSS 2012 Annual Conference and Exposition that the ... improvements in revenue cycle workflow, coding accuracy, and ... adopting Precyse,s integrated health information management (HIM) and ...
Cached Medicine Technology:IAVI and NineSigma Collaborate to Identify New Approaches to Developing AIDS Vaccines 2IAVI and NineSigma Collaborate to Identify New Approaches to Developing AIDS Vaccines 3IAVI and NineSigma Collaborate to Identify New Approaches to Developing AIDS Vaccines 4Growing List of Providers Accelerate Revenue Cycles, Improve Clinical Documentation Through True Computer-Assisted Coding with Natural Language Comprehension™ 2Growing List of Providers Accelerate Revenue Cycles, Improve Clinical Documentation Through True Computer-Assisted Coding with Natural Language Comprehension™ 3Growing List of Providers Accelerate Revenue Cycles, Improve Clinical Documentation Through True Computer-Assisted Coding with Natural Language Comprehension™ 4
... The Vitros ECi brings true ... to immunodiagnostic testing. Highly sensitive assays ... oncology and bone metabolism testing are ... under development. The Vitros ECi can ...
... is a flexible system that ... environments small hospitals, backup ... satellite locations. The Vitros 250 ... can be automated or placed ...
... an effort to improve on the ... toxicology, abused drugs, and immunosuppressants tests, ... which incorporates random access capabilities. Although ... undergone several important changes in the ...
The IMx system is an automated analyzer designed to perform microparticle enzyme immunoassay (MEIA), fluorescence polarization immunoassay (FPIA) and ion capture technologies....
Medicine Products: