Navigation Links
Failing to bridge the gap between test tubes, animals, and human biology

Reasoning used in many highly cited cancer publications to support the relevance of animal and test tube experiments to human cancer is questionable, according to a study by researchers from Universit Libre de Bruxelles published in the open-access journal PLoS Computational Biology on October 20th 2011.

Most experimental biomedical research is performed on animals or on cells living in test tubes due to the limits ethics guidelines place on experimental investigation on humans. Bridging the gap between these experiments and human biology is a major hurdle. A connection is often made using the prognostic value of molecular markerssets of genes whose activation is related to particular biological processes. Researchers first determine a cancer marker and then assess the ability of the marker to predict survival. The fact that the marker is prognostic is considered to be evidence that the particular biological process is an important driver of cancer.

The authors question this reasoning by highlighting that most whimsical molecular markers, for example genes associated with mice social behavior, are prognostic in human breast cancer. Moreover, they studied 47 markers published in leading scientific journals, representing various biological processes supposedly relevant to breast cancer. They confirmed their prognostic value, but found that 60% of them are not better than random markers devoid of any biological rationale. Thus, the prognostic ability of molecular markers in human breast cancer seems to convey little meaningful information relevant to the biological processes of breast cancer progression.

The study recognizes that some molecular markers are truly prognostic and act as a useful guide to breast cancer treatment, even though they may fail to support the causal role of specific biological mechanisms in human breast cancer progression.

Contact: Vincent Detours
Public Library of Science

Page: 1

Related medicine news :

1. Psychiatrists failing to adequately monitor patients for metabolic side-effects of prescribed drugs
2. Schools failing pupils with sickle cell disease
3. U.S. Failing to Meet Goals for Womens Health: Report
4. FDA Failing to Monitor Safety of Medical Devices: Report
5. Jill Greenfield Comments on the Numerous Failings Highlighted by the Griffin Inquiry into Godstone Farm E.Coli 0157 Outbreak
6. Pew Report: Louisiana Failing to Address Childrens Dental Health Crisis
7. Pew Report: Pennsylvania Failing to Address Childrens Dental Health Crisis
8. Pew Report: New Jersey Failing to Address Childrens Dental Health Crisis
9. Pew Report: Florida Failing To Address Childrens Dental Health Crisis
10. NEJM Publishes Trial Results Demonstrating Bard FLAIR Endovascular Stent Graft Is Superior To Balloon Angioplasty For Failing Dialysis Grafts
11. Averting bridge disasters: New technology could save hundreds of lives
Post Your Comments:
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative ... has initiated cultivation and processing operations at its production facility, and opened its ... Puradigm is the manufacturer of a complete system of proactive air and surface ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... National recruitment ... a life sciences executive with extensive sequencing and genomics experience, as Vice President of ... position, Ms. Hill will be responsible for leading the sales team in the commercialization ...
(Date:6/24/2016)... Gaithersburg, MD (PRWEB) , ... June 24, 2016 ... ... and protocols for human induced pluripotent stem (iPS) cells and other difficult to ... PluriQ™ G9™ Cloning Medium. The PluriQ™ G9™ Gene Editing System is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... inhaled drugs, announced today that it was added to ... its comprehensive set of U.S. and global equity ... an important milestone for Pulmatrix," said Chief Executive Officer ... of our progress in developing drugs for crucial unmet ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... 2022" report to their offering. ... with kidney failure, it replaces the function of kidneys by ... and thus the treatment helps to keep the patient body,s ... Increasing number of ESRD patients & substantial healthcare ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology: