Navigation Links
Factors increasing the risk of atrophic gastritis and intestinal metaplasia
Date:4/12/2010

Atrophic gastritis and intestinal metaplasia are two important precursory lesions in the process of intestinal type gastric cancer. However, the precise mechanism of the progression of these two lesions is still unclear, a few studies have investigated the risk of host gene polymorphism on the atrophic gastritis and intestinal metaplasia, but all of them are limited by their one-time point screen.

A research article to be published on April 14, 2010 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Ji-You Li from Beijing cancer hospital & institute, Peking University used PCR based DHPLC technique and 56 month follow-up data, to study the association between IL-8, MIF gene polymorphisms and progression of atrophic gastritis and intestinal metaplasia in a high risk population of gastric cancer. The article further investigate the relationship of Helicobacter pylori infection and gene polymorphism on the progression of atrophic gastritis and intestinal metaplasia.

The result shown that IL-8-251 AA genotype or IL-8-251 AA genotype together with IL-8-251 TA genotype significantly increased the risk of severe atrophic gastritis and intestinal metaplasia; MIF-173 CC genotype or MIF-173 CC genotype together with MIF-173 GC genotype also increased the risk of severe atrophic gastritis and intestinal metaplasia significantly. Interestingly, the risk of severe atrophic gastritis and intestinal metaplasia become more evident when Helicobacter pylori infection has been considered.

Due to the high prevalence of H. pylori infection, antibiotic resistance, and some potential drawbacks associated with H. pylori eradication therapy (eg. reflux esophagitis), this study may provide a reasonable basis for therapeutic decisions (eg. Helicobacter pylori eradication) at an early stage of precursory lesions of gastric cancer.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Obesity, Alcohol Among Factors Linked to Womens Gout Risk
2. Obesity, hypertension, alcohol and diuretic use -- gout risk factors for women
3. Senior Fear Factors: What Aging Americans Fear Most
4. 4 preventable risk factors reduce US life expectancy and lead to health disparities
5. 4 preventable risk factors reduce life expectancy in US and lead to health disparities
6. Numerous factors weighed when patients cannot make their own decisions
7. Transcription factors may dictate differences between individuals
8. Predisposing factors for conversion of mild cognitive impairment to AD identified
9. Federal Government Premium Review Ignores Real Factors Driving Healthcare Costs
10. H1N1 learnings: Risk factors for severe outcomes among patients admitted to hospital with H1N1
11. Early Factors Predict Later-Life Stroke Risk, from the Harvard Health Letter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... FL (PRWEB) , ... February 06, 2016 , ... ... pleased to announce the launch of a new DRTV campaign with Belly Bands. , ... having tried everything from sprays to puppy pads and find nothing works, get ...
(Date:2/5/2016)... Falls, NY & Salt Lake City, UT (PRWEB) , ... February ... ... Davis, Founder of Activz Whole-Food Nutrition , announced that the much-anticipated feature with ... on the New Really Cool Humans Amateur TV Network. , Each week, on his ...
(Date:2/5/2016)... ... February 05, 2016 , ... Looking for a last-minute Valentine’s Day ... tips of your toes. Foot massage, whether administered by a professional masseuse or a ... The American Board of Multiple Specialties in Podiatry (ABMSP) has taken the ...
(Date:2/5/2016)... ... 05, 2016 , ... In the fourth quarter of 2015, ... the La Valencia Hotel in San Diego, California to discuss changes in the ... most outstanding franchise, walking away with the coveted David Wright Award of Excellence. ...
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point Consulting, a leading ... Software & Services for HIT Implementation Support & Staffing report with an outstanding ... performance by healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 2016  Aralez Pharmaceuticals Inc. ("Aralez") today announced the ... Tribute Pharmaceuticals Canada Inc. ("Tribute") following approval of the ... The combined company will operate under Aralez Pharmaceuticals Inc. ... Canada , Ireland ... Under the terms of the Agreement and Plan of ...
(Date:2/5/2016)... , Feb. 5, 2016  Venice,s newest laser ... the first of its kind in the area ... through advanced laser treatment. The physician-owned and operated ... Suncoast by storm with its revitalizing skin ... advanced multi-wavelength Astanza Trinity technology. http://photos.prnewswire.com/prnh/20160204/329957 ...
(Date:2/5/2016)... Ind. , Feb. 5, 2016  Zimmer Biomet ... pricing of the previously announced underwritten secondary offering of ... its stockholders, consisting of affiliates of Blackstone and Goldman ... at an initial price of $96.45 per share. The ... the offering.  Neither Zimmer Biomet nor any of its ...
Breaking Medicine Technology: