Navigation Links
FSU scientist leads research on AIDS-related cancer
Date:6/3/2011

ted cells are typically recognized and then eliminated by our immune system," Chase explained. "But Dr. Zhu's group has shown that the KSHV
 ORF45 protein plays a role in preventing the immune system from recognizing infected cells and removing them."

Gaining a better understanding of just how that happens is a key component of the new NIH grant.

An earlier study by Zhu's research team found that the KSHV ORF45 protein "hijacks" the signaling pathways within cells that are critical for a cell's regulation of its multiple processes including what genes are expressed when and at what level, as well as what metabolic pathways will be turned on at any given time, and to what extent.

Now, Zhu's latest grant will help him to clarify the KSHV ORF45 protein's role not only within cellular signaling pathways but also in immune evasion the process by which an invading organism avoids or suppresses the host's immune responses to it.

Unlocking what once were the mysteries of the KSHV infection and replication are crucial to developing effective therapies because, despite the success of highly active antiretroviral therapy against HIV, KS remains a serious disease and the most common cancer among HIV/AIDS patients. KSHV also is associated with other human cancers such as primary effusion lymphoma and multicentric Castleman's disease.

In Africa, KS accounts for nearly half of the reported cancers and is the leading cause of cancer death in some areas. Current treatments for KSHV-associated diseases are not optimal because they don't attack the viral agent specifically.

"Dr. Zhu's work on KSHV ORF45 aims to give us a drug target that is specific to the virus," Chase said. "The newly funded studies should take
 him even closer to that goal."

Since 2008, nine papers coauthored by Zhu's research team have been featured in leading peer-reviewed publications, including the Journal of Virology, PLoS P
'/>"/>

Contact: Fanxiu Zhu
fzhu@bio.fsu.edu
850-644-6273
Florida State University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists identify overactive genes in aggressive breast cancers
2. Tie Between Biomarkers, Disease Often Overstated, Scientists Say
3. California scientists discover how vitamins and minerals may prevent age-related diseases
4. Scientists Discover Ultra-Bad Cholesterol
5. 3 renowned scientists recruited for cancer, physics and chemistry research at Rice
6. Scientists Appear One Step Closer to Reading Minds
7. Multitasking meds: Scientists discover how drug for leukemia, psoriasis, may tackle vascular disease
8. Scientists Find Molecular Similarities in Brains of Those With Autism
9. NIH scientists identify most proteins made by parasitic worm
10. Heart scientists discover protein that may be 1 cause of heart failure
11. Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
FSU scientist leads research on AIDS-related cancer
(Date:10/1/2014)... new genetic finding from Duke Medicine suggests that some ... might also be hard-wired to gain weight when exposed ... , An estimated 13 percent of people, all of ... knowing this could help them reduce heart disease with ... stress management. , "Genetic susceptibility, psychosocial stress and metabolic ...
(Date:10/1/2014)... Beverly Hills licensed Clinical Psychologist and nationally ... years of private practice in her Beverly Hills office ... greater joy and fulfillment in their relationships. Dr. Mojas ... suggestions for anyone who suspects they are in a ... or not, it’s not always easy to know when ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Between 23 ... in the U.S., according to figures from the National ... Diseases Association (AARDA), and many of them have something ... of having undiagnosed celiac disease. Gluten Free Therapeutics, ... awareness of undiagnosed celiac disease by publishing a series ...
(Date:10/1/2014)... Jupiter, FL (PRWEB) October 01, 2014 ... Begley, Jr., scheduled to broadcast on Monday, October 20, ... In this episode, Innovations will go behind the scenes ... prevention programs. This segment will explore the practical help ... young adults, which teaches the warning signs of abuse, ...
(Date:10/1/2014)... 01, 2014 Diet Doc understands that many ... lose weight and their dieting attempts could be easily sabotaged ... hormone diet treatments into their programs as a ... see fast and effective weight loss results, it also allows ... habits to maintain their weight for the future. , Earlier ...
Breaking Medicine News(10 mins):Health News:Gene interacts with stress and leads to heart disease in some people 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4
... Vietnam's first human death from bird flu in more than ... the virus that remains endemic in the country, experts said ... capital Hanoi was killed by the H5N1 strain a week ... known to have been infected with the virus since last ...
... China's biggest lakes are under renewed attack from toxic ... humans in the country's latest pollution scare, state media ... China show the blue-green foul-smelling algae spreading in Taihu ... ,The toxic algae scare in Lake Taihu has ...
... is becoming increasingly popular.,More than three million babies worldwide ... , ovulation induction and intra-uterine induction. ,In ... births every year 10,242 in 2004 while ... among women under 35 is 28.2 per cent, falling ...
... US importer RC2 Corp based in Oak Brook, Illinois, in ... voluntarily recalled 1.5 million "Thomas and Friends" wooden train ... a toxic, lead-based paint. ,The toys, wooden vehicles, ... January 2005 and April 2007, pose a danger to young ...
... surgeries and operations could prove deadly for anaemic older men. ... with even slightly irregular red blood counts are at ... ,The study, which examined data from 310,311 men aged 65 ... minor anaemia or polycythemia, when the blood count is higher ...
... surgeon said troops injured in the battlefields of Iraq ... transported to field hospitals, newspapers reported Sunday . American ... were treated far more quickly than British soldiers nowadays, ... Colonel Paul Parker as saying. ,Parker cited ...
Cached Medicine News:Health News:Vietnam Bird Flu Death a Call for Action, Say Experts 2Health News:Vietnam Bird Flu Death a Call for Action, Say Experts 3Health News:Questions Raised Over Safety of In-vitro Fertilization 2Health News:Questions Raised Over Safety of In-vitro Fertilization 3Health News:Questions Raised Over Safety of In-vitro Fertilization 4Health News:Lead Scare Causes Thomas to Derail 2Health News:Major Surgeries and Operations Could Prove Deadly for Anaemic Older Men 2Health News:Wounded British Troops Wait Hours to Reach Hospital 2
(Date:9/30/2014)... Sept. 30, 2014 Arbor Pharmaceuticals, LLC. ... Global Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - ... of the Arbor Pharmaceuticals, LLC.,s pharmaceutical research and ... on the current therapeutic developmental pipeline of Arbor ... stages, therapeutics assessment by drug target, mechanism of ...
(Date:9/30/2014)... DENVER , Sept. 30, 2014  According ... "the world of cancer clinical trials is going ... clinical trials and the work of the current ... these types of ,next generation, clinical trials, which ... tomorrow."  The company has been ...
(Date:9/30/2014)... , Sept. 30, 2014 A study ... (OCT), offered a new look at the composition of ... how physicians understand and treat the disease, a leading ... at Baptist Health Lexington between September 2010 and May ... the Journal of the American College of Cardiology ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2
... Combination with CRESTOR (rosuvastatin calcium) Demonstrates Similar Lipid Effects ... ... Population, SAN FRANCISCO, June 7 ... type 2 diabetes,that were enrolled in a Phase III study showed ...
... the ADA,s Annual Scientific Sessions, SAN FRANCISCO, ... of the dose-finding study for its new,injectable diabetes ... American Diabetes Association,s (ADA) 68th Annual Scientific Sessions,meeting ... that AVE0010 was well tolerated and significantly,improved glycemic ...
Cached Medicine Technology:Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 2Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 3Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes 4New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 2New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 3New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: