Navigation Links
FSU scientist leads research on AIDS-related cancer
Date:6/3/2011

ted cells are typically recognized and then eliminated by our immune system," Chase explained. "But Dr. Zhu's group has shown that the KSHV
 ORF45 protein plays a role in preventing the immune system from recognizing infected cells and removing them."

Gaining a better understanding of just how that happens is a key component of the new NIH grant.

An earlier study by Zhu's research team found that the KSHV ORF45 protein "hijacks" the signaling pathways within cells that are critical for a cell's regulation of its multiple processes including what genes are expressed when and at what level, as well as what metabolic pathways will be turned on at any given time, and to what extent.

Now, Zhu's latest grant will help him to clarify the KSHV ORF45 protein's role not only within cellular signaling pathways but also in immune evasion the process by which an invading organism avoids or suppresses the host's immune responses to it.

Unlocking what once were the mysteries of the KSHV infection and replication are crucial to developing effective therapies because, despite the success of highly active antiretroviral therapy against HIV, KS remains a serious disease and the most common cancer among HIV/AIDS patients. KSHV also is associated with other human cancers such as primary effusion lymphoma and multicentric Castleman's disease.

In Africa, KS accounts for nearly half of the reported cancers and is the leading cause of cancer death in some areas. Current treatments for KSHV-associated diseases are not optimal because they don't attack the viral agent specifically.

"Dr. Zhu's work on KSHV ORF45 aims to give us a drug target that is specific to the virus," Chase said. "The newly funded studies should take
 him even closer to that goal."

Since 2008, nine papers coauthored by Zhu's research team have been featured in leading peer-reviewed publications, including the Journal of Virology, PLoS P
'/>"/>

Contact: Fanxiu Zhu
fzhu@bio.fsu.edu
850-644-6273
Florida State University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists identify overactive genes in aggressive breast cancers
2. Tie Between Biomarkers, Disease Often Overstated, Scientists Say
3. California scientists discover how vitamins and minerals may prevent age-related diseases
4. Scientists Discover Ultra-Bad Cholesterol
5. 3 renowned scientists recruited for cancer, physics and chemistry research at Rice
6. Scientists Appear One Step Closer to Reading Minds
7. Multitasking meds: Scientists discover how drug for leukemia, psoriasis, may tackle vascular disease
8. Scientists Find Molecular Similarities in Brains of Those With Autism
9. NIH scientists identify most proteins made by parasitic worm
10. Heart scientists discover protein that may be 1 cause of heart failure
11. Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
FSU scientist leads research on AIDS-related cancer
(Date:12/20/2014)... holidays can be anything but joyous for people with ... and other allergy triggers. "The dust from the ... away in dank basements or dusty attics is triggering ... Shah, an affiliate faculty member at Loyola University Chicago ... Shah, who is also an allergist at Gottlieb ...
(Date:12/20/2014)... The Doctor’s Office Urgent Care of Paramus, New Jersey has ... They’ve treated over 40,000 patients while carrying out their ... to the Paramus area. , For 2015, the practice ... of top-notch board certified physicians: Christine Milosis MD, Sandra Ugras ... doctors will work tirelessly to carry out The Doctor’s ...
(Date:12/20/2014)... 2014 As Risperdal lawsuits ( ... U.S. courts, Bernstein Liebhard LLP notes the publication ... treated with the medication may experience elevated levels ... and lactation. The study, which appears in International ... who began treatment with risperidone, an antipsychotic medication ...
(Date:12/20/2014)... 20, 2014 The aftermath of the November ... stir, not only in Hollywood, but worldwide. As ... the ripples of that attack are starting a finger-pointing game ... risk. But they are not the only ones affected, ... in for some embarrassing times ahead, agents and lawyers could ...
(Date:12/20/2014)... Aliso Viejo, California (PRWEB) December 20, 2014 ... have announced the release of a new plugin for ... Pixel Film Studios. , “TranSlice Volume 5 allows users ... literally hand draw it.” Said Christina Austin, CEO of ... to add level of professionalism while maintaining an easy ...
Breaking Medicine News(10 mins):Health News:Holiday Trimmings Can Trigger Allergies 2Health News:The Doctor's Office Urgent Care Adds 3 New Physicians to Their Growing Medical Team 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Publication of Study Suggesting Medication May Raise Prolactin Levels in Children 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:Pixel Film Studios released a new transition entitled TranSlice Volume 5 exclusively for Final Cut Pro X 2
... researchers have identified an unexpected molecular marker that ... to chemotherapy. Triple-negative breast cancers --which do ... progesterone receptor and do not have Her2/neu overexpression ... of the disease and cannot be treated with ...
... By Amanda Gardner HealthDay Reporter , WEDNESDAY, ... early stage prostate cancer, those who have the prostate gland ... a "watchful waiting" approach, according to a new long-term study ... to be practice-changing, said Dr. Richard E. Greenberg, chief of ...
... Gardner HealthDay Reporter , WEDNESDAY, May 4 ... was able to rectify ventricular fibrillation, a severely abnormal ... none experienced sudden death, according to new research. ... is already approved in Europe and is undergoing review ...
... May issue of the journal Health Affairs , Mount ... of toxic chemicals and air pollutants in the environment, and ... also those already on the market. Leonardo Trasande, ... Sinai School of Medicine, analyzed the costs of conditions ...
... MOINES, Iowa, May 4, 2011 The Donald Danforth Plant ... from the Howard G. Buffett Foundation to bring healthier sorghum ... help fund the completion of the development of biofortified sorghum, ... upon sorghum as their staple diet. DuPont business Pioneer ...
... Translational Genomics Research Institute (TGen) has licensed its first ... modifying the actions of proteins. Today,s announcement is ... laboratory discoveries more rapidly into therapeutics that can immediately ... drug, ONCO-101, is being licensed to Syracuse, N.Y.-based Oncoholdings ...
Cached Medicine News:Health News:Gene expression predicts chemotherapy sensitivity of triple-negative breast cancer 2Health News:Aggressive Treatment May Be Beneficial for Early Prostate Cancer 2Health News:Aggressive Treatment May Be Beneficial for Early Prostate Cancer 3Health News:New Defibrillator Shows Promise in Small Study 2Health News:Estimated costs of environmental disease in children at $76.6 billion per year 2Health News:Estimated costs of environmental disease in children at $76.6 billion per year 3Health News:Grant funds next phase in bringing healthier sorghum closer to underserved communities 2Health News:TGen licenses first drug for patient use in clinical care 2
(Date:12/19/2014)... Fla. , Dec. 19, 2014 Breckenridge ... a multi-product agreement with MSN Laboratories Pvt. Ltd. ( ... MSN expect to commercialize several new ANDAs.  Under the ... supply the products exclusively to Breckenridge for the U.S. ... under its label.  Breckenridge and MSN have agreed to ...
(Date:12/19/2014)... , Dec. 19, 2014  Monarch America Inc. (OTCQB: ... Corp.) is pleased to provide this review of the ... in 2015. "Over this past year, we ... I am extremely proud to say that Monarch America ... than it has ever been," stated Eric Hagen ...
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research ... announced the addition of the "Micro Market ... report to their offering. ... dermatological treatment is progressing steadily, which has resulted ... diagnostic devices market. The main purpose of these ...
Breaking Medicine Technology:Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3
... 2007 - Geron,Corporation (Nasdaq:GERN) today announced the ... company's human,embryonic stem cell (hESC)-based therapeutic for ... direct attack by the human immune,system., Presented ... Federation of,Clinical Immunology Societies meeting in San ...
... BETHESDA, Md., June 11, 2007--New research supported ... of Arthritis and,Musculoskeletal and Skin Diseases (NIAMS) ... which is used for certain,types of seizures, ... pain and,other symptoms associated with the common, ...
Cached Medicine Technology:Research Indicates Geron's Human Embryonic Stem Cell-Based,Therapeutic for Spinal Cord Injury Evades Direct Attack by the,Human Immune System 2Research Indicates Geron's Human Embryonic Stem Cell-Based,Therapeutic for Spinal Cord Injury Evades Direct Attack by the,Human Immune System 3Gabapentin Shown Effective for Fibromyalgia Pain 2Gabapentin Shown Effective for Fibromyalgia Pain 3
Inquire...
... incubators,Two refrigerated incubators that are ... life cycle,testing. Microprocessor controlled heating ... display. High/low audible and visual ... internal chamber safety thermostat,provides over-temperature ...
Inquire...
Inquire...
Medicine Products: