Navigation Links
FSU researcher's 'mutant' proteins could lead to new treatment for heart disease
Date:3/24/2008

TALLAHASSEE, Fla. -- Heart damage due to blocked arteries remains the leading cause of disease and death in the Western world, but a Florida State University College of Medicine researcher is helping to open new pathways toward treating the problem.

Michael Blaber, a professor in the department of biomedical sciences, is researching mutant forms of a human protein that have been shown to help the human body grow new blood vessels to restore blood flow in damaged areas of the heart.

Working with a $264,000, three-year grant from the American Heart Association, Blaber hopes to provide data that will enable the use of the mutant proteins in new treatment methods previously unavailable for patients with advanced no option heart disease.

This research offers the potential to treat people who currently are being sent home to die, Blaber said. Weve tested a group of mutants in the laboratory with unusual properties of increased stability and activities -- good properties. In some cases it was unexpected, but the results are very promising.

Obstructed blood vessels and clogged or blocked arteries typically are treated through angioplasty, the mechanical widening of a vessel, or bypass surgery. Some patients, however, have numerous small blockages that cannot be treated through traditional approaches. In most cases, they are sent home with a predicted life expectancy that, no matter how its phrased, sounds like a death sentence.

A new approach to the problem called therapeutic coronary angiogenesis is creating hope through the injection of human fibroblast growth factor protein into affected areas. Improvements with the procedure may arise from the use of mutant forms with increased stability.

Blaber and his research team are creating artificial mutant proteins in their College of Medicine laboratory that mimic the human proteins used in angiogenic therapy, and with enhanced stability properties. So far, the mutant proteins engineered at the College of Medicine have exhibited potency in stimulating cell growth while simultaneously maintaining greater stability under conditions common to angiogenic therapy.

The work has enormous potential commercial applications and already has drawn the attention of private companies interested in the results Blabers lab has achieved and the intellectual properties his studies are generating.


'/>"/>

Contact: Doug Carlson
doug.carlson@med.fsu.edu
850-645-1255
Florida State University
Source:Eurekalert

Related medicine news :

1. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
2. Researchers Gain Insights Into On-Off Switch for Cells
3. Molecular science could further improve leukemia survival, say St. Jude researchers
4. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
5. Recognizing outstanding young researchers
6. Researchers sharpen search for new marine medicines with novel techniques
7. Global Sound Conference Brings Worlds Top Sound Researchers, Technologists and Musicians to Los Angeles for Four Day Symposium
8. Queensland researchers get the latest tools to fight cancer
9. Researchers find 1 in 6 women, 1 in 10 men at risk for Alzheimers disease in their lifetime
10. Researchers discover second depth-perception method in brain
11. Researchers study new drug and indications for heated chemotherapy treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... ... Elder-Beerman, Herberger’s and Younkers department stores, announced it has raised $176,000 to benefit ... Center, Holden Comprehensive Cancer Center at the University of Iowa, The Lynn Sage ...
(Date:2/9/2016)... ... 09, 2016 , ... METTLER TOLEDO has published a new ... basic understanding of the techniques they use so they can more easily spot ... waste and rework to create a leaner overall lab experience. , The ...
(Date:2/9/2016)... ... 2016 , ... United Methodist Communications collaborated with Chocolate Moose ... video designed to prevent the next widespread Ebola outbreak from occurring ... distributed throughout Togo, Liberia, Sierra Leone, Nigeria, Côte d’Ivoire and other African countries, ...
(Date:2/9/2016)... Petersburg, FL (PRWEB) , ... February 09, 2016 , ... Shark Finds and ... a new DRTV campaign with GRIP-DRY. , GRIP-DRY is a newly patented product that has ... Golfers who play in the wet and early morning dew or right after a rain ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Federal Laboratory ... federallabs.org . The site houses a wealth of federal resources that businesses can ... process called technology transfer (T2). As a network of over 300 federal laboratories, ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016  Increasingly, health care ... their vital signs with wireless technology. With the Vios ... automate patient oversight and remotely detect problems before they ... signs across in-hospital environments. the United ... United States . --> The ...
(Date:2/9/2016)... Feb. 9, 2016 The new report " Global Fetal ... Spearhead Acuity Business Research & Consulting group reveals that ... market with a share of 36.4% in 2014 that translated into ... , the report also covers market analysis for Fetal and Neonatal ... , Asia-Pacific , Latin America ...
(Date:2/9/2016)... , Feb. 9, 2016  Bluestar Silicones will promote ... line for long-term implant applications and announce certification ... & Manufacturing (MD&M) West Conference (Booth #1759), February ... --> --> Available in ... LSRs offer outstanding physical properties enabling our customers ...
Breaking Medicine Technology: