Navigation Links
FSU researcher's 'mutant' proteins could lead to new treatment for heart disease
Date:3/24/2008

TALLAHASSEE, Fla. -- Heart damage due to blocked arteries remains the leading cause of disease and death in the Western world, but a Florida State University College of Medicine researcher is helping to open new pathways toward treating the problem.

Michael Blaber, a professor in the department of biomedical sciences, is researching mutant forms of a human protein that have been shown to help the human body grow new blood vessels to restore blood flow in damaged areas of the heart.

Working with a $264,000, three-year grant from the American Heart Association, Blaber hopes to provide data that will enable the use of the mutant proteins in new treatment methods previously unavailable for patients with advanced no option heart disease.

This research offers the potential to treat people who currently are being sent home to die, Blaber said. Weve tested a group of mutants in the laboratory with unusual properties of increased stability and activities -- good properties. In some cases it was unexpected, but the results are very promising.

Obstructed blood vessels and clogged or blocked arteries typically are treated through angioplasty, the mechanical widening of a vessel, or bypass surgery. Some patients, however, have numerous small blockages that cannot be treated through traditional approaches. In most cases, they are sent home with a predicted life expectancy that, no matter how its phrased, sounds like a death sentence.

A new approach to the problem called therapeutic coronary angiogenesis is creating hope through the injection of human fibroblast growth factor protein into affected areas. Improvements with the procedure may arise from the use of mutant forms with increased stability.

Blaber and his research team are creating artificial mutant proteins in their College of Medicine laboratory that mimic the human proteins used in angiogenic therapy, and with enhanced stability properties. So far, the mutant proteins engineered at the College of Medicine have exhibited potency in stimulating cell growth while simultaneously maintaining greater stability under conditions common to angiogenic therapy.

The work has enormous potential commercial applications and already has drawn the attention of private companies interested in the results Blabers lab has achieved and the intellectual properties his studies are generating.


'/>"/>

Contact: Doug Carlson
doug.carlson@med.fsu.edu
850-645-1255
Florida State University
Source:Eurekalert

Related medicine news :

1. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
2. Researchers Gain Insights Into On-Off Switch for Cells
3. Molecular science could further improve leukemia survival, say St. Jude researchers
4. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
5. Recognizing outstanding young researchers
6. Researchers sharpen search for new marine medicines with novel techniques
7. Global Sound Conference Brings Worlds Top Sound Researchers, Technologists and Musicians to Los Angeles for Four Day Symposium
8. Queensland researchers get the latest tools to fight cancer
9. Researchers find 1 in 6 women, 1 in 10 men at risk for Alzheimers disease in their lifetime
10. Researchers discover second depth-perception method in brain
11. Researchers study new drug and indications for heated chemotherapy treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... The Smart ... unemployment—researchers from Oxford University predict that 47 percent of all jobs in the United ... redefining “smart” and “successful.” The day of the aggressive know-it-all who steamrolls over colleagues ...
(Date:2/24/2017)... Viejo, CA (PRWEB) , ... February 24, 2017 , ... ... Final Cut Pro X . Users have total control over position, rotation, distortion, ... and more all within Final Cut Pro X. , With ProGlass Prism users are ...
(Date:2/24/2017)... ... 24, 2017 , ... The Radiology Business Management Association will select ... the annual Building Better Radiology Marketing Programs conference, held this year from ... Texas. Nine awards are given out in five categories. They are:, ...
(Date:2/23/2017)... ... February 23, 2017 , ... On February 22, 2017 ... letter to withdraw previous guidance issued by the Obama Administration requiring schools ... in May 2016 by the Obama Administration came in response to a growing ...
(Date:2/23/2017)... CA (PRWEB) , ... February 23, 2017 , ... Los ... two episodes of WE TV’s “Mama June: From Not to Hot,” which will begin ... notable, “Mama” June Shannon, known to millions from the 2012 reality television series, “Here ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017 Following receiving ... , s AMAR is a major milestone for ... M w ound care market in ... BST for inclusion in the National Health Basket , ...   E-QURE Corp. (OTCQB: EQUR), a leader in medical ...
(Date:2/24/2017)... Feb. 24, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, will present at the Cowen and Company 37 ... Marriott Copley Place on Tuesday, March 7, 2017 at ... webcast of the presentation can be accessed at ... following the conference via Zimmer Biomet,s Investor Relations website ...
(Date:2/24/2017)... Research and Markets has announced the addition of the "Hemophilia ... ... Drugs Price Analysis and Strategies - 2016, provides drug pricing data and ... questions: What are the key drugs marketed ... Global Hemophilia market? What are the unit prices and ...
Breaking Medicine Technology: