Navigation Links
FSU researcher's 'mutant' proteins could lead to new treatment for heart disease
Date:3/24/2008

TALLAHASSEE, Fla. -- Heart damage due to blocked arteries remains the leading cause of disease and death in the Western world, but a Florida State University College of Medicine researcher is helping to open new pathways toward treating the problem.

Michael Blaber, a professor in the department of biomedical sciences, is researching mutant forms of a human protein that have been shown to help the human body grow new blood vessels to restore blood flow in damaged areas of the heart.

Working with a $264,000, three-year grant from the American Heart Association, Blaber hopes to provide data that will enable the use of the mutant proteins in new treatment methods previously unavailable for patients with advanced no option heart disease.

This research offers the potential to treat people who currently are being sent home to die, Blaber said. Weve tested a group of mutants in the laboratory with unusual properties of increased stability and activities -- good properties. In some cases it was unexpected, but the results are very promising.

Obstructed blood vessels and clogged or blocked arteries typically are treated through angioplasty, the mechanical widening of a vessel, or bypass surgery. Some patients, however, have numerous small blockages that cannot be treated through traditional approaches. In most cases, they are sent home with a predicted life expectancy that, no matter how its phrased, sounds like a death sentence.

A new approach to the problem called therapeutic coronary angiogenesis is creating hope through the injection of human fibroblast growth factor protein into affected areas. Improvements with the procedure may arise from the use of mutant forms with increased stability.

Blaber and his research team are creating artificial mutant proteins in their College of Medicine laboratory that mimic the human proteins used in angiogenic therapy, and with enhanced stability properties. So far, the mutant proteins engineered at the College of Medicine have exhibited potency in stimulating cell growth while simultaneously maintaining greater stability under conditions common to angiogenic therapy.

The work has enormous potential commercial applications and already has drawn the attention of private companies interested in the results Blabers lab has achieved and the intellectual properties his studies are generating.


'/>"/>

Contact: Doug Carlson
doug.carlson@med.fsu.edu
850-645-1255
Florida State University
Source:Eurekalert

Related medicine news :

1. NYU dental researchers find evidence of periodontal disease leading to gestational diabetes
2. Researchers Gain Insights Into On-Off Switch for Cells
3. Molecular science could further improve leukemia survival, say St. Jude researchers
4. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
5. Recognizing outstanding young researchers
6. Researchers sharpen search for new marine medicines with novel techniques
7. Global Sound Conference Brings Worlds Top Sound Researchers, Technologists and Musicians to Los Angeles for Four Day Symposium
8. Queensland researchers get the latest tools to fight cancer
9. Researchers find 1 in 6 women, 1 in 10 men at risk for Alzheimers disease in their lifetime
10. Researchers discover second depth-perception method in brain
11. Researchers study new drug and indications for heated chemotherapy treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... 2017 , ... International Protein, a company based out of Australia that focuses ... January ECRM trade show in Hilton Head, SC. , International Protein was founded ... a line of products that would elevate her fitness regime. At this ECRM trade ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... sugar-free alternative VW+ 002. The drinks have been produced in collaboration with Zlatan ... perform during your workout. , After a successful launch in Sweden last year, ...
(Date:1/20/2017)... ... 20, 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went ... creation of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age ... at 19 years of age, he joined the Navy and got married right out of ...
(Date:1/20/2017)... ... ... in Suffolk”: a story of love, secrets, and mystery. “Christmas in Suffolk” is ... works in a daycare and looks for inspiration in the local coffee shop as ... Seymour’s new book is an adventure of love and secrets. , After ...
(Date:1/20/2017)... ... ... “The Land of More and More”: a brilliant story for children and adults ... and achievable answer. “The Land of More and More” is the creation of published ... Indiana where he works with the children’s ministry department. , Michael says that ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 19, 2017 ViewRay, Inc. ... a federal institution supporting research in Germany ... and patient treatments at the University Clinic Heidelberg as ... The MRIdian Linac program will be headed by ... also heads radiation oncology at the German Cancer Research ...
(Date:1/19/2017)... 19, 2017   Science Exchange , the leading ... that the first five replication studies from the ... published in eLife today. Despite intense scrutiny around ... practical evaluation of reproducibility rates that may identify ... other assessments of reproducibility, the results of this ...
(Date:1/19/2017)... , January 19, 2017 ... Option to Address Motor Symptoms and Motor Complications ... ...      (Logo: http://photos.prnewswire.com/prnh/20151014/276718LOGO) ... , European Neurological Review,2016;11(Suppl. 2): 2-15, http://www.touchneurology.com/articles/safinamide-new-therapeutic-option-address-motor-symptoms-and-motor-complications-mid-late ...
Breaking Medicine Technology: