Navigation Links
FOXO factor promotes survival of oxygen-deprived cancer cells
Date:12/27/2007

Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on the growth of tumors, depending on whether or not the tumor cells have enough oxygen. The research, published by Cell Press in the December 28th issue of Molecular Cell, provides critical new information about how normal cells and cancer cells survive under stress.

Dividing tumor cells are often deprived of oxygen as a result of their rapid expansion or aberrant blood vessels. Response to stressful low oxygen conditions, known as hypoxia, involves expression of several genes that enable cells to adapt to the oxygen deficit. This response is primarily mediated by the hypoxia-inducible transcription factors, HIF1 and HIF2.

HIF proteins play a key role in hypoxic tumor development and are often associated with poor patient prognosis. Hypoxic tumor cells exhibit decreased sensitivity to radiation and chemotherapy, and increased potential for invasion and metastasis. Interestingly, recent research findings have also revealed an anti-cancer role for HIF1 that is mediated by the initiation of programmed cell death, called apoptosis, in response to severe hypoxic stress. Although HIF1 has been linked to several pro-apoptotic target genes, specific mechanisms that regulate this particular function of HIF1 are not well understood.

Dr. Tak W. Mak from the Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital in Toronto and colleagues found that hypoxia stimulates an HIF1-dependent increase in a protein called FOXO3a. FOXO transcription factors are evolutionarily conserved proteins that are critical regulators of cell survival under stressful conditions. Recently, FOXO proteins have also been shown to act as tumor suppressors.

Dr. Maks group observed that under hypoxic conditions, FOXO3a inhibited HIF-1 induced apoptosis in normal cells and breast cancer cells by stimulating the transcrip
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Study, meta-analysis examine factors associated with death from heatstroke
3. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
4. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
5. PA Health Department Survey Shows Impact of Income, Gender, Other Factors on Health and Access to Health Care
6. Researchers genetically engineer micro-organisms into tiny factories
7. Study Downgrades Gene as Heart Risk Factor
8. Severe heart defect likely caused by genetic factors
9. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
10. Aggressively Treating Cardiac Risk Factors May Reverse Ischemia
11. New peptide communication factor enabling bacteria to talk to each other discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... analysis of hepatitis E virus (HEV) transmission by blood ... England have HEV in their plasma. The findings, published ... HEV-containing blood components (eg, red cells, platelets, and fresh ... in England. , The study retrospectively screened 225 ... between Oct, 2012 and Sept, 2013 for HEV RNA. ...
(Date:7/27/2014)... 2014 The report, “Glass Fiber ... By Raw Material, By Manufacturing Process, By Application ... By Geography – Global Trends & Forecast to ... market with an analysis and forecast by value ... and 107 figures spread through 347 slides and ...
(Date:7/27/2014)... medication to treat asthma and pneumonia can become ineffective. , ... drugs widely used to treat lung diseases work with the ... is caused by an infection, affects around 1 in 1000 ... children, the elderly, smokers and those with an underlying health ... UK are affected by asthma and the NHS spends around ...
(Date:7/27/2014)... Over the past five years, the ... well, thanks to many consumers valuing the taste and ... Coffee Association of Canada's Canadian Coffee Drinking Study in ... coffee per day. “This trend, coupled with many studies ... drinking tea on a daily basis, has stimulated consumer ...
(Date:7/27/2014)... 27, 2014 The report, “Oil Filter ... LCVs & HCVs), Market Type (OE & Aftermarket), Filter ... & Geography - Industry Trends & Forecast to 2018”, ... filters market with analysis and forecasting of the global ... is estimated to reach a revenue of $6.1 billion ...
Breaking Medicine News(10 mins):Health News:The Lancet: 1 in 3000 blood donors in England infected with hepatitis E 2Health News:Major Drivers for GFRP Composites Market in Future – Report by MarketsandMarkets 2Health News:Major Drivers for GFRP Composites Market in Future – Report by MarketsandMarkets 3Health News:Major Drivers for GFRP Composites Market in Future – Report by MarketsandMarkets 4Health News:Drugs used to treat lung disease work with the body clock 2Health News:Coffee and Tea Production in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Coffee and Tea Production in Canada Industry Market Research Report Now Available from IBISWorld 3Health News:Oil Filter & Fuel Filter Market Worth $18.6 Billion by 2018 - Report by MarketsandMarkets 2Health News:Oil Filter & Fuel Filter Market Worth $18.6 Billion by 2018 - Report by MarketsandMarkets 3Health News:Oil Filter & Fuel Filter Market Worth $18.6 Billion by 2018 - Report by MarketsandMarkets 4Health News:Oil Filter & Fuel Filter Market Worth $18.6 Billion by 2018 - Report by MarketsandMarkets 5
... U.S. households where English is not the primary language ... Medical Center researcher has found. , In a study ... Dr. Glenn Flores, professor of pediatrics at UT Southwestern ... of Children,s Health to examine whether disparities exist for ...
... BEDFORD, Mass., June 10 Insulet Corporation,(the "Company") (Nasdaq: ... a private,offering of $75 million in aggregate principal amount ... qualified institutional buyers in,reliance on Rule 144A under the ... the initial purchasers an option to purchase up to ...
... cardiac,arrest is a leading cause of death in ... it is imperative that every school develop an,emergency ... need to respond,effectively to children and adults who ... CPR and use an automated external defibrillator,(AED) are ...
... ,Best of Healthcare Furniture, ... Category for Third Straight ... by,Steelcase won the Gold Award in the Healthcare Furniture ... state-of-the-art product,design, technological innovation and environmental sustainability., (Photo: ...
... to kill cancer cells offer a promising strategy for ... body,s natural defenses often eliminate the viruses before they ... study by researchers at the Ohio State University Comprehensive ... improve this therapy for brain cancer patients. , The ...
... Snowe,(R-ME), member of the Senate Finance Committee, has ... pharmacy-related provisions to provide,prompt payment of Medicare Part ... Medicaid reimbursement cuts for generic prescription,drugs. In response, ... in,Camden, ME and a member of the National ...
Cached Medicine News:Health News:Children in non-English-speaking households face many health disparities, researcher concludes 2Health News:Insulet Corporation Announces Pricing of $75 Million of Convertible Senior Notes 2Health News:Insulet Corporation Announces Pricing of $75 Million of Convertible Senior Notes 3Health News:Statement of Robert O'Connor, M.D., M.P.H. Chair, American Heart Association, Emergency Cardiovascular Committee, on U.S. House of Representatives Passage of the Josh Miller HEARTS Act 2Health News:Three-peat: Nurture(R) Strikes Gold Again at NeoCon 2Health News:Cancer-killing viruses influence tumor blood-vessel growth 2Health News:Maine Community Pharmacy Owner Thanks Sen. Snowe for Supporting Inclusion of Common-Sense Reimbursement Provisions in Medicare Bill 2
(Date:7/25/2014)... 25, 2014  CVS Caremark Corporation (NYSE: ... Tuesday, August 5, 2014, at 8:30 a.m. (EDT) with ... financial results. An audio webcast of the ... Relations portion of the CVS Caremark website for all ... . This webcast will be archived and available on ...
(Date:7/25/2014)... , July 25, 2014 Cardinal Health will ... pharmacies as winners of its prestigious Independent Pharmacy Best ... , one of the nation,s largest gatherings of independent ... – family-owned pharmacies from Ohio , ... – were selected for implementing exceptionally creative ...
(Date:7/25/2014)... 25, 2014 According to a ... and China Insulin Market (Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting, Premixed, ... Growth, Trends and Forecast (Value and Volume), 2013 - ... 19.99 billion in 2012 and is expected to grow ... to reach USD 32.24 billion in 2019. ...
Breaking Medicine Technology:Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 2Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 3Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 4Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 5Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 6Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 2Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 4
... 18, 2011 Amarin Corporation plc (Nasdaq: AMRN ... disease, today reported positive, statistically significant top-line results from its ... Phase 3 trial met its primary and secondary efficacy endpoints ... The purpose of the ANCHOR trial was ...
... a speech delivered Wednesday, President Obama outlined a framework ... the President discussed Medicare and his proposals to decrease ... proposals is to "speed generic brands of medicine onto ... to his continued call to reduce the length of ...
Cached Medicine Technology:Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 2Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 3Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 4Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 5Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 6Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 7Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 8BIOCOM Response to Health Portion of President's Speech at George Washington University 2
... isotopic anemia assays feature ... ,pipetting steps for greater ... the processes ,involved in ... benefit to your laboratory ...
... Autoimmunity Screening Panel 1 is an ... and detection,of autoantibodies against various specific ... in serum, and is used,as an ... lupus erythematosus (SLE), mixed connective tissue ...
The MESACUP ANA Test Kit is a semi-quantitative enzyme-linked immunosorbent assay,(ELISA) for the detection of specific anti-nuclear antibodies in human serum as an aid in,the determination of autoim...
... are compatible with multichannel pipettors, which allows ... pipetting steps required to prepare and place ... Ask Immuno Concepts for more information about ... formats are noted with an * after ...
Medicine Products: