Navigation Links
FDG-PET appears promising for predicting prognosis of patients with inoperable NSCLC
Date:10/5/2011

Miami Beach, Fla. The prognosis for patients with stage II and III inoperable non-small cell lung cancer (NSCLC) is poor, with only about 15 percent of patients surviving at five years post-treatment for the disease. While new treatment strategies are being intensely studied, timely assessment of their efficacy has proven difficult. In a presentation today, Mitchell Machtay, MD, principal investigator of the ACRIN 6668/RTOG 0235 trial and RTOG deputy chair, reported the that post-treatment F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) scans show promise for predicting the prognosis of patients with inoperable disease.

"These results are encouraging," says Machtay. "Definitive prognostic information after a patient completes therapy has not been available for making decisions about further treatment options, and these preliminary results suggest that FDG-PET may play an important role in that regard."

Twenty ACRIN and RTOG participating sites enrolled 251 patients into the phase III trial that gathered pre- and post-treatment FDG-PET scans treatment included both chemotherapy and radiation therapy. Specifically, investigators sought to determine if the standardized uptake value (SUV), a quantitative measure of how rapidly tumor cells are using the glucose-based FDG radiotracer, obtained on post-treatment FDG-PET scans was predictive of a patient's survival. As Machtay reported, "The post-treatment scan was predictive for patients' prognosis by identifying that patients with high levels of FDG uptake following treatment had more aggressive tumors that were more likely to recur, and the higher the SUV measure in the primary tumor, the greater the recurrence rate and the lower a patient's corresponding survival outlook."

"The results announced today suggest that FDG-PET has a role in helping physicians make more informed treatment decisions, such as starting a patient on a new chemotherapy program," says Barry Siegel, MD, ACRIN co-deputy chair and medical director of the ACR PET Imaging Core Laboratory, "and helping investigators determine whether a treatment regimen is worthy of further study before long-term survival data are available."

The FDG-PET scan results provided for this analysis were interpreted by physicians at the participating sites. Further analyses are ongoing evaluating scan data interpreted by central review at the ACR Imaging Core Laboratory and using other semi-quantitative measures.


'/>"/>

Contact: Heather Curry
PR@acr.org
703-390-9822
American College of Radiology
Source:Eurekalert

Related medicine news :

1. Combining CT, FDG-PET provides more accurate treatments for head and neck cancer patients
2. FDG-PET/CT plays a definite role in detecting colorectal cancer recurrences
3. Breast Cancer Appears Less Deadly for Men Than Women
4. HRT therapy appears to increase risk of hospitalization from severe asthma attacks
5. For Young Breast Cancer Patients, Breast-Conserving Therapy Appears Effective
6. Even mild cognitive impairment appears to substantially increase risk for death
7. Brain Injury Appears to Boost Stroke Risk
8. Satisfaction with the components of everyday life appears protective against heart disease
9. Soluble Fiber Appears Key to Trimming Bad Fat
10. Mild obesity appears to improve survival in ALS patients
11. Flu Vaccine Appears Safe After Kidney Transplant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... The CFOs included on this ... systems in the nation and help their organizations navigate the challenges in healthcare ... instrumental in developing successful hospital and health system strategy. , Becker's Hospital Review ...
(Date:5/23/2017)... CLARA, CA (PRWEB) , ... May 23, 2017 , ... ... and financial organizations, today announced CIO Applications magazine has named the company a ... its innovative use of the Cloud to help organizations simply and proactively address potential ...
(Date:5/23/2017)... Santa Rosa, California (PRWEB) , ... May 23, ... ... population health management (PHM) technology and a 2017 Best in KLAS category winner, ... an advantageous market position to extend and enhance its technology platform and product ...
(Date:5/23/2017)... ... 23, 2017 , ... Drs. Allen Huang and Jeffrey Wang, ... Las Vegas, NV, and the importance of treating it immediately. They are now ... for peri-implantitis, with or without a referral. As experienced periodontists and implant specialists, ...
(Date:5/23/2017)... San Diego, CA (PRWEB) , ... May 23, 2017 , ... ... including bleeding gums and chronic bad breath, can now receive laser gum disease treatments ... Addleson, R. Douglas Campbell and David Landau are raising awareness of the importance of ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... SAN DIEGO , May 4, 2017 /PRNewswire/ ... is demonstrating its wireless, handheld ultrasound scanners this ... Gynecologists Annual Scientific Meeting (ACOG) in ... 2017. "Clarius is the perfect ... fetal growth and heart rate, and evaluate pregnancy-related ...
(Date:5/4/2017)...  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... today announced that it is teaming up with Auto ... to lower diabetes healthcare costs in Canada ... is available throughout all provinces and territories in ... for additional savings when shopping for Dario supplies in ...
(Date:5/4/2017)... 4, 2017   BioLife Solutions , Inc. (NASDAQ: ... marketer of proprietary clinical grade hypothermic storage ... "Company"), today announced that the Company,s first quarter 2017 ... Thursday, May 11, 2017, and that the Company will ... p.m. PT that afternoon. Management will provide an overview ...
Breaking Medicine Technology: