Navigation Links
FDA to Review Clotting Drug After Trial Suggests Death Risk
Date:10/25/2007

>

In February, a study published in the Journal of the American Medical Association found patients on the drug were at greater risk of dying over the next five years than those given two other medications. The same researchers linked aprotinin to an increased risk of kidney failure, heart failure and stroke in a study published in 2006.

"Our present findings deal with death," one of the JAMA study's authors, Dr. Dennis T. Mangano, said at the time. Mangano, director of the Ischemia Research and Education Foundation, a California-based nonprofit group, said that "the death rate for aprotinin patients far outstrips that for the other two drugs."

His team's study tracked the long-term survival of nearly 3,900 heart patients who underwent coronary artery bypass surgery at 62 medical centers worldwide. The researchers tabulated survival at six weeks, six months, and then annually for five years.

The five-year death rate for patients given aprotinin was 20.8 percent, compared to 15.8 percent for those given another drug, aminocaproic acid, and 14.7 percent for those given tranexamic acid. Both alternative drugs are available in generic versions.

After the 2006 report from Mangano's group, the FDA advised doctors to carefully monitor aprotinin patients for kidney, heart and brain damage -- an action taken after Bayer Pharmaceuticals disclosed study data showing that it increased the risk of death, kidney damage, congestive heart failure and stroke.

The 2006 report led to a 37 percent reduction in surgeons' use of aprotinin, Mangano said. "Clinicians, more than anyone else, will decide whether this drug should be on the market or its use should be limited," he said.

Aprotinin does have its defenders.

Dr. T. Bruce Ferguson Jr., associate director of cardiothoracic and vascular surgery at East Carolina University, wrote an accompanying editorial to the JAMA study. He believes the
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. FDA may speed review of new drugs
2. Scientists review SARS
3. US Reviews Risks Of Tamiflu After 12 Children Die
4. Breast Cancer Examinations To Be Reviewed In Irish Hospitals
5. BioCryst’s Bird Flu Drug Enjoys Fast-Track Review By FD
6. A Sneak Preview of Human’s Susceptibility to Auto Immune Disease, Allergy, Asthm
7. Thumbs up in weight loss for vegetarian diets: scientific review
8. FDA Accords Priority Review For Pediatric Crohns Disease Drug
9. The Lancet Calls For Review Of Regulatory Process Of Drug Trials
10. Review of Pramod Mahajans Injuries
11. Vaticans Council Reviews Condom Usage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... (PRWEB) November 26, 2014 Loffler Companies ... The Week in Imaging, an online information and news ... This is the sixth consecutive year Loffler has earned ... years. , The Elite Dealer Awards honor the best ... This year’s Elite Dealer honorees were chosen for their ...
(Date:11/26/2014)... Senior Planning Services, providing “expert guidance ... organization providing the adult demographic education and access ... navigate the rough seas of applying for Medicaid. Part ... the topic of Medicaid eligibility and proper planning, while ... applying for this coverage. , Senior Planning Services ...
(Date:11/26/2014)... NY (PRWEB) November 26, 2014 Call ... research requirements or email the details on sales(at)researchmoz(dot)us ... diabetes and drug discovery market 2014" with deep study ... is the result of high blood sugar. The global ... directly linked to the growing number of diabetics in ...
(Date:11/26/2014)... Rouge, Louisiana (PRWEB) November 26, 2014 ... neck pain relief and specialists in minimally invasive ... K. Samer Shamieh into the rapidly growing provider ... specialists. The addition coincides with the network’s ... reliable medical treatment for Louisiana residents who are ...
(Date:11/26/2014)... Youngsters who enter puberty early are at increased risk ... was linked with a number of factors associated with ... according to the researchers. Early puberty was also linked ... peers, and having friends who were prone to getting ... found an association between early puberty and these factors, ...
Breaking Medicine News(10 mins):Health News:Loffler Companies Recognized as an Elite Dealer for Sixth Consecutive Year 2Health News:Senior Planning Services Teams Up with SeniorNet To Educate Seniors On Medicaid Planning 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 3Health News:Louisiana Back Institute Welcomes Dr. K. Samer Shamieh into Medical Provider Network 2Health News:Early Puberty Linked to Increased Risk of Depression in Teens 2
... (BMC) New England Centenarian Study report that for ... age-related diseases (i.e. stroke, cardiovascular disease, diabetes) may ... the avoidance of disability may be a key ... in the February 11th issue of Archives of ...
... of the ovaries has been widely adopted as ... or BRCA2 mutations. A new multicenter study led ... is the first prospective examination of the impact ... were analyzed separately from BRCA1 mutation carriers. All ...
... 11 Team Health Inc.,s parent,company, Team Finance ... the fiscal year and the fourth quarter ended ... the decision to exit the anesthesia,management services business ... existing relationships within this operation and the final,phase ...
... today announced it has extended the enrollment deadline to,March ... medical plan. The new,plans will become effective on May ... can be difficult, and we,have heard retirees, requests for ... Secretary of Administration Naomi Wyatt said.,"Therefore, we are providing ...
... developed at MIT can deliver controlled drug doses to ... as a micro pharmacy. , The film could eventually ... and other diseases. It is among the first drug-delivery ... small electric field. , You can mete out what ...
... million, Five-year Grant, from New York State Department of,Health, ... Lead,Poisoned, NEW YORK, Feb. 11 The Lead ... Montefiore,(CHAM) has been named one of three State Regional ... healthcare delivery for children and,pregnant women with elevated blood ...
Cached Medicine News:Health News:Researchers at BMC find disability does not necessarily follow disease in living to old age 2Health News:Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations 2Health News:Team Finance LLC Announces Fiscal 2007 Results 2Health News:Team Finance LLC Announces Fiscal 2007 Results 3Health News:Team Finance LLC Announces Fiscal 2007 Results 4Health News:Team Finance LLC Announces Fiscal 2007 Results 5Health News:Team Finance LLC Announces Fiscal 2007 Results 6Health News:Team Finance LLC Announces Fiscal 2007 Results 7Health News:Team Finance LLC Announces Fiscal 2007 Results 8Health News:Team Finance LLC Announces Fiscal 2007 Results 9Health News:Team Finance LLC Announces Fiscal 2007 Results 10Health News:Office of Administration Extends Retired State Employees Health Benefits Enrollment Period to March 21 2Health News:MIT develops thin-film 'micro pharmacy' 2Health News:Montefiore Lead Poisoning Prevention ProgramNamed One of Three State Regional Resource Centers 2
(Date:11/26/2014)... EMERYVILLE, Calif. , Nov. 25, 2014 ... nanotechnology company focused on the development of ... more accurate testing in hospital and pre-hospital ... Standards Organization (ISO) 13485:2003 certification.  The certification ... (BSI), one of the world,s leading certification ...
(Date:11/26/2014)... , Nov. 25, 2014  Breckenridge Pharmaceutical, ... a multi-product ANDA agreement with Pii (Pharmaceutics International, ... under which Breckenridge and Pii expect to develop ... of the agreement, Pii will develop, manufacture and ... distribute the products under its own label.  The ...
(Date:11/26/2014)... Halozyme Therapeutics, Inc. (NASDAQ: HALO ) ... New York on Wednesday, December 3, ... Helen Torley , President and Chief Executive Officer, will ... webcast through the "Investors" section of Halozyme,s corporate website at ... for 90 days following the event. To access the live ...
Breaking Medicine Technology:Nanomix Receives ISO 13485:2003 Certification 2Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with Pharmaceutics International, Inc. 2Halozyme Therapeutics To Present At The Piper Jaffray Healthcare Conference 2
... Baxano, Inc. ( www.baxano.com ) today announced the closing ... funding, led by new investor CMEA Capital.   Funds were also ... and existing investors Prospect Venture Partners, Three Arch Partners, and Kearny ... , ...
... China , June 22 /PRNewswire-Asia-FirstCall/ -- ... "Company"), a,developer, manufacturer and distributor of botanical products,bio-pharmaceuticals ... Company plans to launch its new all-natural anti-depressant ... Tablets"), a,single plant based medicine, in July ...
Cached Medicine Technology:Baxano, Inc. Announces Close of $30 Million Series C Funding 2Renhuang to Launch New All-Natural Anti-depressant and Nerve Regulation Product - Compound Schisandra Tablets 2Renhuang to Launch New All-Natural Anti-depressant and Nerve Regulation Product - Compound Schisandra Tablets 3Renhuang to Launch New All-Natural Anti-depressant and Nerve Regulation Product - Compound Schisandra Tablets 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: