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FDA funds Rochester researchers to give chronic and acute pain clinical trials a makeover
Date:11/14/2011

nt it is to very carefully rate their pain on the standard 0-10 scale that is used in most studies another factor that may lead to the failure of a trial to distinguish between placebo and active therapy patients.

To examine these and many other questions, the team will scour FDA databases housing information from hundreds of pain clinical trials an invaluable resource not typically available to researchers. They will also analyze previously published pain clinical trials and data from studies sponsored by various pharmaceutical companies.

Beyond Dworkin and Turk, the initiative, known as ACTTION (Analgesic Clinical Trial Translations, Innovations, Opportunities, and Networks), involves the collaboration of public and private organizations, including professional societies, patient advocacy groups, industry, and government. It stems from a one-year, $1 million contract awarded to the group in 2010.

According to a report by the FDA, "Advancing Regulatory Science for the Public Health", the time for the research is right. "We are facing a global epidemic of prescription pain medicine abuse and misuse. At the same time, patients in agonizing pain are often left untreated. New pain pathways have been discovered and new medicines are being developed that can help. But to accelerate the delivery of new treatments to patients, we need to find better pain models, measurement tools (including patient-reported assessments) and clinical trial designs to enable development of effective medications with less potential for abuse."


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Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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