Navigation Links
FDA approves many drugs that predictably increase heart and stroke risk
Date:5/27/2014

The agency charged to protect patients from dangerous drug side effects needs to be far more vigilant when it comes to medications that affect blood pressure.

Robert P. Blankfield, MD, MS, a clinical professor of family medicine, issues this call to the U.S. Food and Drug Administration (FDA) in an editorial published recently in an online edition of the Journal of Cardiovascular Pharmacology and Therapeutics; the print version of the article is expected to appear this autumn.

The editorial notes that several medications survived FDA scrutiny, only to be pulled from the market after reports of increased heart attacks and strokes related to use of the drugs. These include rofecoxib (Vioxx), valdecoxib (Bextra), and sibutramine (Meridia). What these drugs have in common is that they raise blood pressure. Other medications approved by the FDA, including some antidepressant medications as well as medications used to treat attention deficit hyperactivity disorder, also raise blood pressure but remain on the market despite inadequate safety data.

At issue is the apparent disconnect between what patients and doctors might consider "clinically significant" risk and the standards that some FDA reviewers apply when evaluating the safety of new therapeutics. When it comes to medications that affect blood pressure, a few FDA reviewers only classify "clinically significant" blood pressure spikes as those that raise systolic blood pressure by 20 mm Hg (milliliters of mercury) or diastolic blood pressure by 10 to 15 mm Hg.

Increases in systolic blood pressure of more than 2 mm Hg or increases in diastolic blood pressure of more than 1 mm Hg raise the risk for heart attack by 10 percent and stroke by 7 percent in middle-aged adults, according to an epidemiological study published in Lancet in 2002. Younger individuals have less risk. For example, studies published in 2011 in the New England Journal of Medicine and the <
'/>"/>

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. FDA approves first targeted drug for advanced stomach cancer
2. Augusta Maine Chocoholic, Adam Green, Approves Xocai's "Change Your Chocolate" Success to Demand for Raw Blueberry in Nagoya, Japan and Taipei, Taiwan
3. German Research Foundation approves research unit to study extreme experiences in life
4. FDA Approves Memory Shape Silicone Implants
5. Branches' Ways to Work Program Approves 60th Car Loan
6. Breast Augmentation – FDA Approves New Silicone Gel Implant
7. AOAC International Approves ORAC as First Action Official Method
8. Texas House Approves Reverse Mortgage Legislation
9. FDA Approves New Drug to Fight Advanced Prostate Cancer
10. FDA Approves Morning-After Pill Without a Prescription
11. FDA Approves New “Gummy Bear” Breast Implants, But Albany Plastic Surgeon Urges Caution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... 2015 Hastings and Hastings, a law firm ... record number of legal representation client review requests for slip ... a steady rise in the number of slip and fall ... throughout the Valley. With that said, a large number of ... an experienced law firm. Hastings and Hastings is a personal ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 The City of ... at 10 a.m., to commemorate the 42nd anniversary of the Supreme ... States. , “It’s been 42 years since the Roe vs. Wade ... is still as present as ever,” said City of West Hollywood ...
(Date:1/22/2015)... 2015 The Incredible Bulk is a revolutionary ... increase lean muscle by up to 30lbs in less than ... of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... step-by-step, scientific diet formula that allows the body to pack ...
(Date:1/22/2015)... January 22, 2015 Juvent Sports ( ... the 2015 PGA Merchandise Show to bestow a Juvent ... female amateur golfer, Arlene McKitrick. The award commemorated and ... golf tournament win. She won her first amateur tournament ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Carinsurancesavings.biz has released ... accidental death and dismemberment insurance . , Purchasing an ... can be very advantageous. This type of rider provides benefits ... dismemberment can be considered a lesser form of life insurance. ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2
... to expand GSK cardiovascular portfolio in US Acquisition ... provides sales, synergy ... /PRNewswire-,FirstCall/ -- GlaxoSmithKline (LSE: GSK) (NYSE: GSK ) and ... which Reliant will be acquired by GSK for $1.65 billion ...
... Give More Than $7.2 Million and Volunteer, Thousands of ... the Country, ABBOTT PARK, Ill., Nov. 21 ... their neighbors, providing more than,$7.2 million in support for ... These employee contributions from the,company,s annual giving campaign are ...
... often deadly among older American women, doctors too often ... new report by a team of vascular surgeons from ... College campuses of NewYork-Presbyterian Hospital. , Much of that ... research has focused almost exclusively on males, so in ...
... Partnership to Create Enhanced, Customized Computer-Aided Detection ... Technology for GE ... 21 ,iCAD(R), Inc. (Nasdaq: ICAD ), an industry-leading ... division of,GE (NYSE: GE ), a manufacturer of ...
... a Web-based program that tracks pharmacy doses from order entry ... ... 21 Baxa Corporation has signed a,strategic reseller agreement with MedKeeper to ... sales and distribution rights for all worldwide healthcare,markets for the MedKeeper software., ...
... Nov. 21 /PRNewswire-FirstCall/ - Labopharm Inc. (TSX: DDS;,NASDAQ: ... written response from,the U.S. Food and Drug Administration ... for its once-daily tramadol formulation through,the Formal Dispute ... the Office of Drug Evaluation II, Center for ...
Cached Medicine News:Health News:GSK to Acquire Reliant Pharmaceuticals 2Health News:GSK to Acquire Reliant Pharmaceuticals 3Health News:GSK to Acquire Reliant Pharmaceuticals 4Health News:Abbott Employees Give Back to Local Communities This Holiday Season 2Health News:Abbott Employees Give Back to Local Communities This Holiday Season 3Health News:Arterial vascular disease underdiagnosed, undertreated in older US women 2Health News:Arterial vascular disease underdiagnosed, undertreated in older US women 3Health News:Arterial vascular disease underdiagnosed, undertreated in older US women 4Health News:GE Healthcare and iCAD enter into Developmental Agreement 2Health News:GE Healthcare and iCAD enter into Developmental Agreement 3Health News:GE Healthcare and iCAD enter into Developmental Agreement 4Health News:Baxa Corporation Signs Strategic Reseller Agreement With MedKeeper for Web-Based Productivity Tool 2Health News:Labopharm receives FDA response to appeal of Approvable Letter for once-daily tramadol 2
(Date:1/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/vzhr6h/video ) has ... Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - ... has been the topic of fascination since the era of ... and the Soviet Russia. Earlier even a small glimpse ...
(Date:1/23/2015)... BETHESDA, Md. , Jan. 23, 2015  Northwest Biotherapeutics, Inc. ... developing DCVax® personalized immune therapies for operable and inoperable solid ... will present at the 7 th Annual Phacilitate Immunotherapy ... NW Bio,s presentation at Phacilitate will take place on January ...
(Date:1/23/2015)... 23, 2015  Pete Rose, baseball,s all-time hits leader, is the ... reliever Myoflex, Ducere Pharma has announced. "Pete,s a ... to have him on board with Myoflex," said Ducere Pharma ... legendary player who is known across all generations. The passion ...
Breaking Medicine Technology:Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Pete Rose bets on Myoflex to relieve aches and pains 2
... 23 Anesiva, Inc. (Nasdaq: ANSV ) today announced that ... to join the Anesiva board of directors following completion of the ... is subject to a shareholder vote scheduled to take place at ... held on December 3, 2009 at 9:00 a.m. PST at 400 ...
... VIEJO, Calif., Nov. 23 Oceanside Pharmaceuticals, part of Valeant ... it has now launched chlordiazepoxide hydrochloride and clidinium bromide, an ... its first orders and expects to be a significant player ... has become an important division of our U.S. business with ...
Cached Medicine Technology:Anesiva Announces Prospective Board Members To Be Appointed Upon Successful Completion of Proposed Merger 2Anesiva Announces Prospective Board Members To Be Appointed Upon Successful Completion of Proposed Merger 3Anesiva Announces Prospective Board Members To Be Appointed Upon Successful Completion of Proposed Merger 4Oceanside Pharmaceuticals Announces Launch of Librax(R) AG 2
The DOT-approved A150 test is used for workplace testing, most publicly for federally mandated testing of transportation workers, but also in private company "drug free workplace" programs. Each hash...
... Our most popular onsite test! QuickScreen multi-panel ... urine sample, and your choice of any ... multi-panels offer total flexibility for your drug ... the specimen and the built-in timer tells ...
... Tests are available in 14 configurations including ... using Microgenics Antibody Technology, the SureStep™ MDMA ... care immunoassay targeted to detect MDMA that ... MDEA but no cross-reactivity to any isomer ...
... abuse tests are highly accurate in detecting the ... as confirmed by GC/MS testing. The assay provides ... method (such as GC/MS) must be used in ... should be applied to any drug of abuse ...
Medicine Products: