Navigation Links
FDA approves first human neural stem cell clinical trial to treat brain tumors
Date:6/8/2010

tumor-tropism of neural stem cells to deliver therapeutic agents to invasive tumor sites, which they demonstrated in laboratory testing. The therapy uses a genetically modified human neural stem cell line, generated by Seung U. Kim, M.D., Ph.D., professor in the Division of Neurology at the University of British Columbia, to deliver a prodrug-activating enzyme (cytosine deaminase) to brain tumor sites. This enzyme converts a relatively nontoxic prodrug (5-Fluorocytosine, 5-FC), which is delivered systemically, into an active cancer-fighting chemotherapeutic (5-Fluorouracil, 5-FU). In effect, this stem cell-mediated strategy achieves production of the chemotherapeutic drug only in the area of the tumor. This investigational treatment concentrates anticancer compounds at tumor sites while minimizing exposure of surrounding healthy tissue.

"This novel tumor-selective treatment has the potential to overcome many obstacles that limit the success of currently available treatments for malignant brain tumors and other invasive cancers," said Aboody. "Using neural stem cells as delivery vehicles for therapy may allow us to target concentrated therapeutics specifically to tumor sites while reducing the undesirable side effects of current chemotherapy regimens, including toxicity to normally dividing bone marrow, gastrointestinal tract, skin and hair cells."

The clinical trial will begin accepting patients this summer, with the goal of enrolling 12 to 20 patients with recurrent high-grade gliomas. The modified neural stem cells will be injected during surgery into the wall of the cavity remaining after tumor tissue has been removed. Study patients then receive daily doses of the prodrug 5-FC for one week. Based on Aboody's laboratory findings, once the 5-FC crosses the blood-brain barrier, the neural stem cells will convert the 5-FC to the active chemotherapy agent, 5-FU, at tumor sites in the brain. The phase I safety trial will assess the maximum tolerat
'/>"/>

Contact: Shawn Le
sle@coh.org
800-888-5323
City of Hope
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. FDA Approves First Additive Solution for Platelet Storage Up to 5 Days
2. State Approves Certificate of Need for New PeaceHealth San Juan Island Hospital
3. U.S. Approves New Stem Cell Lines for Publicly Funded Research
4. State Approves Plans For Kidney Transplants At Advocate Christ Medical Center
5. Medizone International, Inc. Approves Repurchase of Global Marketing Rights
6. A Christmas Gift for Eric: Senate Approves Health Care Bill in Historic Christmas Eve Vote
7. Kaiser Permanente Approves $170 Million in Community Benefit Grants in 2009
8. The American Association of Anatomists approves guidelines for body donation programs
9. Golden Meditech Shareholders Approves of Name Change
10. New Jersey Approves Initiative to Expand the Number of Wound Care Certified Professionals
11. Congress Approves Bill Curbing Internet Tobacco Sales in Victory for Kids and Taxpayers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... July 03, 2015 , ... B. E. Smith, the ... to lead a national president recruitment for Regional Care, Inc. in ... B. E. Smith has recently placed more than 1,000 healthcare executives into organizations. ...
(Date:7/3/2015)... (PRWEB) , ... July 03, 2015 , ... ... Lecture took place on June 25, 2015 at 1:00pm. The Association welcomed speaker ... issues pertaining to injured bicyclists and practical points of investigating these types of ...
(Date:7/3/2015)... ... , ... Talcum powder attorneys representing clients in national lawsuits announce the launch ... website. Just as the previous version did, the new website will serve as a ... ovarian cancer warning information. The site is routinely updated with news articles on talcum ...
(Date:7/3/2015)... ... July 03, 2015 , ... First Choice Emergency ... named Mariah N. Manzanares, MD as the new Medical Director of its Frisco facility. ... director of our Frisco facility,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:7/3/2015)... ... July 03, 2015 , ... Yisrayl Hawkins, Pastor and Overseer at ... that he says will reveal biblical truth and expose popular lies regarding proper relationships ... Say Don’t Have Sex”, immediately goes into the core of the subject by explaining ...
Breaking Medicine News(10 mins):Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3Health News:Attorney from William Mattar Leads Discussion on Bicycle Accidents 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 2Health News:Talcum Powder Lawsuit News: Cancer Attorneys Launch Updated Mobile Site 3Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 2Health News:First Choice Emergency Room Announces Dr. Mariah N. Manzanares as Medical Director of Frisco, TX Facility 3Health News:Yisrayl Hawkins Explains What the Bible Really Says about Sex in New Publication This Week 2
... number of sperm donors nationally, the Scottish IVF clinic at ... to its new patients//. ,Patient enrolled in the ... government has said patients treated halfway may need to register ... ,Sandra Kant, the clinic's spokeswoman says, it was ...
... Scots have a habit of enjoying the sun in its ... fact that in UK skin cancer figures are close to ... 7000 people annually contract a deadly malignant melanoma which results ... of sunscreen says cosmetic doctor Simon Connolly of Edinburgh's Mulberry ...
... Chennai-based Apollo Hospitals has registered the second highest success rate ... procedures done //by it are success stories, the group's chairman ... address at a Nurses Day celebration, he said while the ... for the surgery, Apollo was more cost effective as it ...
... A free glaucoma medical camp was organized by the Aravind ... ,According to a press release from the hospital, ... of diabetic, blood pressure and myopia patients contracting this disease. ... patients affected by this disease and complete vision can be ...
... in the USA and UK for hip resurfacing sugary has ... ,With the recent approval by Food and Drug ... becoming more and more popular Worldwide, Dr G Balasubramanian, a ... Hospital, told PTI here. ,However, the surgery was ...
... All over the world, when summer approach and the schools ... in mowing the lawn. For any reasons like either to ... the hands of dangerous condition, which needs more precaution. The ... below 19 years in an overall average of 230,500 people ...
Cached Medicine News:Health News:Lawn Mower injuries - children needs precaution 2
(Date:7/2/2015)... 2015  Before you head outdoors with your family to ... safe and healthy. Take steps to protect yourself from the ... Protect Your Skin From the Sun ... your risk of skin cancer. To protect your skin from ... especially during midday hours. Wear a hat with a wide ...
(Date:7/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/nlfg34/cancer ) has announced the addition of ... - Forecast to 2020" report to their offering. ... in 2020 from an estimated $7.1 Billion in 2015, growing at ... North America , followed by Europe ... World (RoW). The cancer diagnostics market in Asia ...
(Date:7/2/2015)... BURLINGTON, Mass. , July 2, 2015 /PRNewswire/ ... U.S. and European retinal specialists identify less frequent ... macular edema (DME), due to the burden on ... semi-monthly anti-vascular endothelial growth factor (VEGF) injections, which ... compound, Allergan/Molecular Partners, abicipar pegol, which is in ...
Breaking Medicine Technology:First Aid Summer Survival Tips from Nyack Hospital 2First Aid Summer Survival Tips from Nyack Hospital 3Global Cancer Diagnostics Market Report 2015 - Technology, Imaging and by Applications Forecasts to 2020 for the $13 Billion Industry 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 3
... MALVERN, Pa. , July 16 ... on ,Meaningful Use, of Electronic Health Records (EHRs) provides ... healthcare providers realize quality and efficiency gains through the ... criteria hospitals and eligible providers must meet through use ...
... POWAY, Calif. , July 15 NEXUS ... automated sample management systems, today announced the signing of ... of Tecan, as well as other related assets. Under ... REMP ® Sample Management business segment from Tecan.  REMP, ...
Cached Medicine Technology:Siemens Primed to Help Customers Achieve Newly-Defined Criteria for 'Meaningful Use' of an Electronic Health Record 2Siemens Primed to Help Customers Achieve Newly-Defined Criteria for 'Meaningful Use' of an Electronic Health Record 3NEXUS Biosystems Acquires Tecan Group's REMP Sample Management Business 2NEXUS Biosystems Acquires Tecan Group's REMP Sample Management Business 3NEXUS Biosystems Acquires Tecan Group's REMP Sample Management Business 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: