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FDA Updates Prescription Guidelines for Blood Thinner
Date:8/18/2007

Gene variations dictate how quickly a patient metabolizes warfarin, officials say

THURSDAY, Aug. 16 (HealthDay News) -- The U.S. Food and Drug Administration announced Thursday a labeling update for the widely prescribed blood thinner warfarin (Coumadin), advising doctors that patients' genetic makeup can affect how they respond to the drug.

Responses to warfarin depend on a patient's variants of the genes CYP2C9 and VKORC1. About 30 percent of patients -- many of them heart patients -- who take warfarin have these gene variants.

These variations can determine how fast warfarin is metabolized, Larry Lesko, director of the FDA's office of clinical pharmacology at the Center for Drug Evaluation and Research, said during a teleconference. "Patients with these variations may need lower doses of warfarin than patients with the usual forms of these genes.

"The label change explains that certain people are likely to respond very differently to the drug if they happen to carry variations of two of their genes," Lesko said. The label updates are based on recent studies that found patients' response to the drug depends on these gene variations, he added.

In the United States, some 2 million people start taking warfarin every year to prevent blood clots, heart attacks and stroke, according to the FDA. Warfarin is tricky to use, because the correct dose varies and depends on risk factors, including diet, age, and other medications the patient is taking.

If the warfarin dose is too high, there is the risk of life-threatening bleeding. If the dose is too low, there is a risk of developing blood clots. Dosing is particularly important when starting the drug, the FDA said.

The FDA isn't mandating that doctors obtain genetic tests before prescribing warfarin but suggests that it is something doctors may want to consider when prescribing the drug.

"Doctors and other health-care professio
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