Navigation Links
FDA Renews Heart-Risk Warning for Antibiotic
Date:3/12/2013

By Steven Reinberg
HealthDay Reporter

TUESDAY, March 12 (HealthDay News) -- U.S. health officials reiterated Tuesday that the widely prescribed antibiotic azithromycin (Zithromax, Zmax) may slightly raise the risk of death in patients with heart problems.

Specifically, the drug and others in its class called macrolides can cause abnormal changes in the electrical activity of the heart that may lead to a potentially fatal irregular heart rhythm, the U.S. Food and Drug Administration said.

Responding to the FDA warning, Dr. Gregg Fonarow, director of the Ahmanson-UCLA Cardiomyopathy Center, said, "It is important for doctors to be fully aware of the potential risk of fatal heart rhythms that can result from the administration of certain medications, particularly in patients with certain risk factors."

Those at highest risk for this problem are people with known risk factors, such as existing heart problems, particularly what is known as QT prolongation; low levels of potassium or magnesium; a slower than normal heartbeat; or taking certain drugs to treat abnormal heart rhythms, the FDA said.

The risks associated with azithromycin appear to be small in absolute terms, and other antibiotics also have the potential for QT prolongation and what's known as torsades de pointes, which is an abnormally fast heartbeat that can lead to cardiac arrest, Fonarow said.

The FDA's action is based on its review of a study published last May in the New England Journal of Medicine that found this problem with azithromycin. In that study, researchers calculated the absolute risk at 47 cardiovascular deaths for every 1 million prescriptions for azithromycin.

At that time, the FDA said patients taking the drug should be aware of the potential for heart problems. It also said it would review the study.

The agency's announcement Tuesday was also based on a study done by one maker of the drug that looked at the potential for irregular heart rhythms associated with azithromycin.

Based on these studies, the FDA said, the drug's label has been updated to strengthen the warning of heart problems in some patients. The agency is asking doctors to consider the potentially fatal heart rhythms when prescribing azithromycin, especially to high-risk patients.

Azithromycin isn't the only antibiotic linked to potentially fatal heart problems. Fluoroquinolones, which are a different type of antibiotics, also "have the potential for QT prolongation or other significant side effects that should be considered when choosing an antibacterial drug," the FDA said in a news release.

More information

For more on azithromycin, visit the U.S. National Library of Medicine.

SOURCES: Gregg Fonarow, M.D., director, Ahmanson-UCLA Cardiomyopathy Center and co-director of the UCLA Preventative Cardiology Program, University of California, Los Angeles; U.S. Food and Drug Administration, news release, March 12, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Marietta Dentist Kirk Kimmerling DDS Renews Pledge to Calvary Children’s Home
2. Northbound Treatment Services Renews Successful Holistic Approach
3. Federal government renews contract for collecting and maintaining national stem cell transplantation database
4. Law Firm Issues Biomet Hip Infographic Warning Consumers About the Dangers of Biomet Hip Implants
5. Specific warning signs of complications in colorectal surgical patients released
6. FDA Issues Another Warning on Fake Version of Cancer Drug Avastin
7. Graphic warnings on cigarettes effective across demographic groups
8. DrugRisk Announces New Pradaxa Health Warning From Australia
9. DrugRisk Adds Latest Health Warnings and Lawsuit Updates for Yaz
10. Fake Drugs Entering the U.S.: Lawyers at Console & Hollawell Highlight Federal Warnings About Counterfeit Medications
11. Warning Claim on Alleged Defective Wright Hip Implant Lawsuit Dismissed: AttorneyOne Informs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between ... they no longer use or need, from clothes to couches to dressers and bicycles. ... and take them to the nearest Goodwill donation center through February 28th. , ...
(Date:1/20/2017)... Miami, Florida (PRWEB) , ... January 20, 2017 , ... ... in head lice cases in families with school-aged children since the holiday season. ... spend the holidays with their families, sharing hugs and taking photos, which is the ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... its sugar-free alternative VW+ 002. The drinks have been produced in collaboration with ... to perform during your workout. , After a successful launch in Sweden last ...
(Date:1/20/2017)... ... 2017 , ... D R Burton Healthcare Products LLC, makers ... in a study indicating superior performance against competitive products in secretion clearance. ... Positive Expiratory Pressure Devices During Simulated Breathing“ was published in the winter issue ...
(Date:1/20/2017)... ... January 20, 2017 , ... “God's Miracle Man: Against All Odds”: an ... of published author, Keith C. A. Tucker, son of Minister Delores Pinnock and a ... by Reverend Mark Hardy , “While sitting up in bed, I felt a pounding ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 Shire plc (LSE: ... U.S. Food and Drug Administration (FDA) has acknowledged receipt ... Application (NDA) for SHP465, a long-acting, triple-bead, mixed amphetamine ... once-daily treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). The FDA is ... 20, 2017, the designated Prescription Drug User Fee Act ...
(Date:1/19/2017)... 19, 2017 Pfizer joins ... Milner Therapeutics Consortium   Major research ... Cambridge   The Milner Therapeutics ... ) as a partner to the Milner Therapeutics Consortium. ... the efficient transfer of materials between industry and academia ...
(Date:1/19/2017)... Florida , January 19, 2017 ... Trump administration appears serious about reducing the FDA,s ... and innovation in the medical drug industry, many ... ahead with new clinical trials and development of ... companies forging ahead with recent developments include:  Moleculin ...
Breaking Medicine Technology: