Navigation Links
FDA Gives Clinical Trial Green Light on Drug to Treat Alzheimer's Disease
Date:4/22/2009

Previous Studies Show Bryostatin Protects Against Alzheimer's Protein, Rewires and Repairs Brain Damage

MORGANTOWN, W.Va., April 22 /PRNewswire-USNewswire/ -- The Food and Drug Administration (FDA) has given the Blanchette Rockefeller Neurosciences Institute (BRNI) the go-ahead to conduct Phase II clinical trials of Bryostatin for the treatment of Alzheimer's disease patients. The drug showed pre-clinical efficacy to not only treat Alzheimer's disease symptoms, but also its underlying causes.

"We are very excited about the FDA's agreement for BRNI to move forward with clinical trials," said Dr. Daniel Alkon, Scientific Director of BRNI. "Bryostatin shows the promise to repair and protect against neurodegeneration caused by Alzheimer's disease, stroke and other brain trauma, as well as enhance the brain's normal memory functions."

Bryostatin was originally created as an anti-cancer chemotherapy. When BRNI scientists extensively tested PKC activators against Alzheimer's disease models, they discovered the drug's hidden potential to stop Alzheimer's disease. Over the past six years, the drug has shown remarkable possibilities. In preclinical testing, BRNI scientists experimented with Bryostatin on three species of Alzheimer's disease transgenic mice, each species based on different human Alzheimer's disease genes. The test results revealed that Bryostatin, and a related class of drugs discovered at BRNI, can reduce the toxic Alzheimer's disease protein A Beta, restore lost synapses, and protect against the loss of memory functions. In related preclinical testing, Bryostatin has been shown to enhance and restore memory by rewiring connections in the brain previously destroyed by stroke, head trauma, or aging itself.

The Phase II trials, slated to begin in approximately two to four months, will test these preclinical findings on human Alzheimer's disease patients as well as controls, along with
'/>"/>

SOURCE Blanchette Rockefeller Neurosciences Institute
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine news :

1. Health Care Policy Analyst Gives SALGBA Attendees a Glimpse of the Future
2. ScheduleAnywhere.com Gives Managers New Tools to Create Employee Schedules and Reduce Overtime
3. Nevada Breast Augmentation Surgeon Gives Reno Patients a Glimpse of Likely Results with Portrait 3D Computer Imagery
4. The Marcus Foundation Gives $20 Million to Grady Health System
5. New Program Gives Guardian Dental Pre-Paid/DHMO Members Greater Access to Specialty Care
6. Entertainment Fusion Group Gives Back
7. Rhode Island Cigarette Tax Increase Delivers Victory for Kids and Taxpayers; $1 Increase Gives State Highest Cigarette Tax in the Nation
8. American Heart Association Statement Gives Guidance on Minimally Invasive Procedures to Treat Diseased Brain Vessels
9. NASDAQ Gives Dynatronics a Third Three-Month Extension for Minimum Bid Price Compliance
10. New Mobile Patient Communicator(TM) Gives Patients an Interactive Education Tool and Boosts Nurse Productivity
11. Singapore Gives New Sight to the Blind
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... (PRWEB) December 17, 2014 Dr. Myo Nwe ... Weight Loss Diet of the Future” and co-founder of the ... her book, Dr. Nwe takes a broad look at the ... hold up under scientific scrutiny. On film and in television ... emphasized mostly toward the social aspects and played for basic ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 In its ... and its Argus Claim Review division have recently ... the most common ways savings are achieved on behalf ... attributes millions of dollars in savings to Argus each ... 2013. , As explained by Tom Doney, Cypress president ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. ... diseases, one worrisome phenomenon is when an illness that originated ... known as zoonosis -- is not uncommon and keeps researchers ... animal-borne disease might make inroads into the human population. ... and the culprits in this case were guinea pigs. More ...
(Date:12/17/2014)... Amy Norton HealthDay Reporter ... long been believed to improve overall health, but a growing ... the heart, a new review finds. In fact, the ... brisk walking, said lead researcher Paula Chu, a doctoral candidate ... review, of 37 clinical trials, found that people randomly assigned ...
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), Unionville’s first ... study providing evidence on the impact of 100% pure ... Sufficient enough evidence already exists showing a negative link ... with the onset of tooth decay. One question that ... 100% fruit juice, meaning it is completely natural with ...
Breaking Medicine News(10 mins):Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 3Health News:Yoga May Cut Heart Disease Risk Factors 2Health News:Yoga May Cut Heart Disease Risk Factors 3Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2
... NEW YORK, March 4, 2011 Despite significant investment in ... has seen a marked decline in the number of ... at the New York Academy of Sciences on Wednesday, ... experts in clinical, translational, and basic neuroscience to address ...
... By Ellin Holohan HealthDay Reporter , THURSDAY, ... chance of getting a kidney transplant than whites do, claims ... used to decide who gets which donated organs. The ... that once "waitlisted" for a needed kidney, white patients were ...
... - DNA provides the instruction manual for all life ... and bad messages are sent leading to the creation ... , Paul Doetsch, PhD, professor of radiation oncology and ... Winship Cancer Institute and Damien Brgeon, PhD, at Institut ...
... Dr. David Levin, Professor of Molecular & Cell ... Dental Medicine and Professor of Microbiology at Boston University ... mechanism for the regulation of gene expression. The study ... Paf1 Complex Blocks Sen1-Mediated Premature Transcription Termination," appears in ...
... on producing radiation inside a tumour using,boron-10 and thermal ... help of a special carrier substance (phenylalanine), after which ... react with the boron to generate high-LET radiation, which ... treatment sessions may be sufficient to destroy a tumour, ...
... Congress on Osteoporosis & Osteoarthritis - the most ... held in Valencia,s award-winning ,Palacio de Congresos, from ... to take advantage of lower registration fees. ... world,s top bone experts, Learn about key topics in ...
Cached Medicine News:Health News:White Patients Most Likely to Get Kidney Transplants: Study 2Health News:White Patients Most Likely to Get Kidney Transplants: Study 3Health News:Nature Reviews Cancer article traces possible role of damaged DNA in tumor development 2Health News:Novel mechanism for control of gene expression revealed 2Health News:BNCT, a new-generation radiation treatment, is effective in advanced head and neck cancer 2
(Date:12/15/2014)... BRIDGEWATER, N.J. , Dec. 15, 2014   ... SAN and NYSE: SNY) are collaborating with nationally-recognized patient ... Counts , an awareness program that will gauge how ... risks associated with high LDL-C (bad cholesterol).  American adults ... to take a brief poll and answer a few ...
(Date:12/15/2014)... --  DaVita HealthCare Partners Inc.  (NYSE: ... most innovative health care communities, today announced that ... Research  (DCR) and  HealthCare Partners Clinical Research , will ... research and data analytics services, specifically in patients ... disease (ESRD), as well as primary care and ...
(Date:12/13/2014)... December 12, 2014 ... the addition of the  "Global Catheters Market ... Global Trends, Company Profiles, Analysis, Segmentation and ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... up of medical grade material such as ...
Breaking Medicine Technology:Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4Global Catheters Market (Product Types and Geography) - Forecast to 2020 2Global Catheters Market (Product Types and Geography) - Forecast to 2020 3
... Uroplasty, Inc. (NASDAQ: UPI ), a medical device ... treat voiding dysfunctions, announced today that its President and CEO ... on Tuesday, June 7, 2011.  The ceremony, held at the ... be broadcast live beginning at 3:45 p.m. ET via the ...
... 6, 2011 University Hospitals (UH) Seidman Cancer ... hospital, opens to patients on June 6. The ... cancer-fighting treatments and technology – all in a ... ) The $260 million, 375,000-square-foot ...
Cached Medicine Technology:Uroplasty's Dave Kaysen to Ring NASDAQ Closing Bell 2University Hospitals Seidman Cancer Center Opens: First Cancer Hospital in Northeast Ohio Offers Nation's Most Advanced Technology and Treatments 2University Hospitals Seidman Cancer Center Opens: First Cancer Hospital in Northeast Ohio Offers Nation's Most Advanced Technology and Treatments 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: