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FDA Approves Symbyax(R) as First Medication for Treatment-Resistant Depression
Date:3/23/2009

e body temperature elevation, trouble swallowing and adverse events upon discontinuation of treatment.

The most common (> or = 5% and at least twice that for placebo) treatment-emergent adverse event associated with Symbyax in placebo-controlled clinical trials were weight gain, increased appetite, dry mouth, somnolence, fatigue, peripheral edema, tremor, sedation, hypersonmia, disturbance in attention, and blurred vision.

Full prescribing information, including boxed warnings, is available at www.symbyax.com, www.zyprexa.com and www.prozac.com.

About Lilly

Lilly, a leading innovation-driven corporation, is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers -- through medicines and information -- for some of the world's most urgent medical needs. Additional information about Lilly is available at www.lilly.com.

This press release contains forward-looking statements about Zyprexa, Prozac, and Symbyax. These statements reflect management's current beliefs; however, as with any pharmaceutical product there are risks and uncertainties in the process of research and development, regulatory review, and commercialization. In addition, there are no guarantees that the products will continue to be commercially successful or will be successful in these new indications. For further discussion of these and other risks and uncertainties, see Lilly's filings with the United States Securities and Exchange Commission. Lilly undertakes
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