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FDA Approves AstraZeneca's Seroquel(R) for Maintenance Treatment in Bipolar Disorder
Date:5/14/2008

r control, include, among other things, those risk factors identified in the Company's Annual Report/Form 20-F for 2007. Nothing contained herein should be construed as a profit forecast.

References:

1. SEROQUEL Prescribing Information. Available at

http://www1.astrazeneca-us.com/pi/seroquel.pdf. Accessed April 23,

2008.

2. Data on File, AstraZeneca LP, DA-SER-51.

3. Shastry, BS. Bipolar disorder: an update. Neurochemistry International.

2005; 46:273-279.

4. Hirschfeld RMA, Calabrese JR, Weissman MM, et al. Screening for Bipolar

in the Community. J Clin Psychiatry. 2003; 64:53-59.

5. U.S. Bureau of the Census -- 2005. Available at:

http://www.census.gov/popest/national/asrh/NC-EST2005/NC-EST200502.xls.

Accessed April 2, 2007.

6. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition,

Text Revision. Washington, DC: American Psychiatric Association; 2000:

382-392.

7. Vieta E, Eggens I, Persson I, et al. Efficacy and safety of quetiapine

in combination with lithium or divalproex as maintenance treatment for

bipolar I disorder [poster]. Presented at: The 20th European College of

Neuropsychopharmacology Congress; October 13-17, 2007; Vienna, Austria.

8. Suppes T, Liu S, Paulsson B, et al. Maintenance treatment in Bipolar I

disorder with quetiapine concomitant with lithium or divalproex: a

North American placebo-controlled, randomized multicenter trial

[poster]. Presented at the 46th Annual Meeting of the American College

of Neuropsychopharmacology; December 9-13, 2007; Boca Raton, FL, USA.

9. Brecher M, Liu S, Paulsson B. Quetiapine in the maintenance treatment

of bipolar I
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