Navigation Links
FDA Advisers Say Avastin Shouldn't Be Used for Breast Cancer
Date:7/21/2010

TUESDAY, July 20 (HealthDay News) -- The cancer drug Avastin should no longer be used as a treatment for breast cancer, a U.S. Food and Drug Administration advisory panel voted Tuesday, saying the drug wasn't benefiting patients.

The 12 to 1 vote represented a setback for Avastin, which is the world's best-selling cancer drug, with sales last year of about $6 billion. Avastin is sold by drug maker Roche's Genentech unit, The New York Times reported.

Earlier Tuesday, the advisory committee said data suggested that at least for breast cancer, the initial data that led to accelerated approval of Avastin in 2008 for breast cancer was not borne out by subsequent studies.

The drug is also approved for lung, colon, kidney and brain cancer, the Associated Press reported.

The 13 experts convened by the FDA voted unanimously that the drug's side effects and risks outweighed benefits when used with conventional chemotherapy.

When the FDA approved Avastin for breast cancer patients in 2008, it was on the condition that Roche provide additional studies supporting evidence that the drug kept the disease from worsening for more than five months.

But two follow-up studies failed to show that same effect, and patients did not gain any survival benefits. But they did experience serious side effects, including fatigue, abnormal white blood cell counts and high blood pressure, the AP reported.

"The study shows there's very little benefit to patients with significant toxicity risks and no clear survival benefit," said Natalie Compagni Portis, the FDA advisory panel's patient representative, the news service reported.

The FDA is not bound to follow the recommendations of its advisory committees, but typically does so.

More information

To learn more about Avastin, visit the U.S. National Library of Medicine.

-- HealthDay staff

SOURCES: U.S. Food and Drug Administration; The New York Times; Associated Press


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA to Broaden Disclosure on Advisers Conflicts of Interest
2. FDA Advisers Urge Stricter Regulation of Tanning Beds
3. Avastin Largely Safe for Patients With Type of Advanced Lung Cancer
4. Breast cancer cells regulate multiple genes in response to estrogen-like compounds
5. Susan G. Komen awards Case Western Reserve nearly $500,000 to study breast cancer in older women
6. Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer
7. Experts Issue New Guidelines on Breast Cancer Drugs
8. Radiation device allows for targeted breast radiation to control cancer
9. Scientists reprogram triple-negative breast cancer cells to respond to tamoxifen
10. Fish Oil Supplements Linked to Lower Risk of Breast Cancer: Study
11. Mathematical models for breast cancer detection with microwave tomography are cheaper and less risky
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... 2017 , ... Drs. Nicholas Rallis and Chris Chondrogiannis are ... years as clinical instructors for the reputable Full Mouth Rehabilitation continuing education (CE) ... private practitioners receive cutting-edge clinical training and learn how to perform full ...
(Date:5/24/2017)... OH (PRWEB) , ... May 24, 2017 , ... Patients ... in Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, with ... while simultaneously improving their oral health and functionality. , Dr. Bedich offers ...
(Date:5/24/2017)... ... 2017 , ... Myers Jackson is well known for auctioning homes that people ... anywhere on the planet. The luxury home market is alive and well and there ... quick search of “11 Spyglass Hill Auction will enlighten you on the dynamics of ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... female reproductive tract in which the endometrial lining of the uterus spreads ... and pain. Patients experiencing painful intercourse, painful periods, pelvic pain, or irregular ...
(Date:5/24/2017)... , ... May 24, 2017 , ... ... of ExtraHop to its solutions portfolio. ExtraHop delivers an analytics-first approach, layered with ... every IT system, from the datacenter to the cloud to the edge. Through ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)... 12, 2017  The China and Canada ... consumes less water, energy and detergent, and features a powerful disinfection ... a shoebox-sized washing machine that washes and sanitizes women,s panties or ... ... compact, and does not require an external water inlet. ...
(Date:5/10/2017)... , May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of ... is based on extensive data analysis from GHI,s hospitals ... hospitals database for the region. The GHI database covers 86% ... offering more than 130 data points for each institution in ...
(Date:5/10/2017)... , May 10, 2017 CSSi, the global ... the clinical research industry, is proud to announce the ... The new website features both enriched content and a ... and enhances the company,s already well-established position as the ... "After many months of hard work, we ...
Breaking Medicine Technology: