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Eye test peers into heat-related multiple sclerosis symptoms
Date:3/20/2008

n, included eight patients with MS who have INO, eight with MS but not INO, and eight healthy control subjects. Warm water in the body garment raised each subjects normal temperature by one-half of a degree Celsius, and the cool water brought it down by one-half of a degree.

The subjects also wore a lightweight device, fitted on a headband, that used infrared light to track their eye movements as they followed a random sequence of blinking lights.

In the subjects with INO, increasing the body temperature worsened the differences between their two eyes relative motion. Conversely, cooling the body made the eyes synchronize better.

Monitoring INO in a clinical setting could provide a sensitive test to determine a patients susceptibility to other heat-related MS symptoms, as well as a way to monitor the effectiveness of treatments, Dr. Frohman said.

With this new technique, we can objectively test new therapies that specifically treat a host of MS-related symptoms, said Dr. Frohman.

The next step in the research, Dr. Frohman said, is to use this system to measure the effectiveness of a drug that appears to relieve heat-induced symptoms in people with MS.

Weve shown that by this method we can model the principal mechanisms that cause certain symptoms to worsen in people with MS, he said.


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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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