Navigation Links
Eye-staining technique offers early detection for dry eye syndrome
Date:8/19/2007

DALLAS - Aug. 20, 2007 - Lissamine green sounds like the latest cleaning sensation being hawked on television and probably not something you would want to get in your eyes.

But a few properly placed drops can reveal staining patterns that are key to diagnosing dry eye syndrome earlier than other methods, providing doctors more options for treating the potentially sight-stealing disease, new research at UT Southwestern Medical Center confirms.

Lissamine green is an eye-drop stain used by ophthalmologists to detect damaged cells on the eyes surface, flagging them green under special lighting.

What this research showed is that the degree and pattern of staining was a good, objective indicator of the severity of the tear deficiency, said Dr. James McCulley, chairman of ophthalmology at UT Southwestern and one of the worlds leading experts on dry eyes.

Dry eye syndrome is one of the most common eye ailments. According to various estimates, it affects 10 percent to 30 percent of the worlds population, including 10 million to 14 million Americans mostly older women. Symptoms include eyes that burn or sting, blurred vision, frequent blinking, light sensitivity or a sandy or gritty feeling like something is in the eye.

In a study appearing in the July issue of the journal Eye and Contact Lens, Dr. McCulley and his colleagues found that the severity of the dry eye condition in patients correlates with where the stain patterns show up. Researchers identified three basic patterns that indicated progressively dangerous conditions:

  • The least-severe condition is indicated by stains limited to the whites of the eyes between the lids toward the nose. This so-called nasal staining doesnt necessarily predict dry eye: it might be caused by environmental factors, such as pollution.

  • The second level appears as stains in the white of the eye between the lids, but toward the ear. That is fairly diagnostic of a tear deficiency, Dr. McCulley said.

  • The third and most severe level occurs when the stain also appears on the cornea.

Thats when things really get serious, said Dr. McCulley, the studys senior author. If the dry eye is significantly affecting the cornea, it deteriorates vision and adds a major risk factor for a person developing a bad infection.

Stains in the cornea indicate a break in the surface cells. Most bacteria require such a break in order to penetrate the eye, where the bacteria can cause an ulcer.

When the surface is healthy, were protected against the vast majority of bacteria. But if theres a compromise of the surface, then bacteria can invade, said Dr. McCulley, who said the investigation was inspired by his many years observing staining patterns in the patients he treated.

Researchers examined the stain patterns in 22 patients with varying degrees of dry eyes and 11 patients without ocular disease, who served as control subjects. The research not only revealed the progressive pattern, but also underscored the value of using lissamine green stain over the more commonly used fluorescein stain, which doesnt easily identify damage until it is more progressed.

If an ophthalmologist uses the most commonly used stain, which is fluorescein, theyre going to miss the first two stages of the development of dry eye and consequently miss a lot of diagnoses, said Dr. McCulley, director of the Theodore and Mary Beasley Laboratory for Ocular Surface Research and the Jean H. & John T. Walter Jr. Center for Research in Age-Related Macular Degeneration.

Earlier diagnosis is crucial in giving doctors more treatment options and preventing the disease from getting worse. Dry eye syndrome can also signal other conditions such as lupus or rheumatoid arthritis, further underscoring the importance of early diagnosis.

The more severe stage is not only more problematic in affecting vision, but it is more difficult to treat and reverse, Dr. McCulley said. So its very important to diagnose at the mild stages because it can become a self perpetuating disease if not effectively treated.


'/>"/>

Contact: Russell Rian
Russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. PCR emerging as a promising technique for Diagnosing Urinary Tuberculosis
2. New Laser Techniques cure degeneration of the eye
3. Micro-camera provides new breast imaging technique
4. IVF technique May Increase The Risk Of Birth Defects
5. New Technique For Benign Breast Tumors
6. New technique to diagnose heart disease
7. Novel biopsy technique for prostate cancer
8. New technique for heart enlargement
9. Laser technique assists beard problem
10. Comparing Breast surgery techniques
11. Latest technique for asthma treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... AutismOne announced the ... Association of Integrative Medicine and available for application on Saturday, May 27, 2017, ... Conference in Colorado Springs. , Ed Arranga, president of AutismOne, stated: "Many of ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... Association’s Tri-State Camp Conference in Atlantic City March 13-16, was a busy spot ... team of professional staff discussed strategies for preventing outbreaks among camp communities during ...
(Date:3/28/2017)... ... ... Oily skin is a common and unwelcomed occurrence in people of all ages, genders and ... to the discussion of dealing with excess skin oil. “Oily skin is a challenge to ... can help remove the oily shine while keeping the skin fresh and clean,” says Dr. ...
(Date:3/28/2017)... ... 28, 2017 , ... “A Prophets Bones”: a thrilling adventure that reveals the mystery of Kevin’s ... things that his parents and teachers had asked of him that he had neglected to ... to defy the Almighty Creator. There were some who would have felt themselves to be ...
(Date:3/27/2017)... ... March 27, 2017 , ... The respected ... who want straight teeth without the extensive time commitment and aesthetic disadvantages of ... acquiring a referral. A custom-designed series of virtually invisible aligners are created for ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... Israel , March 27, 2017 ... oncology and immunology, announced today that AGI-134, an immunotherapy for ... acquisition of Agalimmune Ltd., will be featured at the upcoming ... in Washington, DC to be held ... ...
(Date:3/27/2017)... , March 27, 2017  BERG, a ... data-driven, biological research approach, today announced that ... the discovery of new data using a ... brown fat metabolism. Joslin Diabetes Center led ... Biology® platform for analysis of samples.  The ...
(Date:3/27/2017)... BOSTON , March 27, 2017  Allergan ... and Paratek Pharmaceuticals, Inc. (Nasdaq: PRTK), a biopharmaceutical ... innovative therapies based upon tetracycline chemistry, announced that ... the treatment of moderate to severe acne met ... a once-daily, oral, narrow spectrum tetracycline-derived antibiotic with ...
Breaking Medicine Technology: