Navigation Links
Eye Cell Implants Improve Parkinson's Symptoms
Date:4/28/2008

Small study found measurable gains in those with moderate to severe disease

MONDAY, April 28 (HealthDay News) -- By implanting specialized cells found in the human eye into areas of the brain damaged by Parkinson's disease, researchers were able to reduce symptoms and improve quality of life in people with moderate to severe Parkinson's.

The new treatment, dubbed Spheramine, reduced symptoms experienced when people were off their Parkinson's medications by 44 percent for as long as four years of follow-up. Quality-of-life measurements were up about 23 percent, according to the study, expected to be presented April 29 at the American Association of Neurological Surgeons' annual meeting, in Chicago.

"This is a promising study on a form of therapy that is different from anything out there," said the study's lead author, Dr. Roy Bakay, a professor of neurological surgery and the A. Watson and Sarah Armour Presidential Chair at Rush University Medical Center in Chicago.

"This therapy may be beneficial in itself, or it may be used as additional therapy," added Bakay, who was at Emory University in Atlanta at the time of the study.

Spheramine is made from cells called human retinal pigment epithelial cells (hRPE) that are found naturally in the human eye. By combining these cells with microscopic gelatin beads called microcarrier support matrix (MSM), the Emory researchers were able to produce Spheramine, a targeted therapy for Parkinson's. Spheramine can be implanted in the brain, where the eye cells naturally begin to produce levodopa. The researchers believe the levodopa is then turned into dopamine, a neurotransmitter lacking in people with Parkinson's.

"Spheramine is not stem cells. There's no requirement for immunosuppression, and these cells are easily harvested from eye banks and are readily available," Bakay said.

The new study included six patients with moderate to severe Parkinson's disease, a progressive brain disorder that causes tremors and other motor difficulties that worsen as the disease advances. Parkinson's affects as many 1.5 million Americans, according to background information in the study.

There are few effective treatments for Parkinson's, and those that do work often have unpleasant side effects and may stop working over time.

Patients selected for the study were chosen based on their responsiveness to levodopa and the severity of their symptoms when they were off their medication. Using MRI-guided stereotactic surgery, the researchers implanted Spheramine into areas of the volunteers' brains that appeared to be most affected by Parkinson's.

After 12 months, there was a 48 percent improvement in symptoms. At 48 months, that number had dropped to 44 percent, but Bakay said the researchers were pleased that the treatment maintained effectiveness for that long.

The only significant side effect seen in this small study was a transient headache, he said.

Dr. Bruce Silverman, a neurologist at Providence Hospital and Medical Center in Southfield, Mich., said the new study "showed that there was clinical improvement over a sustained period of time. The study was based on small numbers, but it shows some promise."

He added that the study needs to replicated with a larger group of patients.

Bakay said the researchers have recently completed a larger, double-blind study, and results of that trial should be available by the end of this year or early 2009.

More information

To learn more about treatments available for Parkinson's disease, visit the National Parkinson Foundation.



SOURCES: Roy Bakay, M.D., professor, neurological surgery, and the A. Watson and Sarah Armour Presidential Chair, Rush University Medical Center, Chicago; Bruce Silverman, D.O., neurologist, Providence Hospital and Medical Center, Southfield, Mich.; April 29, 2008, presentation, American Association of Neurological Surgeons' annual meeting, Chicago


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Physicians Anticipate Changes in Their Usage of Hip Implants
2. UT Southwestern testing new hybrid hearing device combining advantages of hearing aids, implants
3. Boston Scientific Announces First European Implants of New Devices to Treat Heart Failure and Sudden Cardiac Death
4. Small-Diameter Dental Implants Increasingly Popular In the US
5. Porous structures help boost integration of host tissue with implants, study finds
6. Implants Double Infection Risk After Breast Reconstruction
7. Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors
8. Freeze-dried tendon implants prove effective in early studies
9. ASPS Studies Re-Evaluate Psychological Benefits and Health Concerns of Silicone Breast Implants
10. Neural Insights Could Bring Better Cochlear Implants
11. Advertisements for Medical Devices, Implants Should Carry Warnings of Dangerous Side Effects, Infections
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Eye Cell Implants Improve Parkinson's Symptoms
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
Breaking Medicine Technology: