Navigation Links
Extracts of catfish caught in polluted waters cause breast cancer cells to multiply
Date:11/7/2007

WASHINGTON, D.C., Nov. 7 Exposing estrogen-sensitive breast cancer cells to extracts of channel catfish caught in areas with heavy sewer and industrial waste causes the cells to multiply, according to a University of Pittsburgh study being presented at the annual meeting of the American Public Health Association in Washington, D.C. The abstract, number 159141, will be presented at a special session on Contaminants in Freshwater Fish: Toxicity, Sources and Risk Communication, at 8:30 a.m., Wednesday, Nov. 7.

The study, which tested extracts from channel catfish caught in the Allegheny and Monongahela rivers near Pittsburgh, suggests that the fish, caught in areas of dense sewer overflows, contain substances that mimic the actions of estrogen, the female hormone. Since fish are sentinels of water quality, as the canary in the coal mine is a sentinel of air pollution, and can concentrate fat soluble chemicals from their habitats within their bodies, these results suggest that pharmaceutical estrogens and xeno-estrogenic chemicals, those that mimic estrogens in the body, may be making their way into the regions waterways.

We believe there are vast quantities of pharmaceutical and xeno-estrogenic waste in outflows from sewage treatment plants and from sewer overflows, and that these chemicals end up concentrated and magnified in channel catfish from contaminated areas, said Conrad D. Volz, Dr.P.H., M.P.H., principal investigator, department of environmental and occupational health, University of Pittsburgh Graduate School of Public Health. Sewer overflows result from inadequate sewer infrastructure, which releases raw, untreated sewage directly into area rivers during wet weather, according to Dr. Volz. In Pittsburgh alone, 16 billion gallons of raw, untreated sewage are deposited into area rivers every year with major implications for public health.

In the study, Dr. Volz and colleagues exposed extracts of catfish to estrogen-responsive and estrogen non-responsive human breast cancer cells. They found that catfish extracts caused the estrogen-responsive breast cancer cells to multiply by binding to and activating estrogen receptors the proteins within cells that render the cells sensitive to estrogen but had no effect on the estrogen negative cell line. Extracts of fish caught in areas heavily polluted by industrial and municipal wastes resulted in the greatest amount of cell growth. This growth occurred regardless of the sex of the fish.

According to Dr. Volz, the next step in this research is to identify the specific estrogenic chemicals and their sources in the local water and fish. These findings have significant public health implications, since we drink water from the rivers where the fish were caught. Additionally, the consumption of river-caught fish, especially by semi-subsistence anglers, may increase their risks for endocrine-related health issues and developmental problems, said Dr. Volz.


'/>"/>

Contact: Clare Collins
CollCX@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related medicine news :

1. Higher levels of pollutants found in fish caught near a coal-fired power plant
2. Out of the woods: Physicians get urban disaster training in forests, gorges and waters
3. Waters Corporation Receives Market Leadership and Product Innovation Awards
4. Drug for cluster headaches may cause heart problems
5. Study Points to Cause of Vioxx Heart Risk
6. Damp, Moldy Homes May Cause Depression
7. Constipations Many Causes and Cures
8. High Co-Pays Cause Seniors to Go Without Meds
9. 13 percent of women stop taking breast cancer drug because of side effects, U-M study finds
10. Vocal cord dysfunction may be caused by work
11. Study finds drug spending caps cause some seniors to quit taking key medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Pekin, IL (PRWEB) , ... October 13, 2017 ... ... Foundation, which established the certification process to promote standards of excellence for the ... iaedp™ Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at ...
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
(Date:9/25/2017)... 25, 2017  EpiVax, Inc., a leader in ... immune-engineering today announced the launch of EpiVax Oncology ... personalized therapeutic cancer vaccines. EpiVax has provided $500,000 ... to enabling technologies to the new precision immunotherapy ... EpiVax Oncology as Chief Executive Officer. Gad brings ...
Breaking Medicine Technology: