Navigation Links
Extracellular protein sensitizes ovarian cancer cells to chemotherapy
Date:12/10/2007

Scientists have uncovered critical new details about the mechanisms that modulate the response of ovarian cancer cells to chemotherapy. The research, published by Cell Press in the December issue of Cancer Cell, helps to explain why many patients develop resistance to the taxane class of drugs and may lead to improved treatment of ovarian cancer.

Cancer cells divide rapidly and undergo extensive microtubule-driven restructuring as they proliferate. Taxanes, such as paclitaxel (Taxol), interfere with the dynamic growth of microtubules by directly binding to them and making them more stable and, as a result, disrupt the normal process of cell division. Paclitaxel has been used extensively to treat lung, ovarian and breast cancers but drug resistance limits the clinical usefulness of this drug to only about half of breast or ovarian cancer patients.

Although it is clear that taxane resistance is associated with a loss of stable microtubules and that microtubule stability can be influenced by signals from the extracellular matrix (ECM), a role for ECM proteins in the modulation of paclitaxel sensitivity has not been established. To explore the connection between regulation of microtubules and taxane resistance, Dr. James D. Brenton from the Cancer Research UK Cambridge Research Institute in Cambridge, England and colleagues performed an extensive examination of ovarian cancer cell lines that were sensitive or resistant to paclitaxel.

The researchers found that the ECM protein, transforming growth factor beta induced (TGFBI), was significantly reduced in paclitaxel-resistant cells. Importantly, TGFBI mediated sensitization to paclitaxel and loss of TGFBI was sufficient to induce paclitaxel resistance. TGFBI induced microtubule stabilization that was dependent on integrin-mediated FAK and Rho signaling. Further, analysis of ovarian cancer samples taken after treatment with paclitaxel revealed that paclitaxel-induced cell death was associat
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... "When men sit down to use the toilet, ... water inside the bowl, the interior rim of the ... inventors from Naugatuck, and Bridgeport, Conn. "In order to ... , They developed the IPSAFE to prevent the penis ... and seat. This minimizes exposure to germs, which helps ...
(Date:8/23/2014)... York, New York (PRWEB) August 23, 2014 ... http://www.consumerinjurylawyers.com/wright-conserve-hip-replacement.html ) filed on behalf of individuals ... the Conserve hip replacement line continue to move ... of Georgia, Bernstein Liebhard LLP reports. According to ... established a bellwether trial program that would allow ...
(Date:8/23/2014)... 23, 2014 On Monday, August 18th, ... data breach suffered by Community Health Systems, which ... of 4.5 million records containing Personally Identifiable Information (PII) ... to Mandiant, who was engaged to investigate the incident, ... advanced group of cyber attackers based in China, who ...
(Date:8/23/2014)... The MPWMD Board of Directors voted on ... a sole source of water for commercial and industrial properties. ... Ron Brown of Archworks, LLC in Carmel, California. , ... time a water district in the State of California has ... AWGs at this time can now be used as ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 Pixel Film Studios, ... announced today the release of ProIntro Vol.3, a customizable ... fresh and professional tile just by dragging ProIntro Vol.3 in ... "ProIntro Vol.3 is a definite time saver and i think ... pack with 30 beautifully designed titles made with Final Cut ...
Breaking Medicine News(10 mins):Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 2Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 3Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 4Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 2Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 3Health News:This Time Prominent Hospital Group Falls Prey to Hackers Believed to be Based in China 4Health News:Historical Moment in the Monterey Peninsula, Brings Drought Relief Solution to California, with the Help of EcoloBlue and AWG Technology 2Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2
... blue lights, are usually most useful on the top of ... Warwick has found a way to use blue light to ... Research led by the University of Warwick, along with ... have found a new light-activated platinum-based compound that is ...
... A new National Research Council report finds no ... through the government,s ground beef purchase program and distributed ... the National School Lunch Program -- would lead to ... Agriculture,s Agricultural Marketing Service (AMS) buys ground beef from ...
... Ind. -- A new study by sexual health researchers ... during sex reported significantly higher levels of satisfaction and ... largest systematic study of this kind, despite the widespread ... concerning its role in alleviating pain or contributing to ...
... 8, 2010) A school-based intervention program helped New ... asthma better manage their symptoms, dramatically reducing the need ... according to a study published online in the ... Students in the eight-week program reported a ...
... Reporter , WEDNESDAY, Dec 8 (HealthDay News) -- A ... pet craves. Over the past five years, sugar has ... cat treats to make them more palatable and profitable, according ... Pet Obesity Prevention. Noting that 90 million U.S. pets ...
... WEDNESDAY, Dec. 8 (HealthDay News) -- If you have ... their accent may help you understand what they,re saying, ... on how well they understood sentences spoken in an ... participants were given different instructions on how to respond ...
Cached Medicine News:Health News:Platinum and blue light combine to combat cancer 2Health News:Stricter testing for federal ground beef program may not lead to safer meat 2Health News:Stricter testing for federal ground beef program may not lead to safer meat 3Health News:Study examines effect of water-based and silicon-based lubricant 2Health News:Study examines effect of water-based and silicon-based lubricant 3Health News:School-based program effective in helping adolescents 2Health News:Those Sweet Pet Treats May Foster Fatness 2Health News:Those Sweet Pet Treats May Foster Fatness 3
(Date:8/21/2014)... 21, 2014 The spinal column is one of ... Signals carried to and from the brain through the column ... system. Injury or ailment here can be life altering, and ... of control over their body. Though back injury and disease ... there are more options available to make things better than ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources ...  physicians in Brazil and ... clinical guidelines and commonly prescribe long-acting beta-agonist (LABA)- ... they do so within current severe cost/coverage constraints. ... that are expected to launch in these countries—which ...
(Date:8/21/2014)... , Aug. 21, 2014  Seventy-one percent of Americans believe ... is a serious public health and safety issue in ... a survey released today by Repass & Partners, a ... "Americans understand the severity of the prescription medication abuse ... with this very serious health situation facing our country," ...
Breaking Medicine Technology:Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... Reportlinker.com announces that a new market research ... Insulin Patch Pumps ... inhaled insulin market in 2008 has resulted in ... now appears that the patch pump – a ...
... Reportlinker.com announces that a new market ... The Outlook for Pharmaceuticals ... http://www.reportlinker.com/p0203102/The-Outlook-for-Pharmaceuticals-in-Central-Asia.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory These reports provide ... most populous countries in the world and ...
Cached Medicine Technology:Insulin Patch Pumps 2The Outlook for Pharmaceuticals in Central Asia 2The Outlook for Pharmaceuticals in Central Asia 3The Outlook for Pharmaceuticals in Central Asia 4
... of Topics Covered: diagrams, full ... and differentials of a multitude ... vision loss, pupillary abnormalities, glaucoma, ... medications, cataracts, vision correction surgery, ...
... all those involved with healthcare decisions to ... latest evidence in their field of interest ... year as the volume of evidence increases. ... the best single source available for continually ...
Muscles Anatomy Flash Cards uses the time tested content and images from BryanEdwards.com....
The ideal on-the-spot reference for residents and practitioners seeking fast facts on fracture management....
Medicine Products: