Navigation Links
Extra Doses of Vitamins C, E Don't Guard Against Preeclampsia

Study adds to evidence that supplementation during pregnancy makes little difference

FRIDAY, Nov. 30 (HealthDay News) -- Taking extra doses of vitamins E and C doesn't reduce the chances of the blood pressure disorder preeclampsia in women who are at risk for the dangerous pregnancy complication, a new report finds.

The study casts real doubt on the effectiveness of this regimen in preventing preeclampsia, said study author Dr. Joseph A. Spinnato II, a professor of obstetrics and gynecology at the University of Cincinnati College of Medicine. "There were those that were arguing that the evidence was enough prior to our publication, so I think this is added weight," he said.

There may be other avenues of hope, however.

"The article was compelling and a little disappointing, but the authors left us with an out at the end of the article, that perhaps we shouldn't give E and C at the same time because the E might negate the C," said Dr. Miriam Greene, an assistant professor of obstetrics and gynecology at New York University School of Medicine in New York City. "You can continue and try to do the two separately. They did prove that the drugs were safe."

The findings appears in the December issue of Obstetrics & Gynecology.

Preeclampsia, which occurs in about 5 percent of all pregnant women in the United States, can lead to sudden high blood pressure and irregular blood flow. This can activate platelets and the clotting system, which in turn slows blood flow further.

Risk factors for preeclampsia include: first pregnancy, 10 years since previous pregnancy, carrying multiple fetuses, being overweight, being under 20 or over 35, or having a history of high blood pressure, diabetes, kidney disease, lupus or preeclampsia in a previous pregnancy, according to the March of Dimes.

At present, medical professionals have no clear guidance on how to prevent this potentially fatal condition.

"We don't have a good way to reduce the incidence of preeclampsia, except in calcium-deficient populations and those tend not to be in the U.S.," Spinnato said. "There is some evidence that still supports the use of baby aspirin among patients at risk, but even that is argued pretty heavily."

An Australian study published last year also found no benefit to vitamin C and E supplementation.

The current study involved 707 women at four Brazilian sites who were in their second trimester of pregnancy and who had chronic hypertension or a prior history of preeclampsia.

The women were randomly assigned to receive 1,000 milligrams of vitamin C with 400 International Units of vitamin E or a placebo daily.

The rate of preeclampsia was 13.8 percent in the vitamin group and 15.6 percent in placebo group, which was not a statistically significant difference.

There appeared to be no harmful effects on the fetus, a finding echoed in previous trials.

But this study had one surprise finding: more frequent premature rupture of membranes among women taking vitamins. "That was completely unexpected," said Spinnato, who is following up on the finding.

Other than the possibility that vitamin E is canceling out vitamin C, there is no clear explanation for why the combination didn't work.

"One of the continuing challenges to vitamin supplementation as a general thing is getting it from leafy vegetables is different than getting it from a pill," Spinnato said. "There are also those who argue that we didn't start [giving the vitamins] early enough, but that argument is difficult to swallow. There are medical and legal ramifications even for vitamins."

More information

To learn more about preeclampsia, visit the March of Dimes.

SOURCES: Joseph A. Spinnato II, M.D., professor, obstetrics and gynecology, University of Cincinnati College of Medicine; Miriam Greene, M.D., assistant professor, obstetrics and gynecology, New York University School of Medicine, New York City; December 2007 Obstetrics & Gynecology

Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New study: Pine bark extract reduces ADHD symptoms in children
2. IMA South American Extravaganza Dinner to Honor Coachella Valley Doctor
3. MassMutual Agent Honored by Insurance Industry for Extraordinary Service to Client
4. Wrigleys Orbit(R), Extra(R) and Eclipse(R) Sugar-Free Chewing Gums Awarded American Dental Associations Seal of Acceptance
5. NBME Appeals Massachusetts Judges Reversal of Lower Court in Suit for Extra Break Time During Medical Licensing Exam
6. Missouri House Recognizes Extraordinary Efforts Supporting National Guard Families
7. Portal vein thrombosis is common in extraportal vein obstruction
8. New study: pine bark extract boosts nitric oxide production
9. Markel Expands Classes for Contagion Risk with OUTBREAK(R) Extra Expense Coverage
10. Broccoli sprout-derived extract protects against ultraviolet radiation
11. Extracts of catfish caught in polluted waters cause breast cancer cells to multiply
Post Your Comments:
Related Image:
Extra Doses of Vitamins C, E Don't Guard Against Preeclampsia
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes ... of the facility as part of a disaster drill on October 3rd. , Apple ... Shelton City Emergency Manager, as well as the Connecticut Long Term Care Mutual ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... Milford, NJ (PRWEB) , ... October 13, 2017 , ... ... weekend at scenic Alexandria Park in Milford, NJ. This free event, sponsored by ... and physical activity. The fun run is geared towards children of all ages; ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a missionary ... Journey: From the Mountains to the Mission Field” is the creation of published author, ... ages and currently teaches a class of ladies at her church, which she has ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/27/2017)... YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a ... today announced that its MyDario product is expected to appear on The ... when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, The Dr. Oz ... The ...
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
Breaking Medicine Technology: