Navigation Links
Extra Doses of Vitamins C, E Don't Guard Against Preeclampsia
Date:11/30/2007

Study adds to evidence that supplementation during pregnancy makes little difference

FRIDAY, Nov. 30 (HealthDay News) -- Taking extra doses of vitamins E and C doesn't reduce the chances of the blood pressure disorder preeclampsia in women who are at risk for the dangerous pregnancy complication, a new report finds.

The study casts real doubt on the effectiveness of this regimen in preventing preeclampsia, said study author Dr. Joseph A. Spinnato II, a professor of obstetrics and gynecology at the University of Cincinnati College of Medicine. "There were those that were arguing that the evidence was enough prior to our publication, so I think this is added weight," he said.

There may be other avenues of hope, however.

"The article was compelling and a little disappointing, but the authors left us with an out at the end of the article, that perhaps we shouldn't give E and C at the same time because the E might negate the C," said Dr. Miriam Greene, an assistant professor of obstetrics and gynecology at New York University School of Medicine in New York City. "You can continue and try to do the two separately. They did prove that the drugs were safe."

The findings appears in the December issue of Obstetrics & Gynecology.

Preeclampsia, which occurs in about 5 percent of all pregnant women in the United States, can lead to sudden high blood pressure and irregular blood flow. This can activate platelets and the clotting system, which in turn slows blood flow further.

Risk factors for preeclampsia include: first pregnancy, 10 years since previous pregnancy, carrying multiple fetuses, being overweight, being under 20 or over 35, or having a history of high blood pressure, diabetes, kidney disease, lupus or preeclampsia in a previous pregnancy, according to the March of Dimes.

At present, medical professionals have no clear guidance on how to prevent this potentially fatal condition.

"We don't have a good way to reduce the incidence of preeclampsia, except in calcium-deficient populations and those tend not to be in the U.S.," Spinnato said. "There is some evidence that still supports the use of baby aspirin among patients at risk, but even that is argued pretty heavily."

An Australian study published last year also found no benefit to vitamin C and E supplementation.

The current study involved 707 women at four Brazilian sites who were in their second trimester of pregnancy and who had chronic hypertension or a prior history of preeclampsia.

The women were randomly assigned to receive 1,000 milligrams of vitamin C with 400 International Units of vitamin E or a placebo daily.

The rate of preeclampsia was 13.8 percent in the vitamin group and 15.6 percent in placebo group, which was not a statistically significant difference.

There appeared to be no harmful effects on the fetus, a finding echoed in previous trials.

But this study had one surprise finding: more frequent premature rupture of membranes among women taking vitamins. "That was completely unexpected," said Spinnato, who is following up on the finding.

Other than the possibility that vitamin E is canceling out vitamin C, there is no clear explanation for why the combination didn't work.

"One of the continuing challenges to vitamin supplementation as a general thing is getting it from leafy vegetables is different than getting it from a pill," Spinnato said. "There are also those who argue that we didn't start [giving the vitamins] early enough, but that argument is difficult to swallow. There are medical and legal ramifications even for vitamins."

More information

To learn more about preeclampsia, visit the March of Dimes.



SOURCES: Joseph A. Spinnato II, M.D., professor, obstetrics and gynecology, University of Cincinnati College of Medicine; Miriam Greene, M.D., assistant professor, obstetrics and gynecology, New York University School of Medicine, New York City; December 2007 Obstetrics & Gynecology


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New study: Pine bark extract reduces ADHD symptoms in children
2. IMA South American Extravaganza Dinner to Honor Coachella Valley Doctor
3. MassMutual Agent Honored by Insurance Industry for Extraordinary Service to Client
4. Wrigleys Orbit(R), Extra(R) and Eclipse(R) Sugar-Free Chewing Gums Awarded American Dental Associations Seal of Acceptance
5. NBME Appeals Massachusetts Judges Reversal of Lower Court in Suit for Extra Break Time During Medical Licensing Exam
6. Missouri House Recognizes Extraordinary Efforts Supporting National Guard Families
7. Portal vein thrombosis is common in extraportal vein obstruction
8. New study: pine bark extract boosts nitric oxide production
9. Markel Expands Classes for Contagion Risk with OUTBREAK(R) Extra Expense Coverage
10. Broccoli sprout-derived extract protects against ultraviolet radiation
11. Extracts of catfish caught in polluted waters cause breast cancer cells to multiply
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Extra Doses of Vitamins C, E Don't Guard Against Preeclampsia
(Date:2/24/2017)... , ... February 24, 2017 , ... ... on tooth replacement options at his office, Antoine Dental Center. Currently, patients can ... $18,499. Some restrictions may apply, but patients can learn more about these offers ...
(Date:2/24/2017)... ... February 24, 2017 , ... The Smart Machine Age ... Oxford University predict that 47 percent of all jobs in the United States may ... and “successful.” The day of the aggressive know-it-all who steamrolls over colleagues is drawing ...
(Date:2/24/2017)... ... , ... With ProGlass Prism users now have the ability to simulate prism ... position, rotation, distortion, edge softness, edge blur, chromatic aberration, individual glass position offset, anchor ... Prism users are given the tools and effects to generate a fractal prismatic ...
(Date:2/24/2017)... , ... February 24, 2017 , ... The Radiology ... excellence in radiology marketing programs at the annual Building Better Radiology Marketing Programs ... Fort Worth Hotel in Fort Worth, Texas. Nine awards are given out in five ...
(Date:2/23/2017)... ... February 23, 2017 , ... On February 22, 2017 the ... to withdraw previous guidance issued by the Obama Administration requiring schools to ... May 2016 by the Obama Administration came in response to a growing number ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Australie, le 24 février 2017 ITL Limited, ... santé diversifiée innovante, est ravie d,annoncer les excellents résultats ... la période précédente correspondante. Une présentation complète « Résultats et ... être consultée ici . Faits ... de 2,12 millions $ (Déc. 2015 : 1,04 million $ ; en hausse de ...
(Date:2/24/2017)... YORK , Feb. 23, 2017  The ... 330.6 million by 2021 from USD 275.9 million ... Read the full report: http://www.reportlinker.com/p04718602-summary/view-report.html ... increasing spending on pharmaceutical R&D, and growth in ... driving the market growth for particle counters. On ...
(Date:2/23/2017)... BOSTON , Feb. 23, 2017 ... devices and services since 1997, is changing the ... modern technology providing patients with pro-active, custom-made solutions. ... desire for instant and affordable healthcare without walls, ... of high-level devices developed with healthcare professionals that ...
Breaking Medicine Technology: