Navigation Links
External beam RT for early-stage breast cancer does not increase mortality risks
Date:9/24/2013

Atlanta, September 24, 2013Early-stage breast cancer patients who receive external beam therapy (XRT) are not at higher risk for serious long-term side effects in the chest area, including increase in deaths from cardiac disease and secondary malignancies, according to research presented today at the American Society for Radiation Oncology's (ASTRO's) 55th Annual Meeting.

The study utilized patient information from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) database. It evaluated women identified as having primary Stage T1aN0 breast cancer (tumor of 5mm or less that has not spread to the lymph nodes), who received surgery, with or without post-operative radiation therapy, between 1990 and 1997. The analysis was done to determine if XRT was associated with increased mortality due to breast cancer, secondary cancer in the chest area or cardiac conditions for these patients; only patients with breast cancer (BC) identified as the first malignancy were included. The women had a median age of 55-59 and were divided into two groups: 2,397 who received XRT after surgery, and 2,988 who did not receive XRT after surgery.

Cause of death (COD) codes were used to identify cardiac mortality, breast cancer mortality, and deaths from secondary chest cancers in order to assess overall survival (OS), breast cancer survival (BCS), second-tumor specific survival and cardiac-cause specific survival (CCS), and then compared between the XRT and non-XRT groups. The incidence of mortality was compared between the XRT and non-XRT groups utilizing the Chi-Square test; and, the relative risk (RR) and associated 95 percent confidence interval (CI) were calculated. Kaplan-Meier survival analysis and log-rank test were performed to assess OS, BCS, second-tumor specific survival and CCS.

At 10 years post-treatment, OS rates were 91.6 percent for the XRT patients and 87 percent for the non-XRT group; BCS rates were 97 percent for the XRT patients and 95.7 percent for the non-XRT group; and CCS was 96.7 percent for the XRT patients and 92.7 percent for the non-XRT group.

Analysis of the data further demonstrates that, with a median follow up of 14 years, there was no statistically significant difference in deaths from subsequent non-breast cancers in the chest area, the majority of which were lung cancers. The number of deaths from cardiac causes was not significantly higher for those patients treated with XRT for left-sided breast cancer, compared to those with right-sided breast cancer among the patient sample and time period reviewed. More women from the non-XRT group died from all causes, including cardiac causes, suggesting that those patients had worse general health conditions than the women who received radiation therapy.

"Breast conserving therapy, consisting of lumpectomy and XRT, has been an excellent approach to early breast cancer treatment, offering equivalent disease control and better cosmetic results compared to mastectomy as demonstrated by multiple randomized controlled trials in the past," said Jason Ye, MD, the study's presenting author and a second-year resident in radiation oncology at Weill Cornell Medical College in New York City. "Our study's results suggest that serious long-term side effects of radiation therapy, such as increase in deaths from cardiac disease and secondary malignancies, are rare. Radiation therapy is an integral part of early stage breast cancer treatment for those who choose to have a lumpectomy instead of a mastectomy, with its benefits likely far outweighing the potential risks in majority of the cases. The field of radiation oncology is rapidly changing, with new technology constantly being introduced that may reduce these risks further. Continued long term follow up and additional studies are needed to monitor for potential long term side effects."


'/>"/>

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

Related medicine news :

1. AED.com Supports Automated External Defibrillator (AED) Legislation in Schools in US and UK
2. North America Leads Automated External Defibrillator Market (AED), Says New Research Report at ReportsnReports.com
3. Automated External Defibrillator Market to Reach $930 Million by 2017 - New Report by MarketsandMarkets
4. AED.com Now Offers Automated External Defibrillator (AED) Sports Packages
5. San Jose CPR Certification Now Sells AEDs (Automated External Defibrillators) and Teaches CPR/AED Certification Training Classes in San Jose, CA
6. Joan Bowman, VP External Affair, to Speak at Mid-Continental States Association of Food and Drug Officials (MCAFDO)
7. Gammapod developed at University of Maryland School of Medicine targets early-stage breast cancer
8. NIH-developed candidate dengue vaccine shows promise in early-stage trial
9. Radiation treatment after surgery improves survival for elderly women with early-stage breast cancer
10. Many options, good outcomes, for early-stage follicular lymphoma
11. Study: Majority of older, early-stage breast cancer patients benefit from radiation after lumpectomy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... ... POUGHKEEPSIE, N. Y. – Peer-reviewed guidelines from the International Lyme and Associated ... Disease Control ( CDC ) and Infectious Diseases Society of America (IDSA) dismiss any ... into a single volume a compelling argument that the disease does exist in his ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley ... to announce a new informational post on robotic hair transplantation. San Francisco residents ... hair transplant and Follicular Unit Transplantation (FUT) can sound similar. Either treatment can ...
(Date:2/26/2017)... ... February 25, 2017 , ... The February 13, 2017, assassination of ... concern over nerve agents and the deadly use of chemical weapons. Many questions exist ... how even small doses can be lethal. , Jay Jagannathan, M.D., of Michigan-based Jagannathan ...
(Date:2/26/2017)... CA (PRWEB) , ... February 26, 2017 , ... NuevaCare, ... cities as diverse as Millbrae, Belmont, and Palo Alto, is proud to announce an ... Many Bay Area consumers look for home care close to home, and by having ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... in staffing, scheduling, and reporting for healthcare organizations. This comprehensive and customizable ... entire staffing process. StaffBridge technology improves staffing efficiency, maximizes resource allocation, collects ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 24, 2017 Research and Markets has announced ... Trends - Industry Forecast to 2025" report to their offering. ... The Global ... around 23.8% over the next decade to reach approximately $330.5 billion ... and forecasts for all the given segments on global as well ...
(Date:2/24/2017)... -- Physician General Dr. Rachel Levine and ... Smith commended South Central EMS today for their ... a life-saving overdose reversal drug. The recognition event also ... overdose survivor who was saved due to the administration ... part of fighting the opioid epidemic is making sure ...
(Date:2/24/2017)... YORK , Feb. 23, 2017 Report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... and forecasts are provided for the period 2015 through 2022. ... Market data and analytics are derived from primary and secondary ...
Breaking Medicine Technology: