Navigation Links
Extending treatment after liver transplant may benefit patients with hepatitis C recurrence
Date:10/31/2009

DETROIT Extending hepatitis C treatment for liver transplant patients beyond current practice results in high rates of clearance of the hepatitis C virus from the blood, as well as a low rate of relapse, according to a Henry Ford Hospital study.

"We found that patients who achieved a sustained virological response were more likely to have had extended treatment," says Kimberly Brown, M.D., Division head of Gastroenterology at Henry Ford Hospital and senior author of the study.

"In addition, prolonging treatment for 52 weeks after patients were virus negative, resulted in a relapse rate of only 8 percent." This is in contrast to typical relapse rates of 30-35 percent in non transplant patients treated with standard therapy.

Study results will be presented during an oral presentation Oct. 31 at the American Association for the Study of Liver Diseases' Annual Meeting in Boston.

The study looked at 241 consecutive liver transplant patients from 1999-2006. Patients were offered treatment if they tested positive hepatitis C, had recurrent hepatitis C with at least Stage I fibrosis on biopsy, and stable immunosuppression for a minimum of three months. Patients received either non-pegylated interferon tiw or pegylated interferon weekly in combination with ribavirin.

Of the study patients with hepatitis C, 66 were eligible for treatment, and 22 achieved sustained virological response. Only two patients (8 percent) relapsed.

After week 24 of treatment, 35 percent of patients who achieved a sustained virologic response became virus negative.

"These results call into question previous studies which suggested 'stop rules' at weeks 12 and 24 when there is no response to inferferon and ribravirin," says Dr. Brown. "Our results suggest that even if patients are positive at week 24, there is still a 35 percent chance that they can achieve sustained viral clearance. We think this may be beneficial to extend treatment beyond the standard 48 weeks total."

According to the U.S. Department of Health & Human Services, more than 16,000 liver transplants were performed last year and there are currently almost 18,000 Americans on the liver transplant list.


'/>"/>

Contact: Maria Seyrig
mseyrig1@hfhs.org
313-874-4039
Henry Ford Health System
Source:Eurekalert  

Related medicine news :

1. Study puts brakes on extending indications for cardiac resynchronization therapy
2. Haas TCM Acquires MC Technologies Extending Its Healthcare Environmental Information Management Systems and Chemical Management Services Offering
3. CDC Panel Urges Extending Flu Vaccine Coverage for Kids
4. The HealthCentral Network Acquires MedTrackAlert, Extending its Ability to Reach Highly Engaged Online Health Consumers
5. Fast Radios Introduces RoIP: Extending Two-Way Radio Range Thousands of Miles
6. Poll Shows Liberals Opposed to Extending Taxpayer Funded Healthcare to Illegal Immigrants
7. Sunrise Enters into 13th Amendment to Credit Agreement Extending Maturity Date to December 2, 2010
8. New treatment effective in counteracting cocaine-induced symptoms
9. New treatment boosts muscle function in myasthenia gravis
10. Broad-based group of physicians calls for improvement in stroke treatment
11. Cranberry Could Juice Up Ovarian Cancer Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Extending treatment after liver transplant may benefit patients with hepatitis C recurrence
(Date:1/17/2017)... , ... January 17, 2017 , ... ... Center joined the Peoples Health network on Dec. 1, 2016. Peoples Health, ... “JenCare Senior Medical Center is an exciting addition to our provider network, and ...
(Date:1/17/2017)... ... January 17, 2017 , ... Wettstein Agencies, a Denver ... business professionals throughout central Colorado, is joining local nonprofit Aurora Warms The Night ... The Night organization is committed to breaking the cycle of homelessness and poverty ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... families from two offices in Tyler, has announced the latest beneficiary of their ... Wish Network, a nonprofit organization dedicated to fulfilling the dreams of terminally ill ...
(Date:1/16/2017)... Boston, MA (PRWEB) , ... January 17, 2017 ... ... winter season, Au Bon Pain, an internationally recognized leader in the fast-casual category, ... new items such as the Good Egg Breakfast Sandwich, Turkey Mash-Up Sandwich, Cranberry ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... With the ... opened on January 8 for use by sports teams and the general public. Built ... volleyball courts that can also be converted into basketball or pickleball courts. The space ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... -- Interpace Diagnostics Group, Inc., (NASDAQ: IDXG ), ... and pathology services for evaluating risks of cancer, announced ... 13, 2017 from the NASDAQ Listing Qualifications notifying the ... of the NASDAQ Stock Market to maintain a minimum ... The letter noted that for the last 10 days ...
(Date:1/17/2017)... Research and Markets has announced the addition ... their offering. ... The global laparotomy sponges market to grow at a CAGR of ... Sponges Market 2016-2020, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:1/17/2017)... , Jan. 17, 2017 Tempus, ... cancer care, and University Hospitals Seidman Cancer Center ... by making genomic data, advanced molecular analysis and ... researchers, physicians and healthcare providers. ... provide genomic and transcriptomic sequencing and analysis for ...
Breaking Medicine Technology: