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Extended outcomes from APBI show tumor control, breast cosmesis and minimal late toxicity
Date:1/29/2014

therapy, with 66.9 percent receiving hormonal therapy, 13.4 percent chemotherapy and 8.3 percent chemotherapy with hormonal therapy. Follow-up was conducted every three to four months for the first two years post-treatment, and every six months thereafter at the discretion of the patient's breast surgeon and radiation oncologist. Baseline mammograms were performed three to six months after treatment, and annually thereafter. In addition, cosmetic outcomes were documented via photography at each visit, and toxicity was assessed during the final follow-up visit.

At a median follow-up of 5.5 years post-treatment, the five-year and seven-year actuarial ipsilateral breast control were 98 percent/98 percent, the lymph nodal control were 99 percent/98 percent and the distant control were 99 percent/99 percent. The breast cancer specific survival was 100 percent at five years and 99 percent at seven years. The overall survival was 89 percent at five years and 86 percent at seven years. There were no significant differences in tumor recurrence or survival rates in the appropriateness subgroups based on ASTRO's consensus statement. Good to excellent breast cosmesis was reported in 93.4 percent of patients. Overall toxicity rates were low, and the most common toxicity was telangiectasia, small, dilated blood vessels near the surface of the skin, which was reported in 27 percent of study participants. The study correlated telangiectasia development and the maximum radiation dose to the skin. The study institution practice is to keep maximum skin dose ≤ 100 percent and at maximum ≤ 125 percent to limit the risk of telangiectasia.

"These results may encourage women to choose this convenient five-day treatment and also help radiation oncologists use techniques that can reduce skin dose further, thus further reducing the long-term effects of partial breast radiation therapy on skin changes and breast cosmesis," said Sushil Beriwal, MD, a co-author
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Contact: Brittany Ashcroft
press@astro.org
703-839-7336
American Society for Radiation Oncology
Source:Eurekalert

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