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Extended outcomes from APBI show tumor control, breast cosmesis and minimal late toxicity
Date:1/29/2014

Fairfax, Va., January 29, 2014 Long-term (five-year) outcomes of breast cancer patients receiving adjuvant accelerated partial breast irradiation (APBI) after breast-conserving surgery show excellent tumor control and breast cosmesis (cosmetic outcomes) with minimal late toxicity, according to a study published in the February 1, 2014 print edition of the International Journal of Radiation Oncology • Biology • Physics (Red Journal), the official scientific journal of the American Society for Radiation Oncology (ASTRO).

APBI delivers highly conformal radiation therapy, during a period of one to two weeks, to the site where the cancer was removed. APBI has seen a 10-fold increase in use from 2002 to 2007 and is currently the focus of several ongoing phase III trials.

The University of Pittsburgh Cancer Institute study examines the long-term outcomes, tumor control and breast cosmesis of a cohort of early-stage and ductal carcinoma in situ (DCIS) breast cancer patients who received a five-day treatment of APBI at the University of Pittsburgh from 2002 to 2007.

The study is a retrospective review of 157 patients with localized breast cancer treated with adjuvant MammoSite, single-lumen balloon-based brachytherapy after breast-conserving surgery from June 1, 2002 to December 31, 2007. For all patients, at least five years had passed since receiving brachytherapy. Patients were all age 40 or older, with 88.5 percent over age 50, and had stage T1-T2 breast cancer, with 82.4 percent in stage T1A-C, 12.2 percent with DCIS, 4.7 percent in stage T2 and 0.7 percent in stage T1mic. Patients were also categorized by demographics and tumor characteristics into suitable, cautionary and unsuitable groups based on recommendations from ASTRO's APBI Consensus Statement.

APBI was delivered to a median dose of 34 Gy in 10 fractions over a five-day period. In addition, 89 percent of patients received additional adjuvant systemic
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Contact: Brittany Ashcroft
press@astro.org
703-839-7336
American Society for Radiation Oncology
Source:Eurekalert

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