Navigation Links
Extended hepatitis C treatment after liver transplant may benefit patients
Date:5/2/2010

DETROIT Extending hepatitis C treatment for liver transplant patients beyond current standards results in high clearance rates of the hepatitis C virus from the blood, and a low relapse rate, according to a study by Henry Ford Hospital.

"We found that patients who achieved a sustained virological response were more likely to have had extended treatment after transplant," says Matthew Moeller, M.D., gastroenterology fellow at Henry Ford Hospital and lead author of the study.

"In the study, we saw a trend toward decreased mortality as sustained virological response was found to be associated with a 100 percent five-year survival rate vs. 86 percent for those without."

Although, statistically insignificant, the trend could show significance with longer follow-up and a larger sample size, explains Dr. Moeller.

Study results will be presented May 2 at the Digestive Diseases Week conference in New Orleans.

The study looked at 241 consecutive liver transplant patients from 1999-2006. Patients were offered treatment if they tested positive for hepatitis C, had recurrent hepatitis C with at least Stage I fibrosis on biopsy, and stable immunosuppression for a minimum of three months. Patients received either non-pegylated interferon tiw or pegylated interferon weekly in combination with ribavirin.

Of the study patients with hepatitis C, 66 were eligible for treatment, and 22 achieved sustained virological response. Only two patients (8 percent) relapsed. This is in contrast to typical relapse rates of 30-35 percent in non-transplant patients treated with standard therapy. Genotype 1 patients failed more than genotype 2 or 3 patients in achieving sustained virological response (27 percent vs. 70 percent).

Dr. Moeller notes that 35 percent of patients who went on to achieve sustained virological response first became virus-negative at or following week 24.

"Our results suggest that even if patients are positive at week 24, there is still a 35 percent chance that they can achieve sustained viral clearance with extended treatment," says Dr. Moeller.


'/>"/>

Contact: Maria Seyrig
mseyrig1@hfhs.org
313-874-4039
Henry Ford Health System
Source:Eurekalert

Related medicine news :

1. More smokers kick the habit with extended nicotine patch therapy, Penn research shows
2. Cymetrix to Provide Extended Business Office Services at UC San Diego Medical Center
3. Loyola's Doctor of Nursing Practice Application Deadline Extended
4. HITSP Contract With U.S. HHS Extended Through April 2010
5. Alterian Announces Extended Partnership with youDb in Brazil
6. NVHR: Administrations 2011 Budget Proposal Shortchanges Five Million Americans Afflicted with Chronic Viral Hepatitis
7. NVHR Issues Challenge to Administration, Congress: Dont Leave 5 Million Americans Afflicted with Chronic Viral Hepatitis Out in the Cold with Budget Freeze
8. New Treatment Eyed for Hepatitis C
9. Treatment for chronic hepatitis C: A phase II study
10. New Hepatitis C Treatment Shows Promise
11. NVHR Offers Congressman Hank Johnson Support & Encouragement as He Battles Chronic Hepatitis C Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... (PRWEB) , ... January 17, 2017 , ... Recently, patients ... in Southwest Michigan, joined other volunteers and organizations in support of the annual Binder ... children and families dressed up in colorful costumes of all designs coming out to ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... products, will demonstrate their groundbreaking GunSport•PRO® and EB15•LE® electronic earplugs at the NSSF ... in Las Vegas, Booth #2809. The SHOT Show is the shooting, hunting and ...
(Date:1/16/2017)... ... January 16, 2017 , ... Houston dentist, ... is currently offering complimentary consultations and financing for orthodontics for a limited time. ... irregularities and learn about their orthodontic options. Walk-in, late-evening, Saturday, and same-day appointments ...
(Date:1/16/2017)... ... 2017 , ... Specialty Technical Publishers (STP) and Specialty Technical ... (IAPC) EHS audit protocol for Singapore . Leading companies around the world ... obligations and rapidly collect, share, archive, and export audit findings in a cost ...
(Date:1/16/2017)... ... January 16, 2017 , ... Date aired: ... http://www.ageofautism.com/legal , Sharon Kleyne, America’s leading water educator, researcher and advocate welcomed ... radio program, The Sharon Kleyne Hour Power of Water, Global Climate Change and ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan 17, 2017 Research and ... Market 2016-2020" report to their offering. ... The global laparotomy sponges market to ... Global Laparotomy Sponges Market 2016-2020, has been prepared ... The report covers the market landscape and its growth prospects over ...
(Date:1/17/2017)...  ANI Pharmaceuticals, Inc. ("ANI") (Nasdaq: ... Quinn Ph.D as Vice President Corticotropin Regulatory Affairs, ... Karen Quinn is a professional with over ... Affairs, specifically with a focus on drug products ... most recently with Takeda Pharmaceuticals International as Senior ...
(Date:1/17/2017)... , Jan. 17, 2017  Bayer today announced the appointment ... Pharmaceuticals business in the Americas, comprising the United ... Latin America . In this role, Dr. ... the Board of Management of Bayer AG and President of ... highly respected leader in the pharmaceutical industry and I,m delighted ...
Breaking Medicine Technology: