Navigation Links
Expression of certain transporter proteins may predict resistance to drug therapy
Date:6/18/2010

Rome, Italy, Friday 18 June: The expression of a transporter protein called the Breast Cancer Resistance Protein (BCRP) in rheumatoid arthritis (RA) patients may indicate higher disease activity and could be a barrier to the effectiveness of disease-modifying antirheumatic drugs (DMARDs), according to the results of a study presented today at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy.

In a Turkish study, researchers analysed specimens of synovium (the soft tissue that lines the surfaces within joints) from patients with RA who had undergone knee or hip replacement surgery. The presence of BCRP was reported in 41% of samples from RA patients, compared with 0% of samples in the healthy control group. The level of BCRP staining (a technique where a stain specific to a particular protein is used) was more prominent, indicating that the protein was being expressed at higher levels in cells actively involved in the immune response (macrophages, endothelial cells and fibroblasts).

Furthermore, of the 40% of RA patients with cells that showed a presence of BCRP, some had a higher concurrent disease activity score (DAS28, an index that rates scores of 28 tender and swollen joints) despite receiving treatment for their condition, when compared with patients without BCRP. Researchers noted that this difference was not statistically significant (4.320.32 vs 3.371.16, p>0.05).

"The results of our study show that the presence of BRCP was only detected in patients with RA and that arguably it is found more prominently in patients with high disease activity," said Dr. Umut Kalyoncu, Hacettepe University Rheumatology Department, Ankara, Turkey, and lead author of the study. "The BCRP protein is a pump involved in transporting substances across the cellular membrane. What we hypothesise is that, due to the location of the cells showing highest levels of BCRP, the presence of this protein may create
'/>"/>

Contact: Rory Berrie
eularpressoffice@uk.cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

Page: 1 2

Related medicine news :

1. “You Are Very Pretty”, Says Myeexpert As It Releases A Book, Poetic Expressions, Dedicated To The Beauty of Women.
2. Spanish gene expression data promise targeting of anti-angiogenesis treatment
3. Gene expression test reduces need for invasive heart muscle biopsy
4. Personal Tragedy Reveals Untapped Artistic Expression / Family Business Memorializes Loved Ones with Compassion During Grieving
5. Mechanical forces could affect gene expression
6. Hong Kong Government Invites Expressions of Interest in Development of Private Hospitals
7. New Tests for Prostate Cancer Might Bring More Certainty
8. Certain Popular Antidepressants Linked to Cataracts in Seniors
9. Genes Link to Certain Cancers Questioned
10. Challenging the use of routine repeated chest X-rays in certain patients
11. Drug now used to treat erectile dysfuncton may enhance delivery of herceptin to certain brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... brain of a rat and a robot could revolutionise ... leading robotics researcher. , Dr Michael Milford from ... uses new computer algorithms to enable robots to navigate ... is a very Frankenstein type of project," Dr Milford ... together because we,re taking the eyes of a human ...
(Date:10/1/2014)... suggests the adage that encourages people to keep their ... it comes to exercise. When walking, staying focused on ... it appear shorter and help people walk there faster, ... technique to walking while looking around the environment naturally, ... exercise. , "People are less interested in exercise if ...
(Date:10/1/2014)... 01, 2014 Bedros Keuilian is not ... Camp fitness boot camps, he’s also considered the leading ... with sold out business summits, a line of high-demand ... to a recent Spike TV reality show to his ... is the time for personal trainers and fitness business ...
(Date:10/1/2014)... and ATLANTA (PRWEB) October 01, 2014 ... security executive networking and relationship-marketing firm, announced ... Information Security Executive® and Project of the ... top-ranking decision makers representing organizations in financial ... Projects include large-scale technology endeavors that address ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Beverly Hills ... Kathleen Mojas is celebrating 20 years of private practice ... hundreds of people to achieve greater joy and fulfillment ... list of warning signs and suggestions for anyone who ... Mojas explains: “Believe it or not, it’s not ...
Breaking Medicine News(10 mins):Health News:Robot researcher combines nature to nurture 'superhuman' navigation 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 3Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3
... , , JACKSONVILLE, Fla., ... network, today announced the expansion of its existing partnership with ... include secure real-time eligibility and benefits transactions at no charge ... relationship between Availity and WellCare for health care claims transactions, ...
... FORT LAUDERDALE, Fla., Aug. 25 OmniComm Systems, Inc. ... data capture (EDC) solutions for clinical trials, announced today ... Pleiad, Inc., a Cambridge, Massachusetts based Contract Research Organization ... eClinical services to its customers. Pleiad,s investment will provide ...
... , , LOUISVILLE, Colo., Aug. ... Plastic and Reconstructive Surgery Journal , the official journal ... been clinically proven to be a safe and effective treatment ... University demonstrated VASER Lipo to be an enhanced fat removal ...
... Serrated colorectal polyps include the subgroups hyperplastic polyps, sessile ... adenomas. Recent studies have found that serrated polyps share ... to the hypothesis that serrated polyps can be precursors ... to cancer sequence. These cancers tend to arise in ...
... , , , INDIANAPOLIS , ... its selection as one of LATINA Style magazine,s "Top Twelve Companies ... in the magazine,s 50 Report. More than 800 companies were considered ... Style magazine is an acknowledgment that our mission to improve the ...
... say , TUESDAY, Aug. 25 (HealthDay News) -- A ... tumors has been identified by German researchers. , The ... cancer and compared them with healthy breast tissue. The ... of GLI1 (glioma-associated oncogene homolog 1) protein tended to ...
Cached Medicine News:Health News:Availity Provides Real-Time Access to WellCare 2Health News:Pleiad Devices Selects OmniComm Systems as their eClinical Solutions Provider 2Health News:Pleiad Devices Selects OmniComm Systems as their eClinical Solutions Provider 3Health News:New Study Reveals VASER(R) Lipo to be the New Standard of Care for Body Contouring and Fat Transfer Procedures 2Health News:New Study Reveals VASER(R) Lipo to be the New Standard of Care for Body Contouring and Fat Transfer Procedures 3Health News:Reinterpretation of proximal colon polyps called hyperplastic in 2001 2Health News:WellPoint Named a Top Place to Work by LATINA Style Magazine 2Health News:WellPoint Named a Top Place to Work by LATINA Style Magazine 3Health News:Protein May Identify Deadlier Breast Cancer 2
(Date:10/1/2014)... and NEW YORK , October 1, 2014 ... Organization (CRO) and service provider for the medical industries, announced today ... offices in New York City . genae Americas ... is strategically centered in one of the highest concentrations ... said Philippe Kassab , President at genae Americas. "The expansion ...
(Date:10/1/2014)... , Oct. 1, 2014  Express Scripts (NASDAQ: ... available 2015 Express Scripts Medicare ® Prescription Drug ... featuring Walgreens (NYSE: WAG ) (NASDAQ: ... choice and clinical support  for their Medicare dollars. ... Medicare Value or Choice plans ...
(Date:10/1/2014)... 2014  CVS Health is thanking its 26,000 pharmacists ... changing the way health care is delivered to increase ... retail pharmacies, mail service pharmacies and specialty pharmacies nationwide.  ... name to CVS Health to reflect our broader health ... needed to shape the future of health," said ...
Breaking Medicine Technology:genae Opens Offices in New York City 2Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 2Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 3Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 4CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 2CVS Health Thanking its Pharmacists during American Pharmacists Month for Helping People on Their Path to Better Health 3
... Announces Positive Data in Animal Models of ... /PRNewswire-FirstCall/ -- Callisto,Pharmaceuticals, Inc. , a developer ... cancer and other major health threats, announced,today ... compound currently being developed for the treatment,of ...
... Journal of Cell Science Shows ONCONASE Uptake in,Cells ... 2007 /PRNewswire-FirstCall/ --,Alfacell Corporation today announced that European ... to enter,cells. , Published in the Journal of ... studies conducted at the University of Girona in,Spain ...
Cached Medicine Technology:Callisto Intends to Move Guanilib into Clinical Trials in,Ulcerative Colitis 2Callisto Intends to Move Guanilib into Clinical Trials in,Ulcerative Colitis 3Callisto Intends to Move Guanilib into Clinical Trials in,Ulcerative Colitis 4Researchers Identify Intracellular Pathway of Alfacell's Onconase 2Researchers Identify Intracellular Pathway of Alfacell's Onconase 3
The Volk 60D provides high magnification - making it ideal for detailed disc and macular viewing. Its 31mm diameter facilitates easy handling within the orbital area. Available with SupraCoat (argon...
Provides exceptional resolution and fundus scanning capability. Excellent for small pupil diagnosis and treatment....
The 15D provides high magnification along with an optimized working distance from the cornea. With its 4.11x magnification it is also well suited for disc and macular observation....
... Automated Urine Microscopy Analyzer (iQ200) uses ... software to classify urine particles into ... The iQ200 eliminates most technologist time ... images by automating specimen preparation, image ...
Medicine Products: