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Exposure to low doses of BPA linked to increased risk of prostate cancer in human stem cells
Date:6/17/2013

lopmental exposure to environmentally relevant levels of BPA increases human prostate cancer risk."

Investigators were able to observe the effects of BPA on living prostate tissue by isolating prostate stem cells from young men, then combining these cells with undifferentiated cells called mesenchyme, which, for this study, derived from rat tissue. They then grafted this combined tissue to the kidneys of mice where the tissue developed into human prostate tissue. To simulate human BPA exposure, the investigators fed BPA at levels found in humans to the study mice for the first two weeks of the prostate-tissue formation.

One month after the tissue graft, when the prostate tissue had matured, the investigators administered estrogen and testosterone at elevated levels to the study mice to promote prostate disease.

The National Institutes of Health's National Institute of Environmental Health Sciences funded the study.


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Contact: Jenni Glenn Gingery
jgingery@endocrine.org
301-941-0240
The Endocrine Society
Source:Eurekalert

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