Navigation Links
Exposure to low doses of BPA linked to increased risk of prostate cancer in human stem cells
Date:6/17/2013

SAN FRANCISCO- Exposing developing tissue to low levels of the plastic bisphenol A, commonly known as BPA, is linked to a greater incidence of prostate cancer in tissue grown from human prostate stem cells, a new study finds. The results were presented Monday, June 17, at The Endocrine Society's 95th Annual Meeting in San Francisco.

BPA is a synthetic estrogen that is used to add flexibility to many common products, including food cans and containers, compact discs, eyeglasses, and even baby bottles. It is universally prevalent, and tests indicate that almost everyone has measurable levels of the chemical in their bodies.

The chemical has received a great deal of media attention in recent years because of its potential to increase the risk of disease. The concern about BPA in the human body is that it is an endocrine-disrupting chemical, which means that it alters the body's hormonal balance by replicating the activity of a naturally occurring hormone. In this case, BPA replicates the activity of estrogen. Of greatest concern are BPA's effects on developing fetuses and infants because endocrine-disrupting chemicals are thought to predispose developing cells to later disease.

In this study, investigators used human prostate stem cells from organ donors to grow prostate tissue in a mouse model. They found that early BPA exposure significantly increased the risk of both prostate cancer and a precancerous condition known as prostate epithelial neoplasia, or PIN. The incidence rates for PIN and prostate cancer were:

  • 12 percent of non-BPA exposed tissue
  • 33-45 percent of tissue exposed to BPA

"These results suggest that stem cells are direct BPA targets which may explain the long-lasting effects of this chemical throughout the body," said study lead author Gail S. Prins, Ph.D., professor of physiology and urology at the University of Illinois at Chicago. "They provide the first direct in vivo evidence that developmental exposure to environmentally relevant levels of BPA increases human prostate cancer risk."

Investigators were able to observe the effects of BPA on living prostate tissue by isolating prostate stem cells from young men, then combining these cells with undifferentiated cells called mesenchyme, which, for this study, derived from rat tissue. They then grafted this combined tissue to the kidneys of mice where the tissue developed into human prostate tissue. To simulate human BPA exposure, the investigators fed BPA at levels found in humans to the study mice for the first two weeks of the prostate-tissue formation.

One month after the tissue graft, when the prostate tissue had matured, the investigators administered estrogen and testosterone at elevated levels to the study mice to promote prostate disease.

The National Institutes of Health's National Institute of Environmental Health Sciences funded the study.


'/>"/>

Contact: Jenni Glenn Gingery
jgingery@endocrine.org
301-941-0240
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Cutting-Edge 3-D Technology at Midtown Dentistry Reduces Patient X-Ray Exposure
2. TCE exposure linked to increased risk of some cancers
3. Pesticide Exposure May Raise Parkinsons Risk, Study Suggests
4. Hidden Beach, the Only Luxurious All-inclusive Nudist Resort in the Mexican Caribbean, to Host Social Exposure's Naked Painting Party, Announces Go Classy Tours
5. Exposure to Secondhand Smoke May Lead to Worsening of Pediatric Kidney Disease; Pediatric Nephrology Publishes Dayton Children’s, Johns Hopkins Joint Study
6. Early-life traffic-related air pollution exposure linked to hyperactivity
7. Dr. Jeffrey Carlson Successfully Performs Procedure Using SpineFrontier’s Less Exposure Surgery Technology: FacetFuse
8. Agent Orange exposure linked to life-threatening prostate cancer
9. Among Hispanics, Risky Sun Exposure Varies by Language Spoken: Study
10. Lung Cancer Asbestos Victims Center Now Urges Victims Of Lung Cancer Or Mesothelioma To Contact Them If They Had Exposure To Asbestos At Work-Significant Compensation
11. Lung Cancer Asbestos Victims Center Now Urges Victims of Mesothelioma Or Any Type Of Lung Cancer To Call Them If Had Exposure To Asbestos At Work-Compensation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... A local study examining asthma ... 40 percent of participating fifth-grade students already have or are at risk for ... Research in the Division of Pulmonary, Allergy and Critical Care Medicine at ...
(Date:5/5/2016)... ... 2016 , ... Sun Health registered nurse Brittany Eads and ... Care Transitions program at the 9th Annual Orthopedic and Spine Summit held ... Post-Acute Environment Through Effective Transitions of Care.” , Major changes are taking place ...
(Date:5/5/2016)... ... (PRWEB) May 05, 2016 , ... Talent Tech Labs (TTL) ... the eve of National Nurses Week (May 6-12). Currently, HireNurses is a ... their enrollment into the Talent Tech Lab Virtual Incubation program, they will dramatically expand ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... The Lung Institute will celebrate ... attending a seminar at most clinic locations throughout the month of May. To date, the ... , “The rapid growth that we’ve seen is a testament to the success of this ...
(Date:5/5/2016)... ... May 05, 2016 , ... With May flowers, summer is just around the corner. Summer means ... respite from school and the ability to play all day and night. Parents often lament ... watch the little tykes themselves. Summer also means trips to the beach, backyard cookouts, fireworks ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 2016 Yissum Research Development ... today that it had signed an exclusive world-wide licensing ... of novel protein degradation and immunomodulatory drugs for cancer ... drug candidates representing first-in-class therapy for hematologic and solid ... The novel technology was developed by ...
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Acute Myeloid Leukemia Market ... to their offering.       (Logo: ... Myeloid Leukemia Market and Competitive Landscape Highlights ... Leukemia pipeline products, Acute Myeloid Leukemia epidemiology, ...
(Date:5/3/2016)... , May 4, 2016 Research ... "Global Cancer Stem Cell Therapy Market Outlook 2020" ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,Recombinant technology has improved significantly ... expected to be developed in coming years. Many cancer ... Cancer stem cell therapies are also expected to be ...
Breaking Medicine Technology: