Navigation Links
Exposure to inflammatory bowel disease drugs could increase leukemia risk
Date:8/6/2014

Bethesda, MD (August 6, 2014) Immunosuppressive drugs called thiopurines have been found to increase the risk of myeloid disorders, such as acute myeloid leukemia and myelodysplastic syndrome, a rare bone marrow disorder, seven-fold among inflammatory bowel disease (IBD) patients. These data were reported in a new study published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association (AGA). Thiopurines are an established treatment for IBD patients, used to reduce inflammation and provide symptom relief.

"In order to make appropriate, informed decisions about thiopurines, patients and providers need to be well-educated about the risks and benefits of this treatment," said study author Laurent Peyrin-Biroulet, MD, PhD, department of hepato-gastroenterology, University Hospital of Nancy-Brabois in France. "According to our research, the risk of myeloid disorders was not increased among the overall IBD population, compared with the general population, however it was increased amongst those taking thiopurines. We hope these findings encourage other researchers to investigate more about the drug and its potentially harmful effects."

Researchers conducted a prospective observational study to determine the trends of IBD patients exposed to thiopurines. The researchers studied 19,486 patients enrolled in the Cancers Et Surrisque Associ aux Maladies inflammatoires intestinales En France study from May 2004 through June 2005. After three years of follow up, five patients were diagnosed with incident myeloid disorders. Four of these patients had been previously exposed to thiopurines. Patients who were not receiving thiopurines during the study and those who never received these drugs did not have an increased risk of myeloid disorders.

While these findings provide strong evidence of the connection between thiopurines and myeloid disorders in IBD patients, the absolute risk to an individual patient is only 1 in 10,000. The link between IBD patients receiving thiopurines and myeloid disorders remains complex. Physicians need to balance this risk against the known benefits of thiopurines in the management of IBD.


'/>"/>
Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Exposure to dim light at night may make breast cancers resistant to tamoxifen
2. Infant toenails reveal in utero exposure to low-level arsenic, Dartmouth study finds
3. Study: Motivational interviewing helps reduce home secondhand smoke exposure
4. BPA exposure during fetal development raises risk of precancerous prostate lesions
5. Beaumont research finds advanced CT scanners reduce patient radiation exposure
6. Exposure to TV violence related to irregular attention and brain structure
7. Does dad matter? New study looks at his environmental exposure in reproductive success
8. Early exposure to certain bacteria may protect toddlers from wheezing
9. Study links evening blue light exposure to increased hunger
10. Study of third hand nicotine from e-cigarette exposure wins NIH Addiction Science Award
11. Water pipe smoking causes significant exposure to nicotine and cancer-causing agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2017)... ... June 25, 2017 , ... An increase in wetter weather in ... plants, and along with that; a humdinger of an allergy season. A relief from ... an increase in misery-causing grass and weed pollen. , “Our patients have been ...
(Date:6/25/2017)... ... 25, 2017 , ... With a heatwave currently bearing down on Northern California pushing temperatures to ... Being swimsuit ready is easy with laser hair removal. , The process of summer ... burdensome routine when all you want to do is get out, dive in and cool ...
(Date:6/24/2017)... Tampa, Fla. (PRWEB) , ... June 24, 2017 ... ... Fla., is now offering genetic testing for medications in select Florida and Texas ... of pharmacogenomics. , This new application of genetic testing recognizes the role ...
(Date:6/24/2017)... Ronkonkoma, New York (PRWEB) , ... June 24, ... ... now joined the Dental365 family. Located at 217 Portion Road in Lake Ronkonkoma, ... also open evenings and weekends so that visits to the dentist fit into ...
(Date:6/24/2017)... ... 24, 2017 , ... Doorknobs are for convenience, deadbolts are for security. , ... dog or having an alarm system installed. But unless there is a working deadbolt ... owner of TX Premier Locksmith in Killeen, TX says: “In the majority of home ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... BRUSSELS and INDIANAPOLIS , ... people are living with diabetes. In a further effort ... benefit people affected by this condition, the International Diabetes ... LLY ) have come together for the second ... Environments and Systems programme (BRIDGES 2), reaffirming their commitment ...
(Date:6/7/2017)... , June 7, 2017  Novavax, Inc., (Nasdaq: ... two Phase 2 trials of its RSV F protein recombinant ... bearing age have been published in the journal ... been shared in prior scientific conferences). The Company previously announced ... 2014. Novavax is developing the RSV F Vaccine with the ...
(Date:6/2/2017)... , June 2, 2017  NxStage Medical, Inc. (Nasdaq: ... care, today announced new findings demonstrating positive biochemical outcomes ... System One™. The data will be presented at ... Madrid, Spain . ... Improve Home Dialysis Network in Europe ...
Breaking Medicine Technology: