Navigation Links
Exposure to dim light at night may make breast cancers resistant to tamoxifen
Date:7/24/2014

ly the natural melatonin cycle, which may, in itself, paradoxically impair breast cancer responsiveness to tamoxifen."

For the study, Hill and colleagues analyzed rats living in either normal light/dark conditions, with 12 hours of light followed by 12 hours of complete darkness, or conditions in which there were 12 hours of normal light followed by 12 hours of dim light. Melatonin levels in the blood of rats living in normal light/dark conditions rose during the dark period before decreasing again during the light period. In rats living in the dim night light conditions, melatonin levels remained low throughout the light/dark cycle.

Tumor growth in rats living in the dim night light conditions was 2.6-fold faster compared with tumor growth in rats living in normal light/dark conditions. In addition, tumors in rats living in dim night light conditions were completely resistant to tamoxifen, whereas tumors in rats living in normal light/dark conditions regressed significantly. If rats living in dim night light conditions were given a nighttime melatonin supplement, their tumors regressed.

"These data suggest that, in the not-too distant-future, it may be possible to combine melatonin and tamoxifen," said Hill. "However, before this is done we would need to identify the optimal times of day to give the two because if the timing between the two is off, the advantage of giving them in combination may be lost. This brings up another important point: Our levels of melatonin are not determined by sleep, as many people think. It is actually the darkness that is important. During the night, if you sleep in a brightly lit room, your melatonin levels may be inhibited; however, if you are in the dark but cannot sleep, your melatonin levels will rise normally."


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
2. Genetic variants, tobacco exposure and lung cancer risk
3. Leaded Gas Exposure Linked to Later Violence: Study
4. Majority of states fail to address youth exposure to alcohol marketing
5. Prenatal exposure to pollution especially dangerous for children with asthma
6. Novel biomarkers reveal evidence of radiation exposure
7. Education May Protect Brain From Exposure to Solvents
8. Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection
9. New research showing how real-life exposure to violence disrupts a childs sleep habits
10. BPA exposure effects may last for generations
11. How MyTownInsurance.com Helps Insurance Carriers Manage their Loss Exposure through On-Line Marketing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... Salt Lake City, UT (PRWEB) February 27, 2015 ... “ Best and Worst Commuter Cities in Florida ... analyzed traffic data from the 2013 U.S. Census ... exceeded 10,000 at the time of the survey. ... the city level, including methods of commuting and ...
(Date:2/27/2015)... 27, 2015 On time and under ... Mercy Hospital Joplin. Inside and out, the nearly 900,000-square-foot ... community to replace the tornado-ravaged St. John’s Regional Medical ... building is opening just 46 months after the tornado ... would normally anticipate to plan, design and construct a ...
(Date:2/27/2015)... 27, 2015 The Radiology Business ... its next class of Fellows — one of the ... business management. , Since 2009, the RBMA Fellowship ... by RBMA members to the Association and the profession. ... because each Fellow candidate must meet a very high ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Leading massage ... and wellness to Americans nationwide. Each month they take a ... health and wellness, and healthy living. In the month of ... National Sleep Awareness Week starts by bringing awareness to ... This year Sleep Awareness Week will start on March 2nd, ...
(Date:2/27/2015)... According to a Feb. 12, 2015 ... used to treat cancer by killing cancer stem cells, has ... Administration (FDA) for use in the treatment of mesothelioma.* According ... FDA to encourage the development of drugs for the treatment ... the FDA’s decision,” said Melinda Helbock, Founder of The Law ...
Breaking Medicine News(10 mins):Health News:40 Best and Worst Commuter Cities in Florida Announced by Obrella 2Health News:New Hospital Built to Stand Against Nature 2Health News:New Hospital Built to Stand Against Nature 3Health News:New Hospital Built to Stand Against Nature 4Health News:RBMA Issues Call for Fellowship Applicants 2Health News:Emassagechair Wants Shoppers to Think About the Benefits of Massage During National Sleep Awareness Week 2Health News:Emassagechair Wants Shoppers to Think About the Benefits of Massage During National Sleep Awareness Week 3Health News:New Drug Receives FDA Approval as Orphan Drug for the Treatment of Mesothelioma 2Health News:New Drug Receives FDA Approval as Orphan Drug for the Treatment of Mesothelioma 3
... , FRIDAY, Jan. 27 (HealthDay News) -- Folks ... suggests. Researchers say it may be easier for ... communicate through video or in person because they don,t feel ... Yu, assistant business professor at Wichita State University School of ...
... News) -- ,Researchers who identified a new genetic signature ... lead to targeted treatment for the deadly cancer. ... screened samples from 287 patients with gastrointestinal tumors and ... IDH2) may account for nearly one-fourth of bile duct ...
... California occupational safety program requiring all businesses to eliminate ... but only if it is adequately enforced, according to ... first-ever evaluation of the California Injury and Illness Prevention ... but only at businesses that had been cited for ...
... News) -- Caffeine changes women,s estrogen levels and has different ... More than 250 women, ages 18 to 44, took part in ... milligrams of caffeine a day, about the equivalent of one cup ... by the ovaries. Asian women who consumed an average of ...
... -- The typical victim of gang-related homicide is a young ... murders aren,t drug-related, according to a new U.S. government report. ... 2003-2008 data from large cities in 17 states. They say ... Los Angeles; Oklahoma City; Long Beach, Calif.; Oakland, Calif.; and ...
... find employment in the U.S. hospitality industry face employers ... preconceived notions that they cannot do the job and ... without disabilities, according to new research from the University ... Andrew Houtenville, associate professor of economics and research director ...
Cached Medicine News:Health News:People May Lie More When Texting: Study 2Health News:Researchers Spot Potential Bile Duct Cancer Drug Targets 2Health News:Workplace safety program can reduce injuries if aggressively enforced, study finds 2Health News:Workplace safety program can reduce injuries if aggressively enforced, study finds 3Health News:Caffeine May Alter Women's Estrogen Levels 2Health News:Gang Murders Taking Toll on Young Males, CDC Says 2Health News:UNH research: US hospitality industry often reluctant to hire people with disabilities 2
(Date:2/26/2015)... , Feb. 26, 2015  Mail-service and ... consumers, employers and government health plans $23.3 ... released by the Pharmaceutical Care Management Association (PCMA). ... drugs offers one of the easiest ways to ... Mark Merritt . "Policymakers should resist efforts ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015  BD Life ... Company) (NYSE: BDX ), a leading ... innovative company focused on enabling high-resolution biology, today ... unique solutions for highly multiplexed cell isolation and ... are promoting BD,s powerful BD FACS™ single-cell sorting ...
(Date:2/26/2015)... 2015  Lyric Pharmaceuticals Inc. today announced the initial ... million. The financing, co-led by RiverVest Venture Partners, Sante ... Venture Partners. Lyric is a clinical-stage ... , M.D., M.B.A., President & Chief Executive Officer and ... In 2014, Lyric closed a seed financing round of ...
Breaking Medicine Technology:PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Texas Employers, Consumers and Public Programs by $23.3 Billion 2BD and Cellular Research Announce Co-marketing Efforts for Single-Cell Sequencing 2BD and Cellular Research Announce Co-marketing Efforts for Single-Cell Sequencing 3
... to respond to agency during first quarterKENILWORTH, N.J., Jan. ... today announced that the U.S. Food and Drug Administration ... (asenapine) sublingual tablets in the acute treatment of schizophrenia ... or mixed episodes associated with bipolar I disorder in ...
... Clinical Trial for the Treatment of Pediatric Eosinophilic Esophagitis ... Cephalon, Inc . (Nasdaq: CEPH ) ... today announced that the companies have signed an agreement ... capital stock of Ception. Under the terms of ...
Cached Medicine Technology:U.S. FDA Issues Complete Response Letter for SAPHRIS(TM) (ASENAPINE) in the Acute Treatment of Both Schizophrenia and Bipolar I Disorder 2Cephalon Signs Option Agreement to Acquire Ception Therapeutics 2Cephalon Signs Option Agreement to Acquire Ception Therapeutics 3Cephalon Signs Option Agreement to Acquire Ception Therapeutics 4
... integration of Trabecular Metal material ... design results in a fusion of ... meets surgeon demands for initial and ... wide variety of shell and liner ...
Trident Hemispherical Acetabular Shells are a true hemispherical shape designed to achieve press-fit fixation by under-reaming the acetabulum....
The Bofor acetabular revision cup addresses cases of severe acetabular destruction....
Implex cemented hip stem....
Medicine Products: