Navigation Links
Exposure to chemicals in environment associated with onset of early menopause
Date:3/23/2011

Chevy Chase, MD A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) found that higher levels of perfluorocarbons (PFCs) in the body are associated with increased odds of having experienced menopause in women between 42 and 64 years old. Women in this age group with high levels of PFCs also had significantly lower concentrations of estrogen when compared to women who had low levels of PFCs.

PFCs are man-made chemicals used in a variety of household products including food containers, clothing, furniture, carpets and paints. Their broad use has resulted in widespread dissemination in water, air, soil, plant life, animals and humans, eve in remote parts of the world. A probability sample of U.S. adults, found measurable concentrations of PFCs in 98 percent of the participants tested.

"The current study is the largest ever to be done on the endocrine-disrupting effects of perfluorocarbons in human women," said Sarah Knox, PhD, of the West Virginia University School of Medicine in Morgantown and lead author of the study. "Our data shows that after controlling for age, women of perimenopausal and menopausal age in this large population are more likely to have experienced menopause if they have higher serum concentrations of PFCs than their counterparts with lower levels."

In this study of 25,957 women aged 18 to 65 years, researchers ascertained menopausal status of participants and then measured their serum concentration levels of PFCs and estradiol. They found that there was an association between PFC exposure, decreased estradiol and early menopause in women over age 42. There was also an inverse association between PFC levels and estradiol in women of child bearing age but this association was not statistically significant.

"There is no doubt that there is an association between exposure to PFCs and onset of menopause, but the causality is unclear," said Knox. "Part of the explanation could be that women in these age groups have higher PFC levels because they are no longer losing PFCs with menstrual blood anymore, but, it is still clinically disturbing because it would imply that increased PFC exposure is the natural result of menopause."

PFCs are known to have multiple adverse health outcomes including increased cardiovascular risk and impairment of the immune system.

"Our findings suggest that PFCs are associated with endocrine disruption in women and that further research on mechanisms is warranted," said Knox.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Exposure to organochloride pesticides affects semen quality
2. Tanning bed exposure can be deadly when complicated by medication reactions
3. Many Dialysis Patients at Risk for High Radiation Exposure
4. Innovative virtual reality exposure therapy shows promise for returning troops
5. Lead Exposure May Raise Blood Pressure in Pregnancy
6. New study to use smart phones to track air pollution exposure
7. Prenatal Exposure to Pesticides May Harm Kids Development
8. Risk of cancer increases with exposure to low-dose radiation
9. Secondhand television exposure linked to eating disorders
10. Exposure to death and dying can have a positive impact
11. Nicotine exposure in pregnant rats puts offspring at risk for learning disabilities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... SC&H Group, a leading audit, tax, ... in its IT Advisory Services practice . Rossi is the third technology consulting ... for strategic IT guidance grows, and the practice continues to expand.     , Bringing more ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... offices in Tyler, has announced the latest beneficiary of their thriving community involvement ... nonprofit organization dedicated to fulfilling the dreams of terminally ill patients. Donations to ...
(Date:1/17/2017)... ... January 17, 2017 , ... Twelve (12) years ago the ... Education program forged a relationship built upon the foundation of sports safety. ... of both student members and certified members of the Athletic Trainers’ Society of ...
(Date:1/16/2017)... ... January 16, 2017 , ... Gym Source, America’s leading retailer of premium ... East Hanover, New Jersey. , “We are elated to be opening this new showroom,” ... is designed to give clients a seamless and motivating shopping experience.” , Every fitness ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... office , Antoine Dental Center, is currently offering complimentary consultations and financing for ... their teeth examined for bite irregularities and learn about their orthodontic options. Walk-in, ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... 2017  Maureen L. Mulvihill, President and CEO ... 6 senior sales leaders to support the nationwide ... leaders were formerly part of the top producers ... recognized for their performance, they have a proven ... relationships with key customer constituencies. "I have ...
(Date:1/17/2017)... , Jan. 17, 2017  ANI Pharmaceuticals, Inc. ... the appointment of Karen Quinn Ph.D as Vice ... Karen Quinn is ... experience in Global Regulatory Affairs, specifically with a ... ingredients.  Dr. Quinn worked most recently with Takeda ...
(Date:1/17/2017)... RAPIDS, Mich. , Jan. 17, 2017 /PRNewswire/ ... Richard M. Erwin as Vice President, ... Pharmaceuticals, where he was Executive Director, Clinical Project Management. ... over 25 years of experience in global clinical ... string of successful growth-stage clinical operation build-outs and ...
Breaking Medicine Technology: