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Exposure to Secondhand Smoke May Lead to Worsening of Pediatric Kidney Disease; Pediatric Nephrology Publishes Dayton Children’s, Johns Hopkins Joint Study
Date:5/21/2013

Dayton, OH (PRWEB) May 21, 2013

In adults with chronic kidney disease (CKD), cigarette smoking is associated with an increased risk for CKD progression and transplant failure. Now, a first-of-its-kind study by researchers at Dayton Children’s Hospital and Johns Hopkins University has found a possible similar effect in children with kidney disease who are exposed to secondhand smoke.

The study of 366 children aged 1 to 16 years is the first study of the effect of secondhand smoke exposure in CKD, according to lead researcher Abiodun Omoloja M.D., Associate Professor of Pediatrics at Wright State University's Boonshoft School of Medicine, and attending pediatric nephrologist at Dayton Children’s.

“Within the study population of children with CKD, the researchers found that 22 percent had been exposed to secondhand smoke. They also discovered that exposure to secondhand smoke was associated with higher presence of proteinuria (an abnormal amount of protein in the urine), which is a strong risk factor for CKD progression,” Dr. Omoloja says.

The researchers were able to identify children's exposure to secondhand smoke by testing for the presence of cotinine, a metabolite of nicotine that shows up in the urine.

The study was published recently in Pediatric Nephrology, the Journal of the International Pediatric Association. The research was funded by the Dayton Children's Foundation.

Researchers were “very surprised” at the relatively high percentage of children exposed to secondhand smoke, says researcher Derek Ng, ScM, of the Johns Hopkins Bloomberg School of Public Health Department of Epidemiology. “Twenty-tw
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