Navigation Links
Exposure to BPA may cause permanent fertility defects, Yale researchers find
Date:3/8/2010

Researchers at Yale School of Medicine have discovered that exposure during pregnancy to Bisphenol A (BPA), a common component of plastics, causes permanent abnormalities in the uterus of offspring, including alteration in their DNA. The findings were reported in the March issue of Journal of the Federation of American Societies for Experimental Biology (FASEB J.).

Led by Hugh S. Taylor, M.D., professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale, the study is the first to show that BPA exposure permanently affects sensitivity to estrogen.

Taylor and his team used two groups of mice, one exposed to BPA as a fetus during pregnancy and another exposed to a placebo. They examined gene expression and the amount of DNA modification in the uterus. They found that the mice exposed to BPA as a fetus had an exaggerated response to estrogens as adults, long after the exposure to BPA. The genes were permanently programmed to respond excessively to estrogen.

"The DNA in the uterus was modified by loss of methyl groups so that it responded abnormally in adulthood," said Taylor. "The gene expression was permanently epigenetically altered and the uterus became hyper-responsive to estrogens."

Taylor said that exposure to BPA as a fetus is carried throughout adulthood. "What our mothers were exposed to in pregnancy may influence the rest of our lives. We need to better identify the effect of environmental contaminants on not just crude measures such as birth defects, but also their effect in causing more subtle developmental errors."


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Page: 1

Related medicine news :

1. Occupational sunlight exposure and kidney cancer risk in men
2. Years of Exposure to Traffic Pollution Raises Blood Pressure
3. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
4. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
5. New cardiac CT technology drastically reduces patient radiation exposure
6. MSU researcher links potentially deadly infection, frequent cow exposure
7. Imaging manufacturers: Plan to reduce unnecessary radiation exposure and medical errors
8. Exposure to 9/11 Fumes Tied to Chronic Headaches
9. Jion Beijing Great Wall International Travel Agency Immediate Exposure to China Expo 2010
10. Exposure to secondhand smoke among children in England has declined since 1996
11. Lead Exposure May Contribute to ADHD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... 31, 2016 , ... Twenty years ago it was revolutionary: enabling the people ... the voices they hear. But this approach has proven transformative, both for people who ... gained credibility and now is used around the world, but it still lags in ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... ... commercial molecular diagnostics device that enables unprecedented portability and convenience. , The Cube ... four inches cubed in size, the Cube fits easily into any space, whether ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... WaterField Designs, ... digital-minded professionals, announces the waxed-canvas and leather Duo Dopp Kit , the ideal ... canvas or ballistic nylon, the Duo is smartly designed for Dad’s grooming ...
(Date:5/31/2016)... ... May 31, 2016 , ... Phynd Technologies, Inc. announced recently the signing of ... TX and Shore Medical Center – Somers Point, NJ. The new clients range in ... demonstrating the breadth of Phynd’s solution and its interoperability. , Houston Methodist is a ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... firm and statement solutions provider, for the tenth consecutive year as a ... issue of Advertising Age, and SourceLink ranked eighteenth in the “U.S. CRM/Direct Marketing ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... Mich. , May 31, 2016  Diplomat Pharmacy, Inc. ... pharmacy, has announced that Phil Hagerman , Chairman & ... the upcoming William Blair 36 th Annual Growth Stock ... Mr. Hagerman and Mr. Whelan are scheduled to present at ... Central Time. A live audio-only webcast of the presentation and ...
(Date:5/31/2016)... , May 31, 2016 Mundipharma ... initiation of a first-in-human clinical trial of its investigational ... - S101 is currently being developed for the treatment ... is designed to evaluate the safety and tolerability of ... several sites across the United States ...
(Date:5/31/2016)... The global biomaterials market is driven by the ... from chronic diseases. According to research report, "Global Biomaterials Market ... Forecasts (2016-2021) - (By Value; By Material Type - Polymer, ... By Region-North America, Europe , APAC, ROW; ... Italy , Japan , ...
Breaking Medicine Technology: