Navigation Links
Exposure to BPA in developing prostate increases risk of later cancer
Date:6/17/2013

Early exposure to BPA (bisphenol A) an additive commonly found in plastic water bottles and soup can liners causes an increased cancer risk in an animal model of human prostate cancer, according to University of Illinois at Chicago researcher Gail Prins. Prins presented her findings at the ENDO 2013 meeting in San Francisco June 17.

"This is the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day environment, increases the risk for prostate cancer in human prostate tissue," said Prins, professor of physiology and director of the andrology laboratory in urology at the UIC College of Medicine.

The increased risk can be traced to prostate stem and progenitor cells which become "sensitized" to estrogen early in development through exposure to BPA -- which mimics estrogen in the body. Environmental exposure to compounds like BPA that mimic hormones has become common, said Prins. Prostate stem cells, which are very long-lived, pass on the increased estrogen sensitivity to the prostate tissues they produce throughout life. Because prostate cancer is fueled in part by naturally rising estrogen levels in aging men, the prostate tissue's increased sensitivity to estrogen makes the development of cancer much more likely, according to Prins.

"Studies of expectant mothers in the U.S. showed that more than 95 percent of them had BPA in their urine, which means they recently ingested these compounds, " says Prins, whose work led to banning the sale of baby bottles and cups containing BPA in Chicago in 2009. Previous studies by Prins and colleagues using rats showed that exposure to elevated estrogen or BPA during embryonic development increased the rate of prostate cancer later in life. To determine if there was a link in humans, Prins developed a new animal model using human prostate stem cells implanted into mouse "hosts."

Prins took human prostate stem cells from deceased young adult male organ donors and implanted the cells into mice, where they formed human prostate tissue. To mimic exposure to BPA during early prostate development, Prins fed the mice BPA for the first two weeks after the transplant, at doses in line with those seen in pregnant American women. The tissue was then allowed to mature for a month into a human prostate-like tissue.

Next, Prins exposed the mice to elevated estrogen levels for two to four months, to mimic the normal rise in estrogen seen in aging men. Signs of cancer developed in the human prostate tissue in a third of the mice fed BPA, as compared to only 12 percent in mice that had not been fed BPA. If the stem cells were exposed to BPA before implantation and again during development, 45 percent showed signs of cancer.

"We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility for diseases including cancer," Prins says.


'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
2. Genetic variants, tobacco exposure and lung cancer risk
3. Leaded Gas Exposure Linked to Later Violence: Study
4. Majority of states fail to address youth exposure to alcohol marketing
5. Prenatal exposure to pollution especially dangerous for children with asthma
6. Novel biomarkers reveal evidence of radiation exposure
7. Education May Protect Brain From Exposure to Solvents
8. Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection
9. New research showing how real-life exposure to violence disrupts a childs sleep habits
10. BPA exposure effects may last for generations
11. How MyTownInsurance.com Helps Insurance Carriers Manage their Loss Exposure through On-Line Marketing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... ... ... Maury Regional Health has announced a large-scale adoption of AccuVein vein visualization ... Regional Medical Center is making vein visualization part of their standard of care. , ... importantly, helps our staff members locate a vein that will provide good access to ...
(Date:8/16/2017)... ... August 16, 2017 , ... A global leader in the treatment ... clinics in all 29 Indian states—bringing the country one step closer to eliminating clubfoot ... the nonprofit organization is on track to enroll 10,000 children in the clubfoot treatment ...
(Date:8/16/2017)... ... , ... Fusion Flix Inc., a Telly Award Winning, Non Profit Corporation has ... viewers in a partnership with the Amazon Video Direct Streaming Distribution Platform. , Their ... Ray disc in 2018. Proceeds will be going to further health research. , ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... TopConsumerReviews.com recently ... Lab Testing . , The healthcare industry in the United States has undergone ... are the days of needing to have a doctor’s order to get a blood ...
(Date:8/16/2017)... , ... August 16, 2017 , ... First Choice ... States, named Dr. Douglas J. Harrison, as the new Medical Director of its Sienna ... new facility Medical Director of our Sienna Plantation location,” said Dr. Michael (Derek) Caraway, ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that its ... Inc., has recently opened a New York City Office in ... of its unique Topical Wound Oxygen (TWO 2 ) homecare therapy. ... Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS accreditation ... ...
(Date:8/8/2017)... Israel, Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: BLRX), ... today reports its financial results for the second quarter ... during the second quarter 2017 and to date: ... clinical development programs for the Company,s lead project, BL-8040: ... pivotal study with BL-8040 as novel stem cell mobilization ...
(Date:8/7/2017)... Mich. , Aug. 7, 2017 Diplomat Pharmacy, ... of Joel Saban as president, effective Aug. 7, ... Urick has decided to pursue other interests and will ... "During his tenure, Paul has served us in multiple leadership ... Specialty Pharmacy in Jun. 2015 and has provided decisive, strategic ...
Breaking Medicine Technology: