Navigation Links
Exposure to 3 classes of common chemicals may affect female development
Date:4/5/2010

Researchers at Mount Sinai School of Medicine have found that exposure to three common chemical classesphenols, phthalates and phytoestrogensin young girls may disrupt the timing of pubertal development, and put girls at risk for health complications later in life. The study, the first to examine the effects of these chemicals on pubertal development, is currently published online in the journal Environmental Health Perspectives.

"Research has shown that early pubertal development in girls can have adverse social and medical effects, including cancer and diabetes later in life," said Dr. Mary Wolff, Professor of Preventive Medicine and Oncological Sciences at Mount Sinai School of Medicine. "Our research shows a connection between chemicals that girls are exposed to on a daily basis and either delayed or early development. While more research is needed, these data are an important first step in continuing to evaluate the impact of these common environmental agents in putting girls at risk."

Phenols, phthalates and phytoestrogens are among chemicals known as endocrine disruptors, which interfere with the body's endocrine, or hormone, system. They are found in a wide range of consumer products, such as nail polishes, where they increase durability, and in cosmetics, perfumes, lotions, and shampoos, where they carry fragrance. Some are used to increase the flexibility and durability of plastics such as PVC, or are included as coatings on medications or nutritional supplements to make them timed-release.

Dr. Wolff, co-principal investigator Susan Teitelbaum, PhD, Associate Professor, Preventive Medicine, and their team from Mount Sinai's departments of Pediatrics and Microbiology recruited girls from the neighborhood of East Harlem, a unique minority population considered high risk. Working with Cincinnati Children's Hospital and Kaiser Permanente Northern California, they analyzed the impact of exposure to environmental agents in a study that included 1,151 girls from New York, greater Cincinnati and northern California.

The girls were between 6- and 8-years-old at enrollment and between 7 and 9 at analysis. Researchers collected urine samples from the study participants and analyzed them for phenols, phthalates, and phytoestrogens, including 19 separate urine biomarkers.

The data showed that the three classes of chemical compounds were widely detectable in the study population, and that high exposure to certain chemicals was associated with early breast development. The strongest links were seen with phthalates and phytoestrogens, which were also among the highest exposures. One phenol, two phytoestrogens, and a subset of phthalates (those found in building products and plastic tubing) were associated with later puberty. However, the phthalates found in personal products such as lotion and shampoo, especially those with fragrance, were related to earlier breast and pubic hair development.

"We believe that there are certain periods of vulnerability in the development of the mammary gland, and exposure to these chemicals may influence breast cancer risk in adulthood," Dr. Wolff continued. "Dietary habits may also have an impact. Further study is needed to determine how strong the link is."

Consistent with previous studies, researchers also found that body-mass index (BMI) played a role in the onset of puberty. About a third of the girls were considered overweight, which is also an indicator of early breast development. As a result, some of the chemical associations differed in more or less obese girls. Researchers continue to study the impact of diet on pubertal development and eventual breast cancer risk.

"Exposure to these chemicals is extremely common," Dr. Wolff continued. "As such, while the association between chemicals and pubertal development seems small, the impact on the overall population is significant."


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Santa Monica Jury Rejects Claims of Catastrophic Brain Injury From Exposure to Mold; Plaintiff Faces Motions for Attorney Fees and Costs
2. Meth Exposure May Be Worse for Fetus Than Alcohol
3. Exposure to BPA may cause permanent fertility defects, Yale researchers find
4. Occupational sunlight exposure and kidney cancer risk in men
5. Years of Exposure to Traffic Pollution Raises Blood Pressure
6. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
7. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
8. New cardiac CT technology drastically reduces patient radiation exposure
9. MSU researcher links potentially deadly infection, frequent cow exposure
10. Imaging manufacturers: Plan to reduce unnecessary radiation exposure and medical errors
11. Exposure to 9/11 Fumes Tied to Chronic Headaches
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... Steve Helwig & Associates Insurance & Financial, serving ... program, has teamed up with Citizens Opposed to Domestic Abuse in support of its ... support all those victimized by the fear of violence in their own homes, donations ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... enrichment program serving the greater Venice, FL area, has initiated a fundraiser for ... a car accident just four days after Christmas. To support this beautiful child ...
(Date:2/8/2016)... ... February 08, 2016 , ... T.E.N., ... that nominations will be accepted February 8, 2016 through May 8, 2016 ... include the Information Security Executive® of the Year, which recognizes executives who ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... frequently. While a significant number of women and men with eating disorders report ... itself, that best predicts the development of an eating disorder. , At ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Discover the ... visit over 1,400 booths and 700 companies. Attendees also get to see the ... Colorado Garden & Home Show , at the Colorado Convention Center - 700 ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... -- Vestagen Technical Textiles, Inc., a medical technology company ... other demanding applications, today announced it has named ... Dale Pfost , PhD, who was serving as interim ... Vestagen,s Board of Directors. ® , the ... that combines fluid repellent, antimicrobial and breathability properties. VESTEX ...
(Date:2/8/2016)... Feb. 8, 2016  Unilife Corporation ("Unilife" or "Company") (NASDAQ: ... injectable drug delivery systems, today announced that it will release ... December 31, 2015 after market close on February 9, 2016. ... call to discuss these financial results.    About ... --> About Unilife Corporation ...
(Date:2/8/2016)...  Astellas Pharma Inc. President and Chief Executive Officer ... Robinson as president, Americas Operations, for Astellas US LLC, ... South America , effective April 1, 2016.  Robinson ... organization in the United States -- ... Yoshida , who is retiring in June 2016.  ...
Breaking Medicine Technology: