Navigation Links
Exposure to 3 classes of common chemicals may affect female development
Date:4/5/2010

Researchers at Mount Sinai School of Medicine have found that exposure to three common chemical classesphenols, phthalates and phytoestrogensin young girls may disrupt the timing of pubertal development, and put girls at risk for health complications later in life. The study, the first to examine the effects of these chemicals on pubertal development, is currently published online in the journal Environmental Health Perspectives.

"Research has shown that early pubertal development in girls can have adverse social and medical effects, including cancer and diabetes later in life," said Dr. Mary Wolff, Professor of Preventive Medicine and Oncological Sciences at Mount Sinai School of Medicine. "Our research shows a connection between chemicals that girls are exposed to on a daily basis and either delayed or early development. While more research is needed, these data are an important first step in continuing to evaluate the impact of these common environmental agents in putting girls at risk."

Phenols, phthalates and phytoestrogens are among chemicals known as endocrine disruptors, which interfere with the body's endocrine, or hormone, system. They are found in a wide range of consumer products, such as nail polishes, where they increase durability, and in cosmetics, perfumes, lotions, and shampoos, where they carry fragrance. Some are used to increase the flexibility and durability of plastics such as PVC, or are included as coatings on medications or nutritional supplements to make them timed-release.

Dr. Wolff, co-principal investigator Susan Teitelbaum, PhD, Associate Professor, Preventive Medicine, and their team from Mount Sinai's departments of Pediatrics and Microbiology recruited girls from the neighborhood of East Harlem, a unique minority population considered high risk. Working with Cincinnati Children's Hospital and Kaiser Permanente Northern California, they analyzed the impact of exposure to environmental agents in a study that included 1,151 girls from New York, greater Cincinnati and northern California.

The girls were between 6- and 8-years-old at enrollment and between 7 and 9 at analysis. Researchers collected urine samples from the study participants and analyzed them for phenols, phthalates, and phytoestrogens, including 19 separate urine biomarkers.

The data showed that the three classes of chemical compounds were widely detectable in the study population, and that high exposure to certain chemicals was associated with early breast development. The strongest links were seen with phthalates and phytoestrogens, which were also among the highest exposures. One phenol, two phytoestrogens, and a subset of phthalates (those found in building products and plastic tubing) were associated with later puberty. However, the phthalates found in personal products such as lotion and shampoo, especially those with fragrance, were related to earlier breast and pubic hair development.

"We believe that there are certain periods of vulnerability in the development of the mammary gland, and exposure to these chemicals may influence breast cancer risk in adulthood," Dr. Wolff continued. "Dietary habits may also have an impact. Further study is needed to determine how strong the link is."

Consistent with previous studies, researchers also found that body-mass index (BMI) played a role in the onset of puberty. About a third of the girls were considered overweight, which is also an indicator of early breast development. As a result, some of the chemical associations differed in more or less obese girls. Researchers continue to study the impact of diet on pubertal development and eventual breast cancer risk.

"Exposure to these chemicals is extremely common," Dr. Wolff continued. "As such, while the association between chemicals and pubertal development seems small, the impact on the overall population is significant."


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Santa Monica Jury Rejects Claims of Catastrophic Brain Injury From Exposure to Mold; Plaintiff Faces Motions for Attorney Fees and Costs
2. Meth Exposure May Be Worse for Fetus Than Alcohol
3. Exposure to BPA may cause permanent fertility defects, Yale researchers find
4. Occupational sunlight exposure and kidney cancer risk in men
5. Years of Exposure to Traffic Pollution Raises Blood Pressure
6. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
7. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
8. New cardiac CT technology drastically reduces patient radiation exposure
9. MSU researcher links potentially deadly infection, frequent cow exposure
10. Imaging manufacturers: Plan to reduce unnecessary radiation exposure and medical errors
11. Exposure to 9/11 Fumes Tied to Chronic Headaches
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
Breaking Medicine Technology: