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Exploring the 'Davids and Goliaths' of therapeutic molecules
Date:4/8/2010

drug, Gleevec . "Leveraging on our technological know-how and the industry experience of Siena Biotech, we expect our partnership to spark new breakthroughs for cancer research. We especially appreciate the power of collaboration in the dynamic arena of cancer drug discovery."

Large molecule to treat bone diseases

SIgN and Siena Biotech are jointly developing a novel monoclonal antibody applicable to bone diseases such as osteoporosis. Under the agreement, Siena Biotech will characterise, develop and test the effectiveness of the monoclonal antibodies while SIgN will isolate the disease-specific human monoclonal antibody from a pool of tens of billions of polyclonal antibodies.

SIgN and Siena Biotech's antibody is another example of the world-class research being done on targeted disease therapies. The monoclonal antibody is intended to block a specific extracellular component in the molecular pathway that leads to bone loss, and thus stop the disease progression. If successful, it would reduce the risk of bone fractures and hence the associated healthcare costs for those suffering from various forms of bone frailty. Osteoporosis alone is estimated to afflict 1 in 3 women and 1 in 12 men over the age of 50 worldwide.

SIgN Chairman, Prof Philippe Kourilsky commented, "It is thanks to the excellent relationship that Singapore shares with Italy that we can collaborate in the often-neglected area of bone and tissue loss. Together with Siena Biotech, we will be using some of the world's most advanced molecular biology and antibody engineering techniques to hopefully make good progress in this area of research, and meet the dire healthcare needs of the world's ageing population."

"The strong synergies derived from shared commitment and knowledge coupled with complementary technology platforms between ETC, SIgN, and Siena Biotech will accelerate the development of novel therapies in difficult to treat diseases mak
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Contact: Yunshi Wang
wang_yunshi@a-star.edu.sg
656-826-6443
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

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