Navigation Links
Exploring the 'Davids and Goliaths' of therapeutic molecules
Date:4/8/2010

Two research units under Singapore's Agency for Science, Technology and Research (A*STAR), the Experimental Therapeutics Centre (ETC) and Singapore Immunology Network (SIgN), are collaborating with Italy's Siena Biotech S.p.A. to develop new drugs and targeted antibodies respectively, which will potentially help millions of cancer and bone loss patients across the world. This is the fifth major collaboration A*STAR has with research centres and universities in Italy .

Small molecule for cancer therapy

ETC and Siena Biotech are developing molecular inhibitors of a major signalling pathway in oncology to target difficult-to-treat forms of cancer such as gastric cancer, leukaemia and brain tumours. During this collaboration, up to six groups from ETC and some 30 scientists from Siena Biotech will be conducting tests on synthetic compounds to characterise and optimise their inhibitor function in cancer cells. A drug is expected to enter clinical trials in 2011.

Targeted forms of cancer therapy have gained significant interest since the late 1990s. They employ small molecules that inhibit mutated, overexpressed, or otherwise critical proteins characteristic of a particular cancer cell, rather than non-specifically inhibiting and killing of all rapidly dividing cells within the body. ETC and Siena Biotech's molecular inhibitors may improve the prognosis for a very significant number of cancer patients, given that gastric cancer is the fourth most common cancer in the world and the second leading cause of cancer death. Gastric cancer is also one of the most common in Singapore (fifth highest in men and seventh highest in women, according to the Singapore Cancer Registry), with over 600 cases diagnosed every year.

"ETC is committed to translating early-stage scientific discoveries into practical applications," said Prof Alex Matter, CEO of ETC and leader of the research team that discovered the first targeted anti-cancer
'/>"/>

Contact: Yunshi Wang
wang_yunshi@a-star.edu.sg
656-826-6443
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
2. Exploring the limits: Understanding the challenges facing Winter Olympic champions
3. TV Wellness Expert Jillian Michaels Teams With Harley-Davidson to Help Women Channel Their Inner Drive and Live More Fulfilling Lives
4. Massage Envy New Jersey offers $49, 1-Hour Therapeutic Massage
5. How breast cancer cells evade therapeutic attacks
6. Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
7. Cambridge Healthtech Announces Its Inaugural Encouraging Development of Therapeutics for Neglected Diseases Conference
8. Study says therapeutics for trauma patients may not be effective due to an infection
9. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
10. Castrate-Metastatic Prostate Cancer: Therapeutic Considerations for Advanced Disease
11. Elements Therapeutic Massage Announces Franchise Expansion Plan for Massachusetts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... Amber Roberson with the Robert Weaver ... Care Health, LLC and Medcase, LLC, became certified ... new professional development course on the Patient Protection ... course for agents has been approved in all ... credits from the Missouri Department of Insurance. , ...
(Date:6/19/2013)... 2013 As Januvia lawsuit ... mount in courts throughout the U.S., Bernstein Liebhard LLP ... recently held a meeting to discuss the safety of ... According to a June 12th report from Bloomberg.com, ... of Januvia and similar drugs, following a recent study ...
(Date:6/19/2013)... The Journal of Parasitology – Although ... software, it creates questions of ethics. For scientific publications, ... already published case shows, scientific publications need clear guidelines ... Journal of Parasitology features a commentary on ... article published in the Journal of the New York ...
(Date:6/19/2013)... major international study led by researchers at The University ... ibrutinib continues to show remarkable promise for the treatment ... The most recent interim findings of the 18-center Phase ... England Journal of Medicine . Previous interim findings were ... of Hematology Annual Meeting and Exposition. , ...
(Date:6/19/2013)... study published in the June 19 online edition of ... by researchers from the University of California, San Diego ... that take place when cardiac regeneration occurs in zebrafish ... that various cell lines in the heart are more ... than previously thought. , More importantly, the research reveals ...
Breaking Medicine News(10 mins):Health News:RWI Benefits, LLC Becomes PPACA Certified 2Health News:Januvia Lawsuit News: Bernstein Liebhard LLP Comments on Recent FDA Meeting to Discuss Safety of Januvia and Other Incretin Mimetics 2Health News:Januvia Lawsuit News: Bernstein Liebhard LLP Comments on Recent FDA Meeting to Discuss Safety of Januvia and Other Incretin Mimetics 3Health News:Altered Photo in Journal Article Illustrates the Need for Manipulation Guidelines 2Health News:Ibrutinib continues strong showing against mantle cell lymphoma 2Health News:Fate of the heart: Researchers track cellular events leading to cardiac regeneration 2
... , Leading breast oncologists warn of dangers of Task ... recommendation to change breast screening is a huge step backwards," ... and president of Breastcancer.org. , (Logo: ... call for mammograms to start at age 50 and to ...
... , GREEN BAY, Wis., Nov. 17 Shopko ... e-commerce business which is accessible at www.shopko.com ... and service provider for retailers, to advance the Company,s online ... the Company,s offering of Holiday items in apparel, home, accessories, ...
... Sinai School of Medicine is one of 12 sites ... to test gene therapy treatment for Alzheimer,s disease. The ... research in the U.S. The experimental treatment utilizes ... Growth Factor (NGF), a naturally occurring protein that helps ...
... care for people with multiple chronic conditions, has received ... Improvement from the American Academy of Family Physicians (AAFP), ... Medical Economics magazine. Chad Boult, MD, MPH, MBA, ... of the Roger C. Lipitz Center for Integrated Health ...
... Howard Hughes Medical Institute (HHMI) today committed four ... training program between Rice University and the University ... unique program -- founded with a 2006 HHMI ... top-10-ranked bioengineering program and M.D. Anderson,s internationally renowned ...
... ... has successfully blended custom EDM machining and lights-out automation for greater speed and accuracy ... times are critical to optimized performance. , ... Tucker, GA (PRWEB) November 17, 2009 -- A proprietary new ...
Cached Medicine News:Health News:Lives Will Be Lost With Proposed Changes to Mammography Guidelines 2Health News:Lives Will Be Lost With Proposed Changes to Mammography Guidelines 3Health News:Lives Will Be Lost With Proposed Changes to Mammography Guidelines 4Health News:Shopko Announces Launch of e-Commerce Platform 2Health News:Mount Sinai researchers to test first gene therapy For Alzheimer's patients 2Health News:'Guided Care' receives Award for Innovation in Practice Improvement 2Health News:New funds for Rice, M.D. Anderson program 2Health News:Proprietary EDM Machining Technology Boosts Speed and Accuracy for Medical Components 2
(Date:6/19/2013)... SAN JOSE, Calif. , June 19, 2013 ... (NYSE: BDX ), a leading global medical technology ... X-20 Cell Analyzer , the latest in its line of ... X-20 Cell Analyzer delivers high-performance multicolor analysis with the most ... (76.2 X 73.7 cm) and a height of 30" (76.2 ...
(Date:6/19/2013)... PLAINS, N.Y. , June 19, 2013  This ... supporting more than 300 research projects with one goal ... And in 2013, "Team In Training" (TNT), a flagship ... endurance sports training program, is marking its landmark 25 ... invest more than $875 million in research to discover ...
(Date:6/19/2013)... June 19, 2013 Today MedeAnalytics, a ... the next-generation of its Employer Group and ... plans to provide their employer groups an intuitive ... medical and prescription drug claims, network utilization, and ... http://photos.prnewswire.com/prnh/20100621/SF23660LOGO ) "Employer Group and ...
Breaking Medicine Technology:New BD Biosciences Flow Cytometry Cell Analyzer Enables Complex Multicolor Experiments in Disease Research 2Celebrating 25 Years and Counting: Leukemia and Lymphoma Society's "Team In Training" Goes the Distance and Beyond for Blood Cancer Patients 2Celebrating 25 Years and Counting: Leukemia and Lymphoma Society's "Team In Training" Goes the Distance and Beyond for Blood Cancer Patients 3Celebrating 25 Years and Counting: Leukemia and Lymphoma Society's "Team In Training" Goes the Distance and Beyond for Blood Cancer Patients 4Celebrating 25 Years and Counting: Leukemia and Lymphoma Society's "Team In Training" Goes the Distance and Beyond for Blood Cancer Patients 5MedeAnalytics Introduces Next-Generation Employer Group and Individual Business Analytics Solution 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: