Navigation Links
Exploring the 'Davids and Goliaths' of therapeutic molecules
Date:4/8/2010

Two research units under Singapore's Agency for Science, Technology and Research (A*STAR), the Experimental Therapeutics Centre (ETC) and Singapore Immunology Network (SIgN), are collaborating with Italy's Siena Biotech S.p.A. to develop new drugs and targeted antibodies respectively, which will potentially help millions of cancer and bone loss patients across the world. This is the fifth major collaboration A*STAR has with research centres and universities in Italy .

Small molecule for cancer therapy

ETC and Siena Biotech are developing molecular inhibitors of a major signalling pathway in oncology to target difficult-to-treat forms of cancer such as gastric cancer, leukaemia and brain tumours. During this collaboration, up to six groups from ETC and some 30 scientists from Siena Biotech will be conducting tests on synthetic compounds to characterise and optimise their inhibitor function in cancer cells. A drug is expected to enter clinical trials in 2011.

Targeted forms of cancer therapy have gained significant interest since the late 1990s. They employ small molecules that inhibit mutated, overexpressed, or otherwise critical proteins characteristic of a particular cancer cell, rather than non-specifically inhibiting and killing of all rapidly dividing cells within the body. ETC and Siena Biotech's molecular inhibitors may improve the prognosis for a very significant number of cancer patients, given that gastric cancer is the fourth most common cancer in the world and the second leading cause of cancer death. Gastric cancer is also one of the most common in Singapore (fifth highest in men and seventh highest in women, according to the Singapore Cancer Registry), with over 600 cases diagnosed every year.

"ETC is committed to translating early-stage scientific discoveries into practical applications," said Prof Alex Matter, CEO of ETC and leader of the research team that discovered the first targeted anti-cancer
'/>"/>

Contact: Yunshi Wang
wang_yunshi@a-star.edu.sg
656-826-6443
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
2. Exploring the limits: Understanding the challenges facing Winter Olympic champions
3. TV Wellness Expert Jillian Michaels Teams With Harley-Davidson to Help Women Channel Their Inner Drive and Live More Fulfilling Lives
4. Massage Envy New Jersey offers $49, 1-Hour Therapeutic Massage
5. How breast cancer cells evade therapeutic attacks
6. Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
7. Cambridge Healthtech Announces Its Inaugural Encouraging Development of Therapeutics for Neglected Diseases Conference
8. Study says therapeutics for trauma patients may not be effective due to an infection
9. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
10. Castrate-Metastatic Prostate Cancer: Therapeutic Considerations for Advanced Disease
11. Elements Therapeutic Massage Announces Franchise Expansion Plan for Massachusetts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... (PRWEB) October 20, 2014 Women’s health ... in Obstetrics & Gynecology of Columbus, Inc., A Division ... healthcare services to more than 100,000 patients annually. Dr. ... all ages and stages of a women’s life. She ... locations in Westerville and Dublin. , Dr. Murphy ...
(Date:10/20/2014)... My Clients Plus ( http://www.MyClientsPlus.com ) today ... new module enables easy administration and routing of follow-up ... , This application allows users such as Therapists to ... to-do item to a specific client, categorize tasks the ... reminders for follow-ups. It's designed to enable easy ...
(Date:10/20/2014)... October 20, 2014 Succeed is proud to ... companies who participated in the Every Body Walk! ... public awareness project that encourages workers to be more active ... 10,000 Program, which concluded at the end of September, was ... cities and metro areas. Participating companies gave their staff ...
(Date:10/20/2014)... It’s hard to imagine what it’s like to ... around the world, it’s a reality. And while new shoes ... forced to walk barefoot on rocky terrain or sewage-lined streets ... their friends. , Buckner International's Shoes for Orphan ... in October to encourage support for Air1 and while also ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 The ... iPage ( http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the ... excellent platforms for those who want to buy ... same time. , The IT manager of Top10BestSEOHosting.com ... the most recommended suppliers for everyone. A lot ...
Breaking Medicine News(10 mins):Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2
... running, jogging on physical health have been known for a ... Germany that running can improve the mental health status as ... // ,The study participants had to complete a minimum of ... had to take up progressively difficult tests. The researchers examined ...
... has been lifted on account of no single case of bird ... racing, falconry and other bird shows were regularly conducted in Britain.// ... which was detected in Eastern Europe the events were banned to ... of bird flu was reported the health officials are planning to ...
... of two drugs in a rare medical trail. These drugs ... ,They are anti-retroviral drugs which have been studied individually ... are unapproved for the usage in AIDS patient and hence ... usage of this new unapproved AIDS drug started nine months ...
... human cancer cells in a unique way will be ... Zealand. The clinical trial would be held at New ... on Wednesday. ,Auckland University cancer researcher Professor Bill ... is converted to a DNA damaging agent in the ...
... treatment of Ambylopia or lazy eye as it is commonly called. ... at the USC and three other Chinese universities. //,A ... compromise in the vision even when corrective glasses are used. If ... condition has been regarded to be incurable in children over 8 ...
... says that elderly white women who have had non-melanoma skin ... of their exposure to the harmful rays of the sun. ... age group of 50 to 79, who had a previous ... the skin, had a two-fold increase in the risk of ...
Cached Medicine News:Health News:Health Canada Gave Access To Unapproved Drugs To AIDS/HIV Patients. 2
(Date:10/17/2014)...  Hanger, Inc. (NYSE: HGR ) announced ... operations for the quarter ended September 30, 2014, on ... conference call to discuss these results is scheduled to ... 2014. Those wishing to participate should call 1-877-662-6095. A ... by dialing 1-855-859-2056 and referencing Conference ID # 91880739. ...
(Date:10/17/2014)... October 17, 2014 ... has announced the addition of the  "China ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... in China impacted ... in consumption concept, dietary habit, way of ...
(Date:10/17/2014)... DUBLIN , October 17, 2014 ... Research and Markets ( http://www.researchandmarkets.com/research/rxznjk/micro_market ) has ... Market Monitor : North American Automated ... their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,The ... forecast, 2008-2018 analyzes the market of ...
Breaking Medicine Technology:China Interventional Cardiovascular Device Industry Report 2014-2017 2China Interventional Cardiovascular Device Industry Report 2014-2017 3Micro Market Monitor : North American Automated External Defibrillators (AED) Market 2
... responses on hot-button HIV/AIDS ... issues, Clinton, Edwards, Obama and Kucinich support ending ... for ... the AIDS Foundation of Chicago -- three of the,nation,s leading AIDS organizations -- polled 16 ...
... Radiologists are using a new minimally,invasive procedure to ... reduces pain from calcific tendonitis of,the rotator cuff ... at the annual meeting of the Radiological Society ... successful and inexpensive therapy for tendon,calcifications," said Luca ...
Cached Medicine Technology:Leading AIDS Groups Turn Up The Heat on '08 Presidential Candidates 2Leading AIDS Groups Turn Up The Heat on '08 Presidential Candidates 3Minimally Invasive Treatment Reduces Shoulder Pain From Tendonitis 2Minimally Invasive Treatment Reduces Shoulder Pain From Tendonitis 3
... Our new oversized wheelchair scales incorporate all ... model including automatic zero, weight recall, reweigh ... displays weight in pounds and kilos., ... patients in electric and oversized wheelchairs. The ...
This high-capacity stand-on scale provides extra sensitivity and support to patients who are unsteady on their feet. Advanced technology compensates for patient movement....
... Endo-PAT2000 is a simple and easy to ... PAT signal is recorded using Itamar Medical's ... is analyzed automatically using proprietary advanced Digital ... within seconds of completing the test. The ...
... C-peptide of insulin is the C-terminal cleavage ... prohormone to the mature insulin molecule. Although ... it does undergo significant liver or extra-renal ... circulating half-life than insulin [1]. In addition, ...
Medicine Products: