Navigation Links
Explaining why so many cases of cardiac arrest strike in the morning

INDIANAPOLIS, Sept. 8, 2013 Evidence from people with heart disease strongly supports the existence of the molecular link first discovered in laboratory mice between the body's natural circadian rhythms and cardiac arrest or sudden cardiac death (SCD) the No. 1 cause of death in heart attacks, a scientist said here today.

The research, which offers the most focused explanation ever for SCD's predilection for the morning hours, was part of the 246th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society. The meeting, which features almost 7,000 reports on discoveries in science and other topics, continues through Thursday in the Indiana Convention Center and downtown hotels.

Mukesh Jain, M.D., who reported on the research, said that it pinpoints a previously unrecognized factor in the electrical storm that makes the heart's main pumping chambers suddenly begin to beat erratically in a way that stops the flow of blood to the brain and body. Termed ventricular fibrillation, the condition causes SCD, in which the victim instantly becomes unconscious and dies unless CPR or a defibrillator is available to shock the heart back into its steady beat.

"Sudden cardiac death due to this electrical instability causes an estimated 325,000 deaths annually in the United States alone," Jain explained. He is with Case Western Reserve University in Cleveland. "That includes the 3 out of 4 heart disease deaths in people aged 35-44. In all too many cases, there is no second chance. The first event is the last event. Our research points the way toward possible ways of easing that toll new drugs that could reduce that risk, for example."

One of the deepest mysteries about SCD has been its timing. Health experts have known for more than 30 years that the erratic heartbeat responsible for SCD strikes most often at certain times of the day. The peak risk hours range from 6 a.m. to 10 a.m., with a smaller peak in the late afternoon. Scientists long suspected a link between SCD and the 24-hour body clock, located in the brain. It governs 24-hour cycles of sleep and wakefulness called circadian rhythms that coordinate a range of body functions with the outside environment.

Jain's group discovered a protein called KLF15 that helps regulate the heart's electrical activity, and occurs in the body in levels that change like clockwork throughout the day. KLF15 helps form channels that allow substances to enter and exit heart cells in ways critical to maintaining a normal, steady heartbeat.

They first discovered that patients with heart failure have lower levels of KLF15. Then, they established in laboratory mice that KLF15 is the molecular link between SCD and the circadian rhythm. And mice with low levels of the protein have the same heart problems as people with SCD. "It turns out that people with low KLF15 levels are the ones that are most susceptible to these sudden death episodes that occur in the early morning hours," said Jain. "So, we think that if we could in some way boost KLF15 levels in patients with heart problems, maybe we can reduce the occurrence of these arrhythmias and SCD."

Jain's group is currently studying drugs that boost KLF15 levels. The protein also has effects on other body processes, however. "If we can find out how these compounds are boosting KLF15 levels, then maybe we can make much more targeted and specific therapies for the heart that would prevent SCD, but leave the other KLF15-related processes alone," he explained. Other groups are working on developing genetic tests to identify people who have mutations in the KLF15 gene and would likely be at higher risk of SCD, he noted.


Contact: Michael Bernstein
317-262-5907 (Indianapolis Press Center, Sept. 6-11)

Michael Woods
317-262-5907 (Indianapolis Press Center, Sept. 6-11)

American Chemical Society

Related medicine news :

1. Siragusa Vein and Vascular Publishes New Article Explaining the Differences Between Varicose Veins and Spider Veins
2. Dr. Sam Speron Agrees With New Studies Explaining The Difference In Skin Aging Between Men and Women
3. Chuback Medical Group Publishes Article Explaining the Best Things to do to Reduce Vein Disease Risk
4. Online Clock Shares New Research Explaining Why People are Afraid of the Dark
5. Explaining how extra virgin olive oil protects against Alzheimers disease
6. Scientists discover new clues explaining tendon injury
7. Explaining Stevias bitter side
8. DePuy Knee Sleeve Lawsuits Help: Resource4thePeople Expands Recall Reviews to include both Knee and Hip Cases
9. Mirena IUD Lawsuit Help: Resource4thePeople Reports Number of Consolidated Cases Increases as Litigation Advances
10. Transvaginal Mesh Lawsuits Help: Resource4thePeople Reports Key Trials Scheduled in Consolidated Federal Cases as Number of Cases Increases
11. Chronic Kidney Disease Market: 81M CKD Cases by 2022 Says a New Research Report at
Post Your Comments:
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from reveals that behind the tendency to ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, ... -based mobile pulmonary function testing company, is now able to perform ... developed by ndd Medical Technologies , Inc. ... in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL ... can get any needed testing done in the comfort of her ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: