Navigation Links
Explaining chemotherapy-associated nausea
Date:1/30/2008

PHILADELPHIA (January 29, 2008) -- A new study from the Monell Center increases understanding of the biological mechanisms responsible for the nausea and vomiting that often afflict patients undergoing chemotherapy. The findings could lead to the development of new approaches to combat these debilitating side effects.

By increasing knowledge of what causes the nausea and vomiting that accompany chemotherapy treatment, we move closer to providing patients with less traumatic and hopefully more effective drug treatment regimens, said lead author Bart De Jonghe, PhD, a Monell physiologist.

Anorexia (loss of appetite) and cachexia (a syndrome of physical wasting and weight loss) often accompany chemotherapy-induced symptoms of nausea and vomiting. These side effects can compromise the patients nutritional status and impede recovery.

The research, published online in the American Journal of Physiology, uses a rat model to identify a nerve that transmits signals of chemotherapy-associated illness from the small intestine to the brain.

To explore whether sensory nerves traveling from the intestinal system to the brain contribute to nausea and illness associated with chemotherapy, the Monell researchers examined the incidence of pica in rats that received the potent chemotherapy drug cisplatin. Cisplatin treatment, widely used for a variety of cancers, is highly associated with nausea and vomiting.

Pica is the term used to describe the eating of non-food substances, such as clay or dirt. Because rats which do not vomit eat clay when made sick by toxins, researchers measure pica behavior as an indicator of nausea and malaise in these animals.

In the Monell study, rats given cisplatin began to eat clay, decreased their food intake, and lost body weight.

The researchers found that cisplatin-associated pica was reduced by 60 percent when they cut a nerve that transmits sensory signals from the small intestine to the brain. Cutting the same nerve, known as the common hepatic branch of the vagus nerve, also lessened the reduction of food intake and loss of body weight.

These results suggest that the upper intestine is an important site for generation of the nausea and appetite loss associated with chemotherapy drugs.

The findings also help to define the neural systems involved in nausea and malaise, which can significantly impact the nutritional status of patients receiving potent drug treatments for diseases such as cancer or AIDS.

This nerve may be part of a natural detection system that we use to detect toxins in food, and it is possible that we are activating it with these strong medications, comments senior author Charles Horn, PhD, a behavioral neuroscientist at Monell.

Increased understanding of this system will enable development of specific blockers to reduce nausea and improve quality of life during chemotherapy and related therapeutic regimens.

Future studies also will evaluate whether the vagus nerve contributes to other side effects associated with chemotherapy, such as altered taste perception, fatigue, and stress.


'/>"/>

Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center
Source:Eurekalert

Related medicine news :

1. ADA Calls for Scientifically Accurate Patient Brochure Explaining Filling Choices
2. Mayo Clinic study finds FDA warning against antinausea drug droperidol unnecessary
3. Acupuncture does not reduce radiotherapy-induced nausea, but patients believe it does
4. No Link Between Anti-Nausea Drug, Heart Trouble
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... January 19, 2017 , ... With the cold weather here, many people will have ... are efficient when clearing large amounts of snow, but they can be dangerous when used ... Consumer Product Safety Commission for the proper use of snow blowers:, , ...
(Date:1/19/2017)... ... January 19, 2017 , ... Remote ... recently unveiled impressive transportable capabilities with their iMedHD2™ Portable Teleultrasound System. ... to RMT technology that delivers HD, dynamic, streaming ultrasound images and video to ...
(Date:1/19/2017)... ... January 19, 2017 , ... Dr. ... Board of Dermatology and fellowship trained Mohs and cosmetic surgeon. After extensive dermatology ... Dr. Li completed his internship in internal medicine at the Emory University and ...
(Date:1/19/2017)... ... January 19, 2017 , ... Students interested in video can get a ... The winner will earn a $1,000 scholarship and have his or her video posted ... the deadline is May 31, with the winner announced on June 9. , The ...
(Date:1/19/2017)... ... ... Allegheny Health Network (AHN) officials today announced a bold new step to ... services in the greater Pittsburgh region. Starting January 23, patients who call AHN by ... same afternoon. , AHN is the first healthcare provider in the ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... global  pacemaker market  is expected to reach USD 12.3 billion by 2025, according ... cardiac conditions coupled with the availability of medical coverage is a key driving ... devices are supporting the expansion of this vertical. ... ... Logo ...
(Date:1/19/2017)... The Global Therapy Partnering Terms and Agreements ... deals and agreements entered into by the world,s leading ... Top deals by value - Deals listed by company ... The report provides understanding and access to the partnering ... healthcare companies. The report provides an analysis of ...
(Date:1/19/2017)... , Jan. 18, 2017 The drug ... billion by 2021 from USD 1,179.20 billion in 2016, ... Increasing prevalence of chronic diseases, increasing demand for ... factors driving the growth of this market. Whereas, self-administration ... generic drugs offer significant growth opportunities for players operating ...
Breaking Medicine Technology: