Navigation Links
Experts summarize state of the science in autism disorders
Date:10/14/2009

Scientific understanding and medical treatments for autism spectrum disorders (ASDs) have advanced significantly over the past several years, but much remains to be done, say experts from the Center for Autism Research at The Children's Hospital of Philadelphia who published a scientific review of the field today.

"We summarized many new findings by autism researchers throughout the world, and give our perspective on the current state of the science in autism spectrum disorders," said lead author Susan E. Levy, M.D., a developmental pediatrician and medical director of the Regional Autism Center at Children's Hospital. "We hope our review will be a useful reference for healthcare professionals working with ASD patients and families."

The article appears in the British journal The Lancet, published online on Oct. 12. Levy co-authored the review with Robert T. Schultz, Ph.D., a neuropsychologist and director of the Center for Autism Research at Children's Hospital, and David S. Mandell, Sc.D., a psychiatric epidemiologist at the University of Pennsylvania School of Medicine.

Some recurrent themes of the review are the expanding knowledge of early brain development, and the importance of early diagnosis of ASDs, accompanied by intensive early treatment. The researchers also recognize the important role of parent involvement in early recognition of ASDs and in reinforcing their child's behavioral treatments at home. They also endorse research on methods for supporting families to reduce parental stress.

As evidenced by a long history of family and twin studies, ASDs are the neuropsychiatric disorder most affected by genetic factors. The authors review recent studies performed with the help of sophisticated gene-analyzing tools, and cite the finding earlier this year that a significant percentage of ASD patients have DNA alterations in a genetic area that affects how neurons interconnect in the brain. Combined with other studies of brain anatomy and function, the authors say, "genetic and neurobiological evidence point to a good causal model of this disordernamely, genetically mediated abnormal findings of synaptic maturation and connectivity."

Further research is needed to explain in detail how genes affect the development of brain cell interconnections, but the authors say that future investigation may suggest techniques to intervene early in life with medical treatments.

Neuroimaging tools, such as magnetoencephalography (MEG), a method of mapping the brain's magnetic field, hold the potential of identifying a biological signature of ASDs, so that clinicians might identify autism during early childhood and monitor the effectiveness of treatments.

Regarding therapy, the authors note that the most researched treatments are those based on applied behavioral analysis, which includes intensive, highly structured treatments beginning in early childhood. More recently, those highly structured programs have been combined with other behavioral programs more akin to real-life situations, with increased effectiveness.

Although existing drugs do not treat core symptoms of ASDs, the authors refer to results showing medications may be effective in relieving related symptoms such as irritability and anxiety. Many other proposed and existing treatments, both biological and non-biological, have not been adequately studied.

In sum, say the authors, "no cure for autism spectrum disorders is yet available." However, "outcomes are improved with early detection and intensive treatment." In the future, the authors conclude that advances in early detection and diagnosis will allow more individualized and effective early treatment to alter the course of early behavior and brain development.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
2. MultiVu Video Feed: PUBLIC HEALTH EXPERTS CONVENE TO DISCUSS THE TREATMENT AND PREVENTION OF RABIES
3. Health IT Event Draws Experts to the Pacific Northwest
4. Experts Sort Out Good Fats From Bad
5. Experts Offer Tips on Lung Cancer Prevention
6. March of Dimes, Experts for Moms and Babies, Launches Podcast
7. World fertility experts to meet in Montreal - IVF and IVM patients to provide first-person accounts at 14th World Congress
8. Bay IVF Experts Launch One of First East-West Fertility Programs of Its Kind
9. Experts propose cholesterol tests at 15 months of age
10. Experts Publish New Lung Disease Guidelines
11. Experts, Advocates Available to Comment on Hillary Clintons Health Care Plan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island Quality ... Management Alerts and Dashboards, an innovative new service enabling healthcare providers to proactively ... Management Alerts and Dashboards provide near real-time data about patients admitted to and/or ...
(Date:6/23/2017)... ... ... By scoring 100% for fiscal management and accountability, the Arthritis National Research ... Charity Navigator, validating ANRF's work as a top charity in America. , This achievement ... earns ANRF a spot on their “ 10 Charities Worth Watching ” list as ...
(Date:6/23/2017)... ... ... Studies show evidence that carotenoids and antioxidants derived either from the diet or from ... how often do ophthalmologists and optometrists in Sweden recommend the use of nutritional supplements, ... symptoms of AMD? A study published recently in Dove Medical Press journal, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Dr. Ran Y. ... has recently begun offering three new minimally invasive procedures to patients who want ... reducing downtime, Dr. Rubinstein is excited to bring microneedling, microneedling facials, and platelet ...
(Date:6/23/2017)... ... 2017 , ... Everybody has their own personal preference when it comes to ... some people don't like it at all. FindaTopDoc took a look at what makes ... can give readers a taste of their deepest, darkest fantasies and has the ability ...
Breaking Medicine News(10 mins):
(Date:6/19/2017)... , June 19, 2017  Researchers from DRUGSCAN ® ... they will host a live, complimentary webinar titled, "Untangling ... benchtop to the real world" on Wednesday June 28, ... This webinar will feature interviews with recreational ... into the manipulation techniques abusers use to prepare opioid ...
(Date:6/14/2017)... , June 14, 2017  ivWatch LLC, a ... effectiveness of intravenous (IV) therapy, is pleased to announce ... category of Nonsurgical Hospital Supplies and Equipment at the ... program for the medtech industry. The award was presented ... Jacob K. Javits Center in New York ...
(Date:6/13/2017)... , June 13, 2017 Zimmer Biomet Holdings, Inc. ... today announced that the U.S. Food and Drug Administration (FDA) ... 3, 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter ... manufacturing facility is a measure of the progress we have ...
Breaking Medicine Technology: