Navigation Links
Experts discuss ways to embed patient voices and values in clinical research

Rochester, MN, April 30, 2013 There is worldwide concern in the biomedical research community that enrollment in clinical trials is lagging, putting clinical research and consequent benefits to society in jeopardy. Experts explore ways to embed patient voices and values in clinical research in the current issue of Mayo Clinic Proceedings.

Clinical trials of new drugs, devices, or procedures require the active participation of human volunteers. Mark A. Yarborough, PhD, of the Bioethics Program, University of California Davis, calls for greater transparency about the social value of research in recruiting patients to participate in clinical trials, as part of the initial informed consent process.

"Not all clinical research is equal," Dr. Yarborough says, comparing research into the use of stem cells to improve the life of Huntington's disease patients with "me too" drug studies that are competing with existing and effective (and often cheaper) medicines to treat conditions such as hypertension. "Clinical research has produced a lot of good, life-improving and life-saving drugs that have really improved the lot of patients. But we need to remain mindful that some trials are more deserving of public trust than others." He proposes the incorporation of a clear declaration in informed consent forms that states whether a trial is investigating a way to potentially improve current medical care and explains why it does or does not have the potential to do so.

"We owe the public honest disclosure about why any given trial is being conducted so that they understand the extent to which a trial, if completed, could promote the common good," Dr. Yarborough explains. "The informed consent process is one way to provide this disclosure to prospective research participants."

Yarborough acknowledges that there may be critics but, he continues, "One possible good outcome is just to have discussion about transparency about the research setting. I hope a consensus will emerge from this conversation that increased transparency will help to build the public's trust."

In the same issue, investigators at the Cleveland Clinic and McMaster University report on a prospective observational trial to explore the effect of the timing of obtaining consent. They monitored the timing of seeking informed consent for a moderate- to high-risk trial of clonidine and aspirin in patients undergoing non-cardiac surgery and found that, contrary to expectations, patients did not have increased anxiety or decreased understanding if they are asked on the same day as the surgery is due to take place.

"This is the first study, to our knowledge, to specifically compare the impact of consenting on the day of surgery with consenting before that time on patient comprehension," observes lead investigator Daniel I. Sessler, MD, of the Department of Outcomes Research, Cleveland Clinic. "From a practical perspective, consenting before the day of surgery appears preferable, but proposing moderate- to high-risk research on the day of surgery itself does not compromise essential elements of the consent process."

In an accompanying Editorial, Barbara A. Koenig, PhD, of the Institute for Health & Aging, University of California, San Francisco, notes that both articles focus on just a single component of human research protection: the informed consent process. "We must reform a system that valorizes the informed consent process to the exclusion of other elements of human research participant protection," says Dr. Koenig.

"I applaud efforts to conduct empirical research interrogating standard informed consent practices and we need more well-designed studies," Koenig comments, referring to the study by Sessler and colleagues. "However, current efforts to reform the conduct of human research rest too heavily on revising the informed consent process and place too much emphasis on disclosure of risk or potential researcher conflict of interest to the human research participant, to the relative exclusion of other equally important or potentially more important components of the research approval process."

Koenig also questions whether explaining the social value of a clinical trial to research participants is the answer. "Although I share Yarborough's desire to make certain that the social utility of research is highlighted ... his disclosure-based reform assumes that individual patients, confronted by information and data, will 'just say no' to research that lacks social value, in the same way they might seek to minimize personal risk," she says.

Koenig believes that a renewed focus on promoting and enabling authentic ethical reflection as well as a new pathway for embedding patient values and voices into the practice of research is needed. "We cannot simply ask individual patients, unaided, to weigh risk levels and evaluate projects by themselves."


Contact: Rachael Zaleski
Elsevier Health Sciences

Related medicine news :

1. Experts Offer Advice After Yankee Pitchers Trampoline Injury
2. NYU Langone experts present research, clinical advances at neurosurgeons meeting
3. Red Tide Likely in New England This Season, Experts Warn
4. No Proof That Gum Disease Causes Heart Disease, Experts Say
5. Leading experts on congenital muscular dystrophy convene at University of Nevada, Reno
6. Glaucoma Need Not Steal Sight, Experts Say
7. Healthy Behaviors Extend Life After Cancer, Experts Say
8. Routine Kidney Disease Screening Not Worthwhile, Experts Say
9. Columbia University Medical Center and NY-Presbyterian experts at APA meeting
10. Aim Skin Cancer Warnings at the Young, Too, Experts Say
11. Experts call for clinical trials to test non-skeletal benefits of vitamin D
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from reveals that ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, ... M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... the most handsome men, look naturally attractive. Plastic surgery should be invisible.” He ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
Breaking Medicine Technology: