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Experts cite 'misconceptions' on brain metastases
Date:6/24/2014

June 24, 2014 "Key historical misconceptions" are hindering progress in research and treatment for patients with cancer metastases to the brain, suggests a special article in the July issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Dr. Douglas Kondziolka of NYU Langone Medical Center and coauthors identify some issues that may be standing in the way of optimal clinical management for patients with cancer that has spread to the brain from other sites.

'All Brain Metastases Are Created Equal'and Other Misconceptions

Brain metastases are an important problem in cancer treatment, but one for which there are relatively few well-designed clinical trials. That partly reflects an "often nihilistic" viewpoint, given that survival is relatively short for many patients with brain metastases.

But a few key studies provide answers to some important questions on the benefits of specific treatments. At a time of rapid progress in cancer care, Dr. Kondziolka and colleagues highlight five misconceptions that, in their view, must be overcome to advance treatment for patients with brain metastases.

The first misconception is assuming that "all histologies are created equal"that the type of cancer doesn't matter once it has spread to the brain. Historically, studies have included any and all patients with brain metastases. But that may overlook important differences between brain metastases from different types and sites of cancerfor example, lung cancer, breast cancer, or malignant melanoma.

Likewise, there's no basis for the assumption that the number of brain metastases is the so
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Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

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