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Experts call for clinical trials to test non-skeletal benefits of vitamin D
Date:5/18/2012

te the efficacy of treatment with vitamin D on skin disorders or the prevention of skin cancer.
  • The ever-expanding obesity epidemic has been associated with a rising prevalence of vitamin D deficiency, but a cause-and-effect relationship has not been established. Strong evidence does not exist to support the tenet that vitamin D supplementation reduces the risk of type 2 diabetes or the metabolic syndrome.
  • Vitamin D supplementation is likely to reduce the risk of falls, particularly in individuals who have low baseline levels (<20 ng/ml) and are supplemented with calcium as well.
  • Recent systematic reviews have found that evidence that vitamin D reduces cancer incidence are inconclusive as to causality. Observational evidence is strongest for colorectal cancer but is weak or inconsistent for breast, prostate and total cancer.
  • There is a possibility that vitamin D supplementation may lower cardiovascular disease risk, but there are limitations in applying observational data to clinical practice. An insufficiency of evidence from clinical trials does not support recommending vitamin D supplementation for lowering cardiovascular disease risk at this time.
  • Clinical trials are needed to test whether vitamin D supplementation during pregnancy will prevent type 1 diabetes in offspring.

    The article, "The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement," appears in the June 2012 issue of The Endocrine Society's Endocrine Reviews.


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  • Contact: Aaron Lohr
    alohr@endo-society.org
    240-482-1380
    The Endocrine Society
    Source:Eurekalert

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