Navigation Links
Experts call for clinical trials to test non-skeletal benefits of vitamin D
Date:5/18/2012

Chevy Chase, MDThe Endocrine Society's new scientific statement published online today represents the first comprehensive evaluation of both the basic and clinical evidence related to the non-skeletal effects of vitamin D. The statement addresses current research regarding the associations of vitamin D with immune function, hypertension, stroke, skin conditions and maternal/fetal health.

Vitamin D is a steroid hormone that regulates calcium and phosphate levels in the bloodstream and promotes healthy bone growth. Vitamin D deficiency is common throughout the world and results in abnormalities of calcium, phosphorus and bone metabolism which can lead to muscle weakness, osteomalacia, osteopenia and osteoporosis. While some observational studies have shown that benefits of vitamin D may extend beyond bone health, research findings remain inconsistent.

"The role of vitamin D supplementation in the prevention and treatment of chronic non-skeletal diseases remains to be determined," says Clifford Rosen, MD, of Tufts University School of Medicine and chair of the task force that authored the statement. "We need large randomized controlled trials and dose-response data to test the effects of vitamin D on chronic disease outcomes including autoimmunity, obesity, diabetes, hypertension and heart disease."

The scientific statement outlines the evidence that defines the effects of vitamin D on epidermal, neuromuscular, maternal/fetal and neoplastic (abnormal growth) tissues. The authors critically evaluated the literature for each organ system utilizing available evidence from observational studies and randomized trials to determine the strength of associations between vitamin D and tissue-specific outcomes.

Conclusions from the statement include:

  • Topical and oral vitamin D may be useful in treating skin disorders such as psoriasis, though large-scale randomized placebo-controlled clinical trials are needed to demonstrate the efficacy of treatment with vitamin D on skin disorders or the prevention of skin cancer.
  • The ever-expanding obesity epidemic has been associated with a rising prevalence of vitamin D deficiency, but a cause-and-effect relationship has not been established. Strong evidence does not exist to support the tenet that vitamin D supplementation reduces the risk of type 2 diabetes or the metabolic syndrome.
  • Vitamin D supplementation is likely to reduce the risk of falls, particularly in individuals who have low baseline levels (<20 ng/ml) and are supplemented with calcium as well.
  • Recent systematic reviews have found that evidence that vitamin D reduces cancer incidence are inconclusive as to causality. Observational evidence is strongest for colorectal cancer but is weak or inconsistent for breast, prostate and total cancer.
  • There is a possibility that vitamin D supplementation may lower cardiovascular disease risk, but there are limitations in applying observational data to clinical practice. An insufficiency of evidence from clinical trials does not support recommending vitamin D supplementation for lowering cardiovascular disease risk at this time.
  • Clinical trials are needed to test whether vitamin D supplementation during pregnancy will prevent type 1 diabetes in offspring.

The article, "The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement," appears in the June 2012 issue of The Endocrine Society's Endocrine Reviews.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Aim Skin Cancer Warnings at the Young, Too, Experts Say
2. Columbia University Medical Center and NY-Presbyterian experts at APA meeting
3. Routine Kidney Disease Screening Not Worthwhile, Experts Say
4. Healthy Behaviors Extend Life After Cancer, Experts Say
5. Glaucoma Need Not Steal Sight, Experts Say
6. Leading experts on congenital muscular dystrophy convene at University of Nevada, Reno
7. No Proof That Gum Disease Causes Heart Disease, Experts Say
8. Red Tide Likely in New England This Season, Experts Warn
9. NYU Langone experts present research, clinical advances at neurosurgeons meeting
10. Experts Offer Advice After Yankee Pitchers Trampoline Injury
11. Stroke experts write a doctors guide for minimizing the risk of stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology: